Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Maria L, Webb"'
Autor:
Maria L. Webb, Ilana L. Stroke, Laurie J. Sturzenbecker, David W. Hilbert, Brett A. Marinelli, Joan E. Sabalski, Linh Ma, David J. Diller, Philip D. Stein, Jeffrey J. Letourneau, Jorge Quintero
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:756-761
The discovery, synthesis and preliminary structure-activity relationship (SAR) of a novel class of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB) is described. A high throughput screening (HTS) campaign resulted in the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f742445d139a1bd6814035c6c49dc34f
https://doi.org/10.1016/j.bmcl.2018.01.005
https://doi.org/10.1016/j.bmcl.2018.01.005
Autor:
Yanfang Li, Jeffrey J. Letourneau, Laurie J. Sturzenbecker, Maria L. Webb, Brett A. Marinelli, Philip D. Stein, Ilana L. Stroke, Linh Ma, Andrew G. Cole, Igor Pechik, Jorge Quintero, David W. Hilbert, Joan E. Sabalski
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(23-24)
Synthesis and structure-activity relationships (SAR) of a novel series of benzodiazepinedione-based inhibitors of Clostridium difficile toxin B (TcdB) are described. Compounds demonstrating low nanomolar affinity for TcdB, and which possess improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090c6be502149e94cd4e282caaf0f29c
https://pubmed.ncbi.nlm.nih.gov/30392779
https://pubmed.ncbi.nlm.nih.gov/30392779
Autor:
Joan E. Sabalski, Yan Xu, Philip D. Stein, Laurie J. Sturzenbecker, Jeffrey J. Letourneau, Teresa Miller, Ilana L. Stroke, Maria L. Webb, Diana R. Savoly, David W. Hilbert, Linh Ma, Igor Pechik
Publikováno v:
Antimicrobial agents and chemotherapy. 62(5)
Clostridium difficile infection (CDI) is the leading cause of hospital-acquired infectious diarrhea, with significant morbidity, mortality, and associated health care costs. The major risk factor for CDI is antimicrobial therapy, which disrupts the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab694a3cd02b2c6aab3e9bb9ef4ccd
https://pubmed.ncbi.nlm.nih.gov/29483125
https://pubmed.ncbi.nlm.nih.gov/29483125
Autor:
Richard Horuk, Ian Henderson, J. Robert Merritt, Belinda Nedjai, Nagarajan Vaidehi, Emma L. Wise, Anthony E. Klon, Ilana L. Stroke, Hubert Li, Maria L. Webb, Andrew G. Cole, James E. Pease
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of inflammatory disorders, including a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92c8dd3ff01b63759f33dcd233d7435
http://europepmc.org/articles/PMC3417418
http://europepmc.org/articles/PMC3417418
Autor:
Jack Pick, Mark Craighead, Heather A. Zanetakos, Jeffrey J. Letourneau, Rachel Milne, Hema Desai, Leigh Campbell-Wan, Jeremy Presland, Michael Ohlmeyer, James R. Baker, Nasrin Ansari, Ray Jui-Hsiang Chan, Cliona P MacSweeney, Douglas S. Auld, Maria L. Webb, Jiuqiao Zhao, Chris Riviello, J. Richard Morphy, Stuart A. Best, Irina Neagu, Susan Elizabeth Napier, Koc-Kan Ho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3813-3817
Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V1b antagonists are described. 2-(6-Aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide have been identified with low nanomolar affinity for the V1b recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644306305bb4a232c2c9422c904af22d
https://doi.org/10.1016/j.bmcl.2011.04.022
https://doi.org/10.1016/j.bmcl.2011.04.022
Autor:
Herman D. Lim, Douglas S. Auld, Maria L. Webb, Jac C. H. M. Wijkmans, Jiuqiao Zhao, Luc Roumen, Rob Leurs, Chris de Graaf, Petra de Kruijf, Martine J. Smit, Véronique A. Renjaän, G.J.R. Zaman
Publikováno v:
Molecular Pharmacology, 80, 1108-1118. American Society for Pharmacology and Experimental Therapeutics
