Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria L. Watson"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25975 (2011)
BACKGROUND:Sustained exposure of pancreatic β cells to an increase in saturated fatty acids induces pleiotropic effects on β-cell function, including a reduction in stimulus-induced insulin secretion. The objective of this study was to investigate
Externí odkaz:
https://doaj.org/article/e5abfa5cd43344deaad03875a77a287d
Publikováno v:
World's Crisis & Second Advent Messenger (Boston, MA); May 1877, Vol. 45 Issue 2, p6-6, 1/9p
Autor:
Alexander Gray, Olivier Drouin, André Marette, Maria L. Watson, Louise Lantier, Harinder S. Hundal, Charlotte J. Green, Benoit Viollet, Sophie Turban, Fiona A. Ross, Clare Stretton, D. Grahame Hardie
Publikováno v:
The Journal of Biological Chemistry
Background: The role of AMPK and PKCs as effectors of metformin action on glucose uptake (GU) in skeletal muscle cells was investigated. Results: Genetic loss/silencing of AMPK led to only a small repression in metformin-stimulated GU. Novel/conventi
Publikováno v:
The Biochemical journal. 417(3)
Saturated fatty acids, such as palmitate, promote accumulation of ceramide, which impairs activation and signalling of PKB (protein kinase B; also known as Akt) to important end points such as glucose transport. SPT (serine palmitoyl transferase) is
Publikováno v:
The Biochemical journal. 399(3)
An increase in circulating levels of specific NEFAs (non-esterified fatty acids) has been implicated in the pathogenesis of insulin resistance and impaired glucose disposal in skeletal muscle. In particular, elevation of SFAs (saturated fatty acids),
Publikováno v:
Biochemical Journal; 2009, Vol. 417 Issue 3, p791-801, 11p
Autor:
MCPHEETERS, SAM, BAILEY, BARBARA, GARNER, SARAH, CANTWELL, JIM, STARZYK, MARTIN, KULAS, JASON, ELLIOTT, NEIL, WATSON, MARIA L., ANDERSON, KEMMER, KRAMBS, BETTY, BROWN, CARL, GREEN, PHILIP, LARDNER, GEORGE, CORBIN, PEGGY
Publikováno v:
Nation. 3/19/2007, Vol. 284 Issue 11, p2-24. 2p. 1 Illustration.