Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Maria Kontoyianni"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/cd322d63f3ad448ca81be682c90732b2
Autor:
Olivia Slater, Maria Kontoyianni
Publikováno v:
SN Applied Sciences, Vol 4, Iss 5, Pp 1-19 (2022)
Abstract The somatostatin subtype-4 receptor (sst4) is highly expressed in neocortical and hippocampal areas, which are affected by amyloid beta accumulation. Sst4 agonists enhance downstream activity of amyloid beta peptide catabolism through nepril
Externí odkaz:
https://doaj.org/article/509926581c3c41a6aa396ad66f237ed7
Autor:
Alejandro M. S. Mayer, Mary L. Hall, Joseph Lach, Jonathan Clifford, Kevin Chandrasena, Caitlin Canton, Maria Kontoyianni, Yeun-Mun Choo, Dev Karan, Mark T. Hamann
Publikováno v:
Marine Drugs, Vol 19, Iss 9, p 506 (2021)
Manzamines are complex polycyclic marine-derived β-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivitie
Externí odkaz:
https://doaj.org/article/b3bab1dd54084d17be970cacbdcf5f09
Autor:
Maria, Kontoyianni
Publikováno v:
Expert Opinion on Drug Discovery. 17:1177-1179
Autor:
Olivia Slater, Kapur B. Dhami, Ganesh Shrestha, Maria Kontoyianni, Michael R. Nichols, Alexei V. Demchenko
Publikováno v:
ACS Infect Dis
Sepsis is a serious medical condition characterized by bacterial infection and a subsequent massive systemic inflammatory response. In an effort to identify compounds that block lipopolysaccharide (LPS)-induced inflammation reported herein is the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850fe349441a73af2495ff7a9bd060f8
https://europepmc.org/articles/PMC9402072/
https://europepmc.org/articles/PMC9402072/
Autor:
William L. Neumann, Karin E. Sandoval, Shirin Mobayen, Mahsa Minaeian, Stephen G. Kukielski, Khush N. Srabony, Rafael Frare, Olivia Slater, Susan A. Farr, Michael L. Niehoff, Audrey Hospital, Maria Kontoyianni, A. Michael Crider, Ken A. Witt
Publikováno v:
RSC Med Chem
Somatostatin receptor-4 (SST(4)) is highly expressed in brain regions affiliated with learning and memory. SST(4) agonist treatment may act to mitigate Alzheimer's disease (AD) pathology. An integrated approach to SST(4) agonist lead optimization is
Autor:
Maria Kontoyianni
Publikováno v:
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a38316f1926c3fa6f4225c94be91e236
https://doi.org/10.1016/b978-0-12-820472-6.00042-6
https://doi.org/10.1016/b978-0-12-820472-6.00042-6
Publikováno v:
Microsoft Academic Graph
Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and g
Autor:
Maria Kontoyianni, Olivia Slater
Publikováno v:
Expert Opinion on Drug Discovery. 14:619-637
Introduction: Docking and structure-based virtual screening (VS) have been standard approaches in structure-based design for over two decades. However, our understanding of the limitations, potential, and strength of these techniques has enhanced, ra
A series of compounds containing a 1,2,4-triazole moiety were synthesized, targeting the somatostatin receptor subtype-4 (sst(4)). Compounds were developed in which the Phe(6)/Phe(7)/Phe(11), Trp(8), and Lys(9) mimetic groups were interchanged at pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b851edb34da59fe68a4305d265d3c8c9
https://europepmc.org/articles/PMC6336083/
https://europepmc.org/articles/PMC6336083/