Výsledky vyhledávání - "Maria Laura Cremona"

Akademický článek

ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.

Autor: Kazuhisa Watanabe, Elizabeth Watson, Maria Laura Cremona, Elizabeth J Millings, Jay H Lefkowitch, Stuart G Fischer, Charles A LeDuc, Rudolph L Leibel

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67234 (2013)

Ildr2, a modifier of diabetes susceptibility in obese mice, is expressed in most organs, including islets and hypothalamus, with reduced levels in livers of diabetes-susceptible B6.DBA mice congenic for a 1.8 Mb interval of Chromosome 1. In hepatoma

Externí odkaz: https://doaj.org/article/404c84fb376d47839b7f217b0be66723

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A Framework of Critical Considerations in Clinical Exome Reanalyses by Clinical and Laboratory Standards Institute

Autor: Marco L. Leung, Jianling Ji, Samuel Baker, Jillian G. Buchan, Theru A. Sivakumaran, Bryan L. Krock, Rebecca Hutchins, Pinar Bayrak-Toydemir, John Pfeifer, Maria Laura Cremona, Birgit Funke, Avni B. Santani

Publikováno v: The Journal of Molecular Diagnostics. 24:177-188

Exome reanalysis is useful for providing molecular diagnoses for previously uninformative samples. However, challenges exist in implementing a practical solution for clinicians and laboratories. This study complements the current literature by provid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049f79a7a645a6adca486cf7618c1894
https://doi.org/10.1016/j.jmoldx.2021.11.004

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Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

Autor: Charles A. LeDuc, Maria Laura Cremona, George Stratigopoulos, Rudolph L. Leibel, Wendy K. Chung

Publikováno v: Journal of Biological Chemistry. 286:2155-2170

The first intron of FTO contains common single nucleotide polymorphisms associated with body weight and adiposity in humans. In an effort to identify the molecular basis for this association, we discovered that FTO and RPGRIP1L (a ciliary gene locate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd186a56b49f84a9ede4f16abb27475f
https://doi.org/10.1074/jbc.m110.188482

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Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

Autor: Maria Laura Cremona, Ai Yamamoto, Udo Többen, Dusica Vidovic, Yuli Xie, Nathalie Aulner, Donald W. Landry, Caty Chung, Lars Branden, Gangli Gong, Katherine M. Myers, Alison Rinderspacher, Stephan C. Schürer, Yidong Liu, Monique Andersen, Shi Xian Deng

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:1715-1717

A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67daaa3c56cc2d76ef345cc1d9ff49ad
https://doi.org/10.1016/j.bmcl.2009.01.087

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Enzymically inactive members of the trans-sialidase family from Trypanosoma cruzi display -galactose binding activity

Autor: Daniel O. Sánchez, Oscar Campetella, Maria Laura Cremona, Alberto C.C. Frasch

Publikováno v: Glycobiology. 9:581-587

trans-sialidase is a unique sialidase in that, instead of hydrolizing sialic acid, it preferentially transfers the monosaccharide to a terminal beta-galactose in glycoproteins and glycolipids. This enzyme, originally identified in Trypanosoma cruzi,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a024c334745eda5a9752aba7d30a83
https://doi.org/10.1093/glycob/9.6.581

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TNF-α Up-Regulates Protein Level and Cell Surface Expression of the Leptin Receptor by Stimulating Its Export via a PKC-Dependent Mechanism

Autor: Rudolph L. Leibel, Lixia Gan, Timothy E. McGraw, Yiying Zhang, Kaiying Guo, Maria Laura Cremona

Increasing evidence suggests that inflammation/cytokines may modulate hypothalamic responses to leptin, which is a key regulator of energy homeostasis and inflammatory/stress responses. We investigated a possible role of TNF-α, a key early mediator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c7ae673869dcee237c2f44e1676a04
https://europepmc.org/articles/PMC3512064/

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The Crystal Structure and Mode of Action of Trans-Sialidase, a Key Enzyme in Trypanosoma Cruzi Pathogenesis

Autor: Maria Fernanda Amaya, Pedro M. Alzari, Alberto C.C. Frasch, Alejandro Buschiazzo, Maria Laura Cremona

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2002, 10 (4), pp.757-768. ⟨10.1016/s1097-2765(02)00680-9⟩
Molecular Cell, 2002, 10 (4), pp.757-768. ⟨10.1016/s1097-2765(02)00680-9⟩

International audience; Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent of Chagas disease, and T. brucei, the causative agent of sl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01d4b9ca024fd329139c5ae3ae32e9b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02554093

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Identification of toxigenicVibrio choleraefrom the Argentine outbreak by PCR forctxA1 andctxA2-B

Autor: Norma Binsztein, Marta Rivas, Oscar R. Burrone, Pablo Varela, Maria Laura Cremona, Rodolfo A. Ugalde, Alberto C.C. Frasch, Patricio Herrmann

Publikováno v: FEBS Letters. 315:74-76

A polymerase chain reaction (PCR) to detect a region of the A1 cholera toxin gene was applied to the identification of 43 Vibrio cholerae strains isolated from the recent outbreak in Argentina. A good correlation was observed between the GM1-enzyme-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c2a1c1276c6d0b3f63e0cc38355592
https://doi.org/10.1016/0014-5793(93)81136-n

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Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity

Autor: Alejandro Buschiazzo, Alberto C.C. Frasch, Maria Fernanda Amaya, Gastón Paris, Maria Laura Cremona, Susana Giambiagi, Pedro M. Alzari

Publikováno v: Glycobiology
Glycobiology, Oxford University Press (OUP), 2001, 11 (4), pp.305-311. ⟨10.1093/glycob/11.4.305⟩
Glycobiology, 2001, 11 (4), pp.305-311. ⟨10.1093/glycob/11.4.305⟩

International audience; Sialidases are present on the surface of several trypanoso-matid protozoan parasites. They are highly specific for sialic acid linked in α-(2,3) to a terminal β-galactose and include the strictly hydrolytic enzymes and trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582d3935966803004d314e5f48fe1b22
https://hal-pasteur.archives-ouvertes.fr/pasteur-02554090

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