Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Maria Koulmanda"'
Autor:
Sarantis Korniotis, Thomas B. Thornley, Periklis Kyriazis, Evangelos Theodorou, Lingzhi Ma, Lisa S. Li, Efi Kokkotou, Terry B. Strom, Maria Koulmanda
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Hematopoietic stem/progenitor cells (HSPC) are characterized by their unique capacities of self-renewal and multi-differentiation potential. This second property makes them able to adapt their differentiation profile depending on the local environmen
Externí odkaz:
https://doaj.org/article/a0d5ce8a92354ad28c33dcffe0c65131
Autor:
Tetsu Oura, Dicken S. C. Ko, Svjetlan Boskovic, John J. O'neil, Vaja Chipashvili, Maria Koulmanda, Kiyohiko Hotta, Kento Kawai, Ognjenka Nadazdin, R. Neal Smith, A. B. Cosimi, Tatsuo Kawai M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 25 (2016)
We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allograft
Externí odkaz:
https://doaj.org/article/c12157fb3b5749818096b09dc2adfafb
Autor:
Thomas B Thornley, Krishna A Agarwal, Periklis Kyriazis, Lingzhi Ma, Vaja Chipashvili, Jonathan E Aker, Sarantis Korniotis, Eva Csizmadia, Terry B Strom, Maria Koulmanda
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150792 (2016)
The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role of their tissue-resident coun
Externí odkaz:
https://doaj.org/article/1ee04bde033b4a88bda65b5fa8719471
Autor:
Klearchos K Papas, Melena D Bellin, David E R Sutherland, Thomas M Suszynski, Jennifer P Kitzmann, Efstathios S Avgoustiniatos, Angelika C Gruessner, Kathryn R Mueller, Gregory J Beilman, Appakalai N Balamurugan, Gopalakrishnan Loganathan, Clark K Colton, Maria Koulmanda, Gordon C Weir, Josh J Wilhelm, Dajun Qian, Joyce C Niland, Bernhard J Hering
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134428 (2015)
BackgroundReliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility of an assay based on cellular ox
Externí odkaz:
https://doaj.org/article/3b1106a0d9a04b4484572e0579606e02
Autor:
Maria Koulmanda, Manoj Bhasin, Zuheir Awdeh, Andi Qipo, Zhigang Fan, Dusan Hanidziar, Prabhakar Putheti, Hang Shi, Eva Csizuadia, Towia A Libermann, Terry B Strom
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33254 (2012)
Previously, we have demonstrated that short-term treatment of new onset diabetic Non-obese diabetic (NOD) mice, mice that are afflicted with both type 1 (T1D) and type 2 (T2D) diabetes with either Power Mix (PM) regimen or alpha1 antitrypsin (AAT) pe
Externí odkaz:
https://doaj.org/article/bbaaa6ac4b21445cb0ecc707ea19adc5
Autor:
John J. O'neil, Vaja Tchipashvili, Richard J. Parent, Obinna Ugochukwu, Gaurav Chandra, Maria Koulmanda, Dicken Ko, Tatsuo Kawai
Publikováno v:
Cell Transplantation, Vol 12 (2003)
Recent advances in islet cell transplantation have led to insulin independence in a majority of islet transplant recipients. However, there exists a need to overcome the shortage of donor tissue and the necessity for lifelong immunosuppression. Precl
Externí odkaz:
https://doaj.org/article/8ad7582215564914a75d7b0de82ae6de
Publikováno v:
American Journal of Transplantation
Limited availability of donor organs and risk of ischemia‐reperfusion injury (IRI) seriously restrict organ transplantation. Therapeutics that can prevent or reduce IRI could potentially increase the number of transplants by increasing use of borde
Autor:
Gordon C. Weir, Sai Kanaparthi, Brett Jepson, S. Alice Long, Kristina M. Harris, Lia J Weiner, Deborah Phippard, Terry B. Strom, Maria Koulmanda, James McNamara, Mario R. Ehlers
Publikováno v:
Pediatric Diabetes. 19:945-954
Objective To determine the safety and pharmacokinetics of alpha-1 antitrypsin (AAT) in adults and children. Research design and methods Short-term AAT treatment restores euglycemia in the non-obese mouse model of type 1 diabetes. A phase I multicente
Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator
Autor:
Ragai R. Mitry, Joanne Tang, Siddharth Sinha, Celine Filippi, Charlotte A. Lee, Emer Fitzpatrick, Anil Dhawan, Raquel Fernandez Dacosta, Simon Walker, Valeria Iansante, Maria Koulmanda, Robin D. Hughes
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient numbers of
Publikováno v:
Current Opinion in Organ Transplantation. 20:8-12
To update knowledge concerning the cause and consequences of the detrimental forms of innate immunity that inevitably occurs in peritransplant period tissue and cellular transplants. In addition, we review the information that a newly discovered, eng