Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Maria L. de Ceballos"'
1
Akademický článek
High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner
Autor: Natalia Yanguas-Casás, Cristina Torres, Andrea Crespo-Castrillo, Sonia Diaz-Pacheco, Kiera Healy, Catherine Stanton, Julie A. Chowen, Luis M. Garcia-Segura, Maria Angeles Arevalo, John F. Cryan, Maria L. de Ceballos
Publikováno v: Neurobiology of Disease, Vol 159, Iss , Pp 105495- (2021)
Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor for Alzheimer's disease (AD). Both conditions present glial activation and inflammation and show sex differences in the
Externí odkaz: https://doaj.org/article/2c5dc5f23b354140a5fdb14f25bbac0d
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2
Akademický článek
Vascular dysfunction in a transgenic model of Alzheimer’s disease: Effects of CB1R and CB2R cannabinoid agonists.
Autor: Jorge Navarro-Dorado, Nuria Villalba, Dolores Prieto, Begoña Brera, Ana María Martín-Moreno, Teresa Tejerina, Maria L. De Ceballos
Publikováno v: Frontiers in Neuroscience, Vol 10 (2016)
There is evidence of altered vascular function, including cerebrovascular, in Alzheimer’s disease (AD) and transgenic models of the disease. Indeed vasoconstrictor responses are increased, while vasodilation is reduced in both conditions. β-Amyloi
Externí odkaz: https://doaj.org/article/68b4b1df0cc143a69f0385c5148db9ec
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3
Akademický článek
β-Amyloid Peptides Are Cytotoxic to Astrocytes in Culture: A Role for Oxidative Stress
Autor: Begoña Brera, Alba Serrano, Maria L. de Ceballos
Publikováno v: Neurobiology of Disease, Vol 7, Iss 4, Pp 395-405 (2000)
β-Amyloid is cytotoxic to neurons in culture by increasing hydrogen peroxide and altering calcium homeostasis. We have evaluated the cytotoxicty of β-amyloid peptides (βA25–35 and βA1–40) and generation of hydrogen peroxide on cortical cultur
Externí odkaz: https://doaj.org/article/8ea0d635bdc94ae3887076aed29beefb
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4
Insulin regulates neurovascular coupling through astrocytes
Autor: Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschöp, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman
Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 119:e2204527119 (2022)
Digital.CSIC. Repositorio Institucional del CSIC
instname
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IRdeficient astrocytes show disturbed mitochondrial responses to glucose. While exploring th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835057f9dc0c75bd197071238b9fc85a
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67284
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6
Piperazinomethyl Tetralines: Synthesis and Affinities for D1, D2 and 5-HT2A Receptors
Autor: Tomas G-Ferreiro, Enrique Raviña, E. Rosa, Jesus Negreira, Victor M. Moldes, Jose Macalleja, José Ángel Cid, Maria L. De Ceballos, M. E. Castro
Publikováno v: Chemical and Pharmaceutical Bulletin. 43:1234-1237
Starting from the methyl ester of β-(bromomethyl)-γ-phenylbutyric acid and its m-fluoro derivative, we have prepared 2-[4[3-(p-fluorobenzoyl)-1-propyl]piperazin-1-ylmethyl]tetraline (QF0105B) and the corresponding 7-fluoro derivative (QF0106B). The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6fd549d845ba96439bda556c91e8dac
https://doi.org/10.1248/cpb.43.1234
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7
Akademický článek
Sex Differences in Hypothalamic Changes and the Metabolic Response of TgAPP Mice to a High Fat Diet
Autor: Alejandra Freire-Regatillo, Sonia Diaz-Pacheco, Laura M. Frago, María-Ángeles Arévalo, Jesús Argente, Luis M. Garcia-Segura, María L. de Ceballos, Julie A. Chowen
Publikováno v: Frontiers in Neuroanatomy, Vol 16 (2022)
The propensity to develop neurodegenerative diseases is influenced by diverse factors including genetic background, sex, lifestyle, including dietary habits and being overweight, and age. Indeed, with aging, there is an increased incidence of obesity
Externí odkaz: https://doaj.org/article/56812f3cdf844165885607394b1cc21f
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8
In vivo effects of new inhibitors of catechol-O-methyl transferase
Autor: Rivas, E., Maria L. de Ceballos, Nieto, O., Fontenla, J. A.
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus-Elsevier
1. The effects of two new synthetic compounds showing in vitro catechol-O-methyl transferase (COMT) inhibitor properties were studied in vivo and compared with the effects of nitecapone and Ro-41-0960. 2. QO IA (3-(3-hydroxy-4-methoxy-5-nitrobenzylid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f147e4161eb7d65d24384ffc8f3213b2
http://hdl.handle.net/10261/62796
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9
Synthesis and affinities for dopamine (D2) and 5-hydroxytryptamine (5-HT2A) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives
Autor: Raviña, E., Fueyo, J., Masaguer, C. F., Negreira, J., Cid, J., Loza, I., Honrubia, A., Tristán, H., Ferreiro, T. G., Fontenla, J. A., Rosa, E., Calleja, J. M., Maria L. de Ceballos
Publikováno v: Scopus-Elsevier
Digital.CSIC. Repositorio Institucional del CSIC
instname
Starting from benzo- or thienocycloalkaneacetic acids, we have prepared a series of 1-(3-p-fluorobenzoylpropyl)-4-(1-oxo-benzo- or thienocycloalkyl-2-ethyl)piperazines 8a - e containing both semirigid and linear butyrophenones pharmacophores. The aff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6e43fef4d9f1468a5dee08afb3906731
http://hdl.handle.net/10261/62869
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