Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria L. Florez-McClure"'
Autor:
Chris Downing, Thomas E. Johnson, Maria L. Florez-McClure, Boris Tabakoff, Katerina Kechris, Stephen Flink
Publikováno v:
Alcoholism: Clinical and Experimental Research. 36:1519-1529
Prenatal alcohol exposure can result in fetal alcohol spectrum disorders (FASD). Not all women who consume alcohol during pregnancy have children with FASD and studies have shown that genetic factors can play a role in ethanol teratogenesis. We exami
Publikováno v:
Journal of Biological Chemistry. 284:20398-20407
Continuous macroautophagic activity is critical for the maintenance of neuronal homeostasis; however, unchecked or dysregulated autophagy can lead to cell death. Cultured Purkinje neurons die by an autophagy-associated cell death mechanism when depri
Autor:
Daniel A. Linseman, Ron J. Bouchard, Reid A. Phelps, Thomas A Precht, Brent D. Butts, Shoshona S. Le, Maria L. Florez-McClure, Tracey A. Laessig, Kim A. Heidenreich
Publikováno v:
The Journal of Neuroscience. 24:9993-10002
Glycogen synthase kinase-3β (GSK-3β) is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults. However, the downstream substrates of GSK-3β that ultimately induce neuronal death are unknown. Here, we show that
Autor:
Lindsay A. Hohsfield, Gin Fonte, Maria L. Florez-McClure, Christopher D. Link, Matthew T. Bealor
Publikováno v:
Autophagy. 3(6)
Autophagy is a conserved membrane trafficking pathway that mediates the delivery of cytoplasmic substrates to the lysosome for degradation. Impaired autophagic function is implicated in the pathology of various neurodegenerative diseases. We have gen
Autor:
Ron J. Bouchard, Brent D. Butts, Kim A. Heidenreich, Shoshona S. Le, Maria L. Florez-McClure, Daniel A. Linseman, F. Alexandra Loucks, Angela K. Zimmermann
Publikováno v:
Journal of neurochemistry. 94(1)
Primary cerebellar granule neurons (CGNs) require depolarizing extracellular potassium for their survival. Removal of depolarizing potassium triggers CGN apoptosis that requires induction of Bim, a BH3-only Bcl-2 family member. Bim is classically tho
Autor:
Daniel A. Linseman, Kim A. Heidenreich, Shoshona S. Le, Charleen T. Chu, Ron J. Bouchard, Maria L. Florez-McClure, Tracey A. Laessig, Phil A. Barker
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(19)
The cellular mechanisms underlying Purkinje neuron death in various neurodegenerative disorders of the cerebellum are poorly understood. Here we investigate anin vitromodel of cerebellar neuronal death. We report that cerebellar Purkinje neurons, dep
Publikováno v:
Autophagy. 5:132-133
(2009). Erratum to: Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans. Autophagy 2007; 3:569-80. Autophagy: Vol. 5, No. 1, pp. 13