Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maria Koltun"'
Autor:
Michael D. Edstein, Peter Conrad Healy, Anna Campbell, Scott Blundell, Tina S. Skinner-Adams, Rohan A. Davis, Ronald J. Quinn, Brett D. Schwartz, Rebecca H. Pouwer, Karren D. Beattie, Maria Koltun, Donna Mackenzie, Katherine T. Andrews, Susan A. Charman, Mark J. Coster
Publikováno v:
Organic & Biomolecular Chemistry. 13:1558-1570
A series of amide (8–32, 40–45) and urea (33, 34, 36–39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against chloroquine-sensitive (3D7) and chloroquine- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4940de954a482ddabbd15add60bf330
https://doi.org/10.1039/c4ob01849d
https://doi.org/10.1039/c4ob01849d
Publikováno v:
American Journal of Physiology-Renal Physiology. 307:F525-F532
Albuminuria in nephrotic states is thought to arise from the formation of large pores in the glomerular capillary wall as large hydrodynamic probes, like Ficoll, have increased fractional clearance. In the present study, we tested for large pore form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba97ef02d9a6f40dc8aedc48f474f08
https://doi.org/10.1152/ajprenal.00228.2014
https://doi.org/10.1152/ajprenal.00228.2014
Autor:
Ivo Santana Caldas, Karolina R. Gonçalves, Luiz F. Marques, David M. Shackleford, Ana Lia Mazzeti, Eric Chatelain, Álvaro Fernando da Silva do Nascimento, Ludmilla Walter Reis Mota, Lívia de Figueiredo Diniz, Karen L. White, Maria Koltun, Jessica Saunders, Ivan Scandale, Susan A. Charman, André Talvani, Maria Terezinha Bahia
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4362-4370
This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of Chagas disease. Female Swiss mice infected with the Y strain of Trypanosoma cruzi were treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec17f99cd6c25b9ecaeb4c8b39ab2967
https://doi.org/10.1128/aac.02754-13
https://doi.org/10.1128/aac.02754-13
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Jonathan L. Vennerstrom, Heinrich Urwyler, Sergio Wittlin, Yuