A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures

Autor: Maria Kondratova, Urszula Czerwinska, Nicolas Sompairac, Sebastian D. Amigorena, Vassili Soumelis, Emmanuel Barillot, Andrei Zinovyev, Inna Kuperstein

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The complexity of the innate immune response to cancer makes interpretation of large data sets challenging. Here, the authors provide an integrated multi-scale map of signalling networks representing the different immune cells and their interactions

Externí odkaz: https://doaj.org/article/d431490a7031492db83471392f547ffe

A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures

Autor: Urszula Czerwinska, Sebastian Amigorena, Nicolas Sompairac, Emmanuel Barillot, Andrei Zinovyev, Maria Kondratova, Inna Kuperstein, Vassili Soumelis

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The lack of integrated resources depicting the complexity of the innate immune response in cancer represents a bottleneck for high-throughput data interpretation. To address this challenge, we perform a systematic manual literature mining of molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14fcf6d28cdd5abba6e1adcf6da9ccb
http://europepmc.org/articles/PMC6805895

Application of Atlas of Cancer Signalling Network in pre-clinical studies

Autor: L. Cristobal Monraz Gomez, Jean-Marie Ravel, Andrei Zinovyev, Inna Kuperstein, Maria Kondratova, Emmanuel Barillot

Initiation and progression of cancer involve multiple molecular mechanisms. The knowledge on these mechanisms is expanding and should be converted into guidelines for tackling the disease. We discuss here formalization of biological knowledge into a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a748343e7aae961f37052ec8fbf5912a

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Autor: Yann Kieffer, Claire Bonneau, Inna Kuperstein, Anne Vincent-Salomon, Laetitia Fuhrmann, Ana Catarina Costa, Fatima Mechta-Grigoriou, Anne-Marie Givel, Vassili Soumelis, Ilaria Magagna, Maria Carla Parrini, Andrei Zinovyev, Alix Scholer-Dahirel, Melissa Cardon, Philémon Sirven, Brigitte Bourachot, Maria Kondratova, Charles Bernard, Floriane Pelon

Publikováno v: Cancer Cell
Cancer Cell, 2018, 33 (3), pp.463-479.e10. ⟨10.1016/j.ccell.2018.01.011⟩
Cancer Cell, Elsevier, 2018, 33 (3), pp.463-479.e10. ⟨10.1016/j.ccell.2018.01.011⟩

Comment inBreast cancer: Fibroblast subtypes alter the microenvironment. [Nat Rev Clin Oncol. 2018]; International audience; Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment. Here, we characterize four CAF subsets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8d21dd877774adcbf38291c18dd280
https://pubmed.ncbi.nlm.nih.gov/29508858

EtpB Is a Pore-Forming Outer Membrane Protein Showing TpsB Protein Features Involved in the Two-Partner Secretion System

Autor: Laurent Coquet, Maria Kondratova, Andrey V. Kajava, Nathalie Saint, Albano C. Meli, Virginie Molle

Publikováno v: Journal of Membrane Biology
Journal of Membrane Biology, Springer Verlag (Germany), 2009, 230 (3), pp.143-154. ⟨10.1007/s00232-009-9195-z⟩
Journal of Membrane Biology, Springer Verlag (Germany), 2009, 230 (3), pp.143-54. ⟨10.1007/s00232-009-9195-z⟩
Journal of Membrane Biology, 2009, 230 (3), pp.143-54. ⟨10.1007/s00232-009-9195-z⟩

International audience; Attachment to host tissues is a critical step in the pathogenesis of most bacterial infections. Enterotoxigenic Escherichia coli (ETEC) remains one of the principal causes of infectious diarrhea in humans. The recent identific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c459e638d265c2e1f0a006f9e976775a
https://doi.org/10.1007/s00232-009-9195-z