Výsledky vyhledávání - "Maria Laura Polo"

Akademický článek

Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.

Autor: Maria Laura Polo, Maria Victoria Arnoni, Marina Riggio, Victoria Wargon, Claudia Lanari, Virginia Novaro

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10786 (2010)

BACKGROUND: A significant proportion of breast cancer patients face failure of endocrine therapy due to the acquisition of endocrine resistance. We have explored mechanisms involved in such disease progression by using a mouse breast cancer model tha

Externí odkaz: https://doaj.org/article/2a079b110d4940e088ff8385848c1ce0

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Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity

Autor: Derek C. Radisky, Gonzalo Ricardo Sequeira, Tomás Dalotto-Moreno, Ramiro Martin Perrotta, Maria Laura Polo, Caroline A. Lamb, Virginia Novaro, Mariana Salatino, Gabriel A. Rabinovich, Claudia Lanari, Carol A. Sartorius, Gabriela Pataccini, Ana Sahores, Silvia Vanzulli

Publikováno v: Cancer Research. 81:1375-1387

The role of active antitumor immunity in hormone receptor–positive (HR+) breast cancer has been historically underlooked. The aim of this study was to determine the contribution of the immune system to antiprogestin-induced tumor growth inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1a6a880ce3315746880cf58744cccc
https://doi.org/10.1158/0008-5472.can-20-1441

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A Poor and Delayed Anti-SARS-CoV2 IgG Response is Associated to Severe COVID-19 in Children

Autor: Graciela Mosquera, Gabriela Gregorio, Maria Laura Polo, Claudia Meregalli, Laura Alvarez, Mariela García, María Marcó del Pont, María J. Chiolo, Susana Villa Nova, Maria Luisa Rolon, Inés Sananez, Macarena Uranga, Lourdes Arruvito, Patricia Tuccillo, Nicolás A. Grisolía, Jorge Lattner, Daniela Filippo, María Revetria, Melina Salvatori, Patricia Suárez, Silvia C. Algieri, María Pía Holgado, Ana L. Alcalde, Mariela F. Pérez, Valeria Nivela, Ana Ceballosa, María Temis Agosta, Patricia Coll, H. Cairoli, Eugenia M. Takata, María J. Bruera, Vanesa Seery, Nancy Simaz, Emilia Cohen, Carola Bayle, Fernando Ferrero, Sandra Di Lalla, Mariam Sarli, Jorge Geffner, Constanza Russo, Lorena I. Gimenez, Norberto De Carli, Hernán Pérez, Augusto Varese, Silvina Raiden, Claudio Piccardo, Carolina Davenport

Publikováno v: SSRN Electronic Journal.

Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60742cd433e73c4c850be410ea55e2b3
https://doi.org/10.2139/ssrn.3857602

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A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children

Autor: María Marcó del Pont, Lorena I. Gimenez, Norberto De Carli, Maria Laura Polo, Laura Alvarez, Melina Salvatori, Jorge Geffner, Augusto Varese, Juan Martín Gómez Penedo, Silvina Raiden, Eugenia M. Takata, María Revetria, Ana L. Alcalde, María Temis Agosta, Patricia Coll, Hernán Pérez, Macarena Uranga, Nancy Simaz, Constanza Russo, Mariela García, Patricia G Suárez, Ana Ceballos, Carola Bayle, Fernando Ferrero, María J. Chiolo, Susana Villa Nova, María José Rolón, Lourdes Arruvito, Héctor Cairoli, Mariam Sarli, Sandra Di Lalla, Inés Sananez, Emilia Cohen, Graciela Mosquera, Gabriela Gregorio, Jorge Lattner, Nicolás A. Grisolía, Claudia Meregalli, María J. Bruera, María P. Holgado, Silvia C. Algieri, Mariela F. Pérez, Valeria Nivela, Vanesa Seery, Claudio Piccardo, Patricia Tuccillo, Daniela Filippo, Myriam Nuñez, Carolina Davenport

Publikováno v: EBioMedicine, Vol 72, Iss, Pp 103615-(2021)
EBioMedicine

Background Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1178dfc03ef95530bf2bcf16e98ef37
https://doi.org/10.1016/j.ebiom.2021.103615

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AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

Autor: Maria May, Maria Laura Polo, Virginia Novaro, Maria Jimena Rodriguez, Martín Carlos Abba, Maria Cecilia Perrone, Claudia Lanari, Marina Riggio

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e29afc503f49a16ed35dcf0887ff4a
http://www.nature.com/articles/srep44244

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Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratioviaAIB1 or SMRT recruitment to theCCND1andMYCpromoters

Autor: Victoria Wargon, Claudia Lanari, Sebastián Giulianelli, Britta M. Jacobsen, Gonzalo Ricardo Sequeira, Maria May, Maria Alicia Gorostiaga, Alfredo A. Molinolo, Maria Laura Polo, Paola Alejandra Rojas, Marina Riggio, Virginia Novaro

Publikováno v: International Journal of Cancer. 136:2680-2692

There is emerging interest in understanding the role of progesterone receptors (PRs) in breast cancer. The aim of this study was to investigate the proliferative effect of progestins and antiprogestins depending on the relative expression of the A (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e1f02a5af162d0acf5c5b7dbeec3272
https://doi.org/10.1002/ijc.29304

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CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients

Autor: Natalia Laufer, Pedro Cahn, Maria Laura Polo, Diego Sebastian Ojeda, Héctor Rodríguez Pérez, Jorge Fabian Quarleri, Ana de Dios Martínez, Norberto Walter Zwirner, Gabriela Julia Ana Turk

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. Samples from 11 patients were included

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ebf17ecc41c3bd6e468992ea192675
https://doi.org/10.4254/wjh.v9.i25.1073

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Abstract A70: Akt2 gain or Akt1 loss drives invasion and aggressiveness in breast cancer

Autor: Claudia Lanari, Jimena Rodriguez, Maria May, Maria Laura Polo, Virginia Novaro, Diego Lucas Kaen, Marina Riggio, Cecilia Perrone

Publikováno v: Molecular Cancer Research. 14:A70-A70

Despite the improvement in the early diagnosis and the use of modern therapies, breast cancer is the second cause of death, after lung cancer, in women around the world, and this is mainly due to metastasis development distant organs. PI3K/Akt pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f77fc4b5a117cb05eba10a3b8834b6
https://doi.org/10.1158/1557-3125.advbc15-a70

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