Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Maria Letizia Barreca"'
Autor:
Laura Salvadori, Martina Paiella, Beatrice Castiglioni, Maria Laura Belladonna, Tommaso Manenti, Catia Ercolani, Luca Cornioli, Nausicaa Clemente, Andrea Scircoli, Roccaldo Sardella, Leonardo Tensi, Andrea Astolfi, Maria Letizia Barreca, Sara Chiappalupi, Giulia Gentili, Michela Bosetti, Guglielmo Sorci, Nicoletta Filigheddu, Francesca Riuzzi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116517- (2024)
Age-associated osteosarcopenia is an unresolved syndrome characterized by the concomitant loss of bone (osteopenia) and skeletal muscle (sarcopenia) tissues increasing falls, immobility, morbidity, and mortality. Unbalanced resorption of bone in the
Externí odkaz:
https://doaj.org/article/97bc4b8e0e214e6db8299f67a2fb442e
Autor:
Deborah Palazzotti, Martina Sguilla, Giuseppe Manfroni, Violetta Cecchetti, Andrea Astolfi, Maria Letizia Barreca
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 661 (2024)
Small molecules that specifically target viral polymerases—crucial enzymes governing viral genome transcription and replication—play a pivotal role in combating viral infections. Presently, approved polymerase inhibitors cover nine human viruses,
Externí odkaz:
https://doaj.org/article/1889c35aa0c342a1ac2b9e0dce2845a4
Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 993 (2023)
AKT (also known as PKB) is a serine/threonine kinase that plays a pivotal regulatory role in the PI3K/AKT/mTOR signaling pathway. Dysregulation of AKT activity, especially its hyperactivation, is closely associated with the development of various hum
Externí odkaz:
https://doaj.org/article/da0aa8bec1bd4808ac93170950d28bf7
Autor:
Giulia Marsili, Chiara Acchioni, Anna Lisa Remoli, Donatella Amatore, Rossella Sgarbanti, Marta De Angelis, Roberto Orsatti, Marta Acchioni, Andrea Astolfi, Nunzio Iraci, Simona Puzelli, Marzia Facchini, Edvige Perrotti, Violetta Cecchetti, Stefano Sabatini, Fabiana Superti, Mariangela Agamennone, Maria Letizia Barreca, John Hiscott, Lucia Nencioni, Marco Sgarbanti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10495 (2023)
There is an urgent need to identify efficient antiviral compounds to combat existing and emerging RNA virus infections, particularly those related to seasonal and pandemic influenza outbreaks. While inhibitors of the influenza viral integral membrane
Externí odkaz:
https://doaj.org/article/d243f30a22d54fe2883c6705e50abb4f
Autor:
Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 584-597 (2020)
NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is availab
Externí odkaz:
https://doaj.org/article/5d409e0254d546e4bebeb4a36d0593e8
Autor:
Andrea Astolfi, Francesca Milano, Deborah Palazzotti, Jose Brea, Maria Chiara Pismataro, Mariangela Morlando, Oriana Tabarrini, Maria Isabel Loza, Serena Massari, Maria Paola Martelli, Maria Letizia Barreca
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2295 (2022)
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and furt
Externí odkaz:
https://doaj.org/article/2a4772fbd9da4f999fa09915db20c749
Autor:
Rolando Cannalire, Gianmarco Mangiaterra, Tommaso Felicetti, Andrea Astolfi, Nicholas Cedraro, Serena Massari, Giuseppe Manfroni, Oriana Tabarrini, Salvatore Vaiasicca, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7037 (2020)
Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage t
Externí odkaz:
https://doaj.org/article/08be49557df64b43857ae72bb0206d4f
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 15842-15861 (2015)
Mitogen-activated protein kinase p38α plays an essential role in the regulation of pro-inflammatory signaling, and selective blockade of this kinase could be efficacious in many pathological processes. Despite considerable research efforts focused o
Externí odkaz:
https://doaj.org/article/ca8446faa49645eab0e3a31c17b04111
Autor:
Deborah Palazzotti, Maicol Bissaro, Giovanni Bolcato, Andrea Astolfi, Tommaso Felicetti, Stefano Sabatini, Mattia Sturlese, Violetta Cecchetti, Maria Letizia Barreca, Stefano Moro
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4041 (2019)
The use and misuse of antibiotics has resulted in critical conditions for drug-resistant bacteria emergency, accelerating the development of antimicrobial resistance (AMR). In this context, the co-administration of an antibiotic with a compound able
Externí odkaz:
https://doaj.org/article/d7a80105812947bea0c5584c51055b5a
Publikováno v:
Pathogens, Vol 7, Iss 1, p 27 (2018)
Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain
Externí odkaz:
https://doaj.org/article/bc99739d916a4c35aef6165ebfdc33d4