de Kruijf, P, Lim, H D, Roumen, L, Renjaan, V A, Zhao, J, Webb, M J, Auld, D A, Wijkmans, J C H M, Zaman, G J R, Smit, M J, de Graaf, C & Leurs, R 2011, ' Identification of a novel allosteric binding site in the CXCR2 chemokine receptor ', Molecular Pharmacology, vol. 80, pp. 1108-1118 . https://doi.org/10.1124/mol.111.073825
de Kruijf, P, Lim, H D, Roumen, L, Renjaan, V A, Zhao, J, Webb, M J, Auld, D A, Wijkmans, J C H M, Zaman, G J R, Smit, M J, de Graaf, C & Leurs, R 2011, ' Identification of a novel allosteric binding site in the CXCR2 chemokine receptor ', Molecular Pharmacology, vol. 80, pp. 1108-1118 . https://doi.org/10.1124/mol.111.073825
We have shown previously that different chemical classes of small-molecule antagonists of the human chemokine CXCR2 receptor interact with distinct binding sites of the receptor. Although an intracellular binding site for diarylurea CXCR2 antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411a011ebb508fbe8e7aa0a7af6983a3
https://doi.org/10.1124/mol.111.073825
https://doi.org/10.1124/mol.111.073825
Autor:
W. Lynn Rogers, Brian F. Mcguinness, Kurt W. Saionz, Steven G. Kultgen, Vikash Srivastava, Hema Desai, Hao Yan, Tara M. Stauffer, Samiran Saha, Koc-Kan Ho, Shengting Zhang, Neelima Mannava, Yan Jiang, Anthony E. Klon, Tailong Li, Juxing Yin, Weiqing Chen, Konghua Jing, Maria L. Webb, Kanak Kanti Majumdar, Laura L. Rokosz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7414-7420
A novel series of quinolinone-based adenosine A2B receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3954d9929bb24932679a9f1fdf525fd0
https://doi.org/10.1016/j.bmcl.2010.10.030
https://doi.org/10.1016/j.bmcl.2010.10.030
Autor:
Andrew G. Cole, Douglas S. Auld, Riviello Christopher, Hema Desai, Hong Li, Heather A. Zanetakos, Fiona Thomson, J. Richard Morphy, Jiuqiao Zhao, Susan Elizabeth Napier, Michael Ohlmeyer, Katharine A. Goan, Koc-Kan Ho, Maria L. Webb, Jeffrey J. Letourneau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5394-5397
The discovery, synthesis, and preliminary structure–activity relationship (SAR) of a novel class of vasopressin V3 (V1b) receptor antagonists is described. Compound 1, identified by high throughput screening of a diverse, three million-member compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9cd65c56eed38d36dbec9326862276
https://doi.org/10.1016/j.bmcl.2010.07.118
https://doi.org/10.1016/j.bmcl.2010.07.118
Autor:
Debra G. Goodwin, Tarek S. Mansour, Kenneth C. Appell, Katherine J. Seidl, Amha G. Hewet, Maria L. Webb, Min Gao, James D. Clark, Steve Tam, Martin Hegen, Elizabeth Quadros, Peter T. Symanowicz, Jenny Togias, Jennifer Lussier, Scott H. Schelling, Michael Ohlmeyer, Bojing Wang, Xin Xu, Earl F. Kimble, Mary Collins, Jorge Quintero, Rustem Krykbaev, Dejun Xuan, Cheryl Nickerson-Nutter, Richard Harrison, Yuefei Shao, Christopher Wrocklage, Tsung H. Lin, Andrew G. Cole
Publikováno v:
Arthritis & Rheumatism. 62:2283-2293
Objective All γ-chain cytokines signal through JAK-3 and JAK-1 acting in tandem. We undertook this study to determine whether the JAK-3 selective inhibitor WYE-151650 would be sufficient to disrupt cytokine signaling and to ameliorate autoimmune dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef4a0c33e1ad1789a4ae6c55e946b7c
https://doi.org/10.1002/art.27536
https://doi.org/10.1002/art.27536
Autor:
Celia Kingsbury, Irina Neagu, Ming You, Haengsoon Park, Tsung H. Lin, Koc-Kan Ho, Elizabeth Quadros, Maria L. Webb, Michael Ohlmeyer, Yuefei Shao, Matthew Sills, Jeffrey J. Letourneau, Andrew G. Cole, Yingchun Lu, Earl F. Kimble, Jorge Quintero, Riviello Christopher, Ray Anthony James, Bojing Wang, Vidyadhar M. Paradkar, Adolph Bohnstedt, Kenneth C. Appell, David J. Diller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6788-6792
A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd21d26420d59e8a1c379ce66894ef1
https://doi.org/10.1016/j.bmcl.2009.09.080
https://doi.org/10.1016/j.bmcl.2009.09.080