Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Maria L. Zapp"'
Autor:
Ngoc Tam Tran, Cheryl Heiner, Kristina Weber, Michael Weiand, Daniella Wilmot, Jun Xie, Dan Wang, Alexander Brown, Sangeetha Manokaran, Qin Su, Maria L. Zapp, Guangping Gao, Phillip W.L. Tai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 639-651 (2020)
The gene therapy field has been galvanized by two technologies that have revolutionized treating genetic diseases: vectors based on adeno-associated viruses (AAVs), and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas gene-editi
Externí odkaz:
https://doaj.org/article/08e2826eeb014703b9f108d668239025
Autor:
Phillip W.L. Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L. Zapp, Guangping Gao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 130-141 (2018)
Recombinant adeno-associated virus (rAAV)-based gene therapy has entered a phase of clinical translation and commercialization. Despite this progress, vector integrity following production is often overlooked. Compromised vectors may negatively impac
Externí odkaz:
https://doaj.org/article/cf16e57b757e4d1cbf85534e435f7ece
Autor:
Michael Weiand, Phillip W. L. Tai, Daniella Wilmot, Maria L. Zapp, Alexander Brown, Dan Wang, Guangping Gao, Ngoc Tam Tran, Jun Xie, Sangeetha Manokaran, Kristina Weber, Cheryl Heiner, Qin Su
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 639-651 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 639-651 (2020)
The gene therapy field has been galvanized by two technologies that have revolutionized treating genetic diseases: vectors based on adeno-associated viruses (AAVs), and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas gene-editi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e819a135385a4cc8751427878ffe42
http://europepmc.org/articles/PMC7397707
http://europepmc.org/articles/PMC7397707
Autor:
Jonathan A. Epstein, Ellen L. W. Kittler, Monique W. Bruinsma, Maria L. Zapp, Mark A. Bayfield, Samuel A. Hasson, Richard J. Maraia, Denise Rockwell, Dagmar Bacikova, Daniel Ahmad, James R. Iben
Publikováno v:
Nucleic Acids Research
We used a genetic screen based on tRNA-mediated suppression (TMS) in a Schizosaccharomyces pombe La protein (Sla1p) mutant. Suppressor pre-tRNA(Ser)UCA-C47:6U with a debilitating substitution in its variable arm fails to produce tRNA in a sla1-rrm mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b085bc44ec93b432bf33dd352497c94e
https://doi.org/10.1093/nar/gkr066
https://doi.org/10.1093/nar/gkr066
Autor:
Vasily V. Vagin, Ellen L. W. Kittler, Carla Andrea Klattenhoff, William E. Theurkauf, Nadine Schulz, Maria L. Zapp, Monika Syrzycka, Zhiping Weng, Phillip D. Zamore, Hervé Seitz, Michael D. Horwich, Barry M. Honda, Shengmei Ma, Chengjian Li, Soohyun Lee, Jia Xu, Hualin Xi
Publikováno v:
Cell. 137(3):509-521
Piwi-interacting RNAs (piRNAs) silence transposons in the germ line of animals. They are thought to derive from long primary transcripts spanning transposon-rich genomic loci, “piRNA clusters.” piRNAs are proposed to direct an auto-amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f175892067c7a19e1161b05f2395c065
Autor:
Maria L. Zapp, Zhongzhen Nie, Anne B. Theibert, Masanobu Satake, John M. Logsdon, Richard T. Premont, Dan Cassel, Elspeth A. Bruford, Hiroki Inoue, Paul A. Randazzo, Richard A. Kahn
Publikováno v:
The Journal of Cell Biology
At the FASEB summer research conference on “Arf Family GTPases”, held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89455975d1d1585c1fa00d3772a021b
https://doi.org/10.1083/jcb.200806041
https://doi.org/10.1083/jcb.200806041
Autor:
Ellen L. W. Kittler, Tingting Du, Soohyun Lee, Megha Ghildiyal, Jia Xu, Maria L. Zapp, Hervé Seitz, Phillip D. Zamore, Michael D. Horwich, Zhiping Weng, Chengjian Li
Publikováno v:
Science. 320:1077-1081
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA (dsRNA) as a defense against viral infection. We identified endogenous siRNAs (endo-siRNAs), 21 nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e8357d65de677278607aa8f71f33af
https://doi.org/10.1126/science.1157396
https://doi.org/10.1126/science.1157396
Autor:
Zhong Yu, Nuria Sánchez-Velar, Ellen L. W. Kittler, Maria L. Zapp, Irina E. Catrina, Enyeneama B. Udofia
Publikováno v:
Proceedings of the National Academy of Sciences. 102:4027-4032
An important goal of contemporary HIV type 1 (HIV-1) research is to identify cellular cofactors required for viral replication. The HIV-1 Rev protein facilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7443cb732e797b1dffcdc5bc296f1a49
https://doi.org/10.1073/pnas.0408889102
https://doi.org/10.1073/pnas.0408889102
hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region
Publikováno v:
Genes & Development. 18:23-34
Human immunodeficiency virus Rev facilitates the cytoplasmic accumulation of viral RNAs that contain a Rev binding site. A human Rev-interacting protein (hRIP) was originally identified based on its ability to interact with the Rev nuclear export sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ccf3862b04a7b9e4154d0189ed7c4f
https://doi.org/10.1101/gad.1149704
https://doi.org/10.1101/gad.1149704
Autor:
Gyongyi Szabo, Twan Do, László Romics, Maria L. Zapp, Angela Dolganiuc, Christopher Marshall, Karen Kodys, Andrea Kopasz, Pranoti Mandrekar
Publikováno v:
The Journal of Immunology. 170:5615-5624
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core and nonstructural protein 3 (NS3), but not envelope 2 proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81a0c7023dfc621141fe601dcaf665
https://doi.org/10.4049/jimmunol.170.11.5615
https://doi.org/10.4049/jimmunol.170.11.5615