Výsledky vyhledávání - "Maria L. Langdown"

Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort

Autor: Toby Andrew, Andreas Braun, P.W. Reed, Gabriela L. Surdulescu, Frank Dudbridge, Gail Isabel Reid Adam, Rikard Reneland, Scott Wilson, Maria Norberg, Patrick W. Kleyn, Maria L. Langdown, Tim D. Spector, Philip N. Sambrook

Publikováno v: European Journal of Human Genetics. 14:340-348

Obesity is a multifactorial disorder with a complex phenotype. It is a significant risk factor for diabetes and hypertension. We assessed obesity-related traits in a large cohort of twins and performed a genome-wide linkage scan and positional candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c276318e03e07426241f577a2e800ac8
https://doi.org/10.1038/sj.ejhg.5201551

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Comparison of Genome Screens for Two Independent Cohorts Provides Replication of Suggestive Linkage of Bone Mineral Density to 3p21 and 1p36

Autor: A. Bansal, Mathias Chiano, Scott Wilson, P.W. Kleyn, David B. Thompson, M. Bailey, M.M. Shi, Maria L. Langdown, P.W. Reed, Tim D. Spector, E. Thompson, Richard L. Prince, Philip N. Sambrook, M. Lindersson

Publikováno v: The American Journal of Human Genetics. 72:144-155

Low bone mineral density (BMD) is a major risk factor for osteoporotic fracture. Studies of BMD in families and twins have shown that this trait is under strong genetic control. To identify regions of the genome that contain quantitative trait loci (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62cf89516661a21e0892cf88befbb8d
https://doi.org/10.1086/345819

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Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation

Autor: Maria L. Langdown, Mary C. Sugden

Publikováno v: Molecular and Cellular Endocrinology. 185:119-126

Apoptosis contributes to uteroplacental dsyfunction in intrauterine growth retardation (IUGR). Specific protein kinase C (PKC) isoforms regulate apoptosis in other cell types. PKC isoforms thought to be anti-apoptotic include the conventional PKC iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7258fe873a8d7836ef0bfcd30c64d69e
https://doi.org/10.1016/s0303-7207(01)00630-x

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Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation

Autor: Mary C. Sugden, Maria L. Langdown

Publikováno v: Molecular and Cellular Endocrinology. 185:109-117

Intrauterine growth retardation (IUGR) increases the risk of developing glucose intolerance and cardiovascular disease in adulthood. Fetal exposure to excess glucocorticoids may contribute to IUGR. Despite the importance of glucose supply for fetal g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73b4368cdfe2d1dd722567a9e82adca
https://doi.org/10.1016/s0303-7207(01)00629-3

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Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring

Autor: Mary C. Sugden, Melinda J. Munns, Mark J. Holness, Maria L. Langdown

Publikováno v: European Journal of Endocrinology. :529-539

BACKGROUND: Leptin concentrations are increased during late pregnancy, and leptin receptors are expressed in placental and fetal tissues, suggesting a role for leptin in placental and/or fetal growth, or both. In humans, leptin concentrations in adul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41084b1eabe70a574c13fb800e97cd6b
https://doi.org/10.1530/eje.0.1450529

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Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood

Autor: Mark J. Holness, Mary C. Sugden, Maria L. Langdown

Publikováno v: Journal of Endocrinology. 169:11-22

In the rat, dexamethasone treatment during late pregnancy leads to intrauterine growth retardation and is used as a model of early programming of adult onset disease. The present study investigated whether pre-natal dexamethasone treatment modifies c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0330ceb5337bd3bfe25c7ef9dd43433c
https://doi.org/10.1677/joe.0.1690011

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Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply

Autor: M C Sugden, Maria L. Langdown, Robert A. Harris, M J Holness

Publikováno v: Biochemical Journal. 352:731-738

Activation of the pyruvate dehydrogenase (PDH) complex (PDHC) promotes glucose disposal, whereas inactivation conserves glucose. The PDH kinases (PDHKs) regulate glucose oxidation through inhibitory phosphorylation of PDHC. The adult rat heart contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::952969335ac7c27aa14b286e92824322
https://doi.org/10.1042/bj3520731

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Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling

Autor: Steven Mah, Deborah J. Hart, Tim D. Spector, Stefan Kammerer, Maria L. Langdown, Josephine M. Atienza, Ana M. Valdes, Carolyn R. Hoyal, Andreas Braun, Richard Reneland, Michael Doherty, Proton Rahman, Matthew R. Nelson

Publikováno v: Arthritis and rheumatism. 54(2)

Objective To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee. Methods We examined >25,000 SNPs located within ∼14,000 genes for associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d9b0b1018142871e35599ed904f461
https://pubmed.ncbi.nlm.nih.gov/16447229

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A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21

Autor: Mathias Chiano, M.J. Barber, P.W. Kleyn, Toby Andrew, E. Thompson, P.W. Reed, David B. Thompson, Tim D. Spector, Maria L. Langdown, M. Bailey, M. Lindersson, Scott Wilson

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19(2)

A genome-wide screen was performed on a large cohort of dizygous twin pairs to identify regions of the genome that contain QTL for QUS of bone. Suggestive linkage of QUS parameters to 2q33–37 and 4q12–21 highlighted these regions as potentially i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8edb4e05e0d5f10f7fae289477f23b
https://pubmed.ncbi.nlm.nih.gov/14969397

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Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood

Autor: Maria L. Langdown, Mary C. Sugden, Mark J. Holness

Overexpression of the conserved Ca2+-binding proteins calreticulin and calsequestrin impairs cardiac function, leading to premature death. Calreticulin is vital for embryonic development, but also impairs glucocorticoid action. Glucocorticoid overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b703b9d2ed4d688e02cd2697a8ee0f19
https://europepmc.org/articles/PMC1223268/

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