Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maria L. Varela"'
Autor:
Syed M. Faisal, Jarred E. Clewner, Brooklyn Stack, Maria L. Varela, Andrea Comba, Grace Abbud, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis showing only a 5% survival rate beyond two years. This is primarily due to its aggressiveness and intra‐tumoral heterogeneity, which limits complete surgical
Externí odkaz:
https://doaj.org/article/1538c238cfc34c618bb0253cf99982f3
Autor:
Syed M. Faisal, Andrea Comba, Maria L. Varela, Anna E. Argento, Emily Brumley, Clifford Abel, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a poor prognosis due to its universal recurrence rate. GBM cells interact with the non-cellular components in the tumor microenvironment (TME), facilitating the
Externí odkaz:
https://doaj.org/article/ab3ac9d856fb4768a00c709bfdd97349
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire E. Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Yilun Sun, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Luo, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph F. Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Clinical Cancer Research. 29:1763-1782
Purpose: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ae6e6bd650e50ff11d9a3202477c21
https://doi.org/10.1158/1078-0432.ccr-22-1896
https://doi.org/10.1158/1078-0432.ccr-22-1896
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Supplementary Figures and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bec136e20960303ccc970834308449
https://doi.org/10.1158/1078-0432.22725171.v1
https://doi.org/10.1158/1078-0432.22725171.v1
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73915f46862024d3a7fa42ac585a49a1
https://doi.org/10.1158/1078-0432.22725162
https://doi.org/10.1158/1078-0432.22725162
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Purpose:Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3c3c2ce3a6c570ef17acab87c745c3
https://doi.org/10.1158/1078-0432.c.6533038
https://doi.org/10.1158/1078-0432.c.6533038
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca71017c1c8c3c2187551450d65823d
https://doi.org/10.1158/1078-0432.22489771
https://doi.org/10.1158/1078-0432.22489771
Autor:
Yoshie Umemura, Daniel Orringer, Larry Junck, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn Hervey-Jumper, Maria L. Varela, Andrea Comba, Syed M. Faisal, Daniel Zamler, Viveka N. Yadav, Patrick Dunn, Molly E.J. West, Wajd Al-Holou, Todd Hollon, Michelle M. Kim, Daniel R. Wahl, Sandra Camelo-Piragua, Andrew P. Lieberman, Sriram Venneti, Paul McKeever, Theodore Lawrence, Ryo Kurokawa, Kait Verbal, Karen Sagher, David Altshuler, Lili Zhao, Karin Muraszko, Maria G. Castro, Pedro R. Lowenstein
BACKGROUNDHigh-grade gliomas are fatal with universally poor prognosis. Initiation of effective cancer immune responses requires functional immune cells, especially afferent antigen presenting cells, which are absent from the brain parenchyma.1, 2To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8d6bdb04ddf1db589728a6eb30d70c
https://doi.org/10.1101/2022.11.04.22281950
https://doi.org/10.1101/2022.11.04.22281950
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Lou, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. Establishment of glioma-specific methylation patterns by mIDH1 reprogramming drives oncogenic features o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce63c5287ab06fa3a71a1f15e80600d
https://doi.org/10.1101/2022.06.10.495694
https://doi.org/10.1101/2022.06.10.495694
Autor:
Syed M. Faisal, Andrea Comba, Maria L. Varela, Anna E. Argento, Emily Brumley, Molly E. West, Santiago Haase, Anzar A. Mujeeb, Clifford Abel, Marcus N. Barissi, Jarred E. Clewner, Brooklyn Stack, Grace A. Abbud, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Cancer Research. 83:5835-5835
Glioblastoma (GBM) is the most aggressive and immunosuppressive form of brain tumor, and its treatment remains a large, unmet medical need. Recently, we introduced oncostreams to refer to dynamic multicellular neuropathological structures that facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad748ad6fc8e20185c0db0401ab3cdd9
https://doi.org/10.1158/1538-7445.am2023-5835
https://doi.org/10.1158/1538-7445.am2023-5835