Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Maria L. Valencik"'
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the striated muscle-spec
Externí odkaz:
https://doaj.org/article/08d835da1b874d50a18e6696442b2236
Autor:
Matthew B. Hawn, Normand Leblanc, Michael Wiwchar, Fiona Cunningham, Ramon Jose Ayon, Iain A. Greenwood, Maria L. Valencik, Abigail S. Forrest, Joydeep Aoun, Cherie A. Singer
Publikováno v:
Am J Physiol Cell Physiol
This study explored the mechanism by which Ca2+-activated Cl−channels (CaCCs) encoded by the Tmem16a gene are regulated by calmodulin-dependent protein kinase II (CaMKII) and protein phosphatases 1 (PP1) and 2A (PP2A). Ca2+-activated Cl−currents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbcc9a1292e5a27cc1eac066aa29025
https://doi.org/10.1152/ajpcell.00059.2018
https://doi.org/10.1152/ajpcell.00059.2018
Publikováno v:
Microbial Cell, Vol 3, Iss 2, Pp 53-64 (2016)
The formation of small Aβ 42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinosit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5a4ad8f5d825ab82ab5e69b7cf0699
https://doi.org/10.15698/mic2016.02.476
https://doi.org/10.15698/mic2016.02.476
Autor:
Alison J. Davis, John Joyce, Talia C. Joyce, Abigail S. Forrest, Maria L. Valencik, Iain A. Greenwood, Linda Ye, Ramon J. Ayon, Dayue Darrel Duan, Marissa L. Huebner, Normand Leblanc, Cherie A. Singer, Michael Wiwchar, Natalie Freitas
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C1229-C1243
Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca2+ levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca2+-activated Cl− channels (ClCa), an important excitatory mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade0e43b67107c3907e6cebb950c8419
https://doi.org/10.1152/ajpcell.00044.2012
https://doi.org/10.1152/ajpcell.00044.2012
Autor:
Maria L. Valencik, Honglin Tian, Lih Chyuan Ng, Joseph R. Hume, Phillip S. Keller, Deepa Ramduny, Cherie A. Singer, Xiao-Ming Shen, Judith A. Airey
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C1079-C1090
Previous studies in mouse pulmonary arterial smooth muscle cells (PASMCs) showed that cannonical transient receptor potential channel TRPC1 and stromal interaction molecule 1 (STIM1) mediate the sustained component of capacitative Ca2+entry (CCE), bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b526cafa8b3f8d869661ad8bade5902
https://doi.org/10.1152/ajpcell.00548.2009
https://doi.org/10.1152/ajpcell.00548.2009
Autor:
Carolyn S.P. Lam, John C. Burnett, Robert D. Simari, Selma F. Mohammed, Josef Korinek, Tomohito Ohtani, Maria L. Valencik, Katarina Larsen, Margaret M. Redfield
Publikováno v:
Circulation. 122:370-378
Background— Mechanisms promoting the transition from hypertensive heart disease to heart failure with preserved ejection fraction are poorly understood. When inappropriate for salt status, mineralocorticoid (deoxycorticosterone acetate) excess caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cea037b42026ae622afa730cf214d6
https://doi.org/10.1161/circulationaha.109.915215
https://doi.org/10.1161/circulationaha.109.915215
Publikováno v:
Journal of Cellular and Molecular Medicine
Cardiovascular disease (CVD) constitutes a major public health threat worldwide, accounting for 17.3 million deaths annually. Heart disease and stroke account for the majority of healthcare costs in the developed world. While much has been accomplish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30881c04b3c9f5c05d0ae2d54d66cba
https://pubmed.ncbi.nlm.nih.gov/27061217
https://pubmed.ncbi.nlm.nih.gov/27061217
Autor:
Sheldon E. Litwin, Ping Hu, Bonnie B. Punske, Maria L. Valencik, John A. McDonald, Dongfang Zhang
Publikováno v:
Circulation Research. 99:1403-1410
Integrins mechanically link the cytoskeleton to the extracellular matrix in cardiac myocytes and are thereby involved in mechanotransduction. Integrins appear to be necessary for cardiac myocyte hypertrophy. To determine the effect of increased integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351f63624bffa97292e9be8e015c24a4
https://doi.org/10.1161/01.res.0000252291.88540.ac
https://doi.org/10.1161/01.res.0000252291.88540.ac
Autor:
Maria L. Valencik, John A. McDonald, B.W. Steadman, Bruno Taccardi, Philip R. Ershler, Alice H. England, Bonnie B. Punske, Sheldon E. Litwin
Publikováno v:
Journal of Electrocardiology. 38:40-44
Background Epicardial potentials reveal the strong effects of fiber anisotropy, rotation, imbrication, and coupling on propagation in the intact heart. From the patterns of the surface potentials, we can obtain information about the local fiber orien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f34164166f0ac2b12e11a13b773d78f
https://doi.org/10.1016/j.jelectrocard.2005.06.097
https://doi.org/10.1016/j.jelectrocard.2005.06.097
Publikováno v:
Journal of Cardiac Failure. 8:262-272
Background: Integrins are heterodimeric receptors that couple the extracellular matrix to intracellular signaling pathways and the cyoskeleton. Integrins are strain transducers and candidates for modulators or effectors of cardiac hypertrophy. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f716fe49f53cd715866cbc39f4e8e8d
https://doi.org/10.1054/jcaf.2002.127335
https://doi.org/10.1054/jcaf.2002.127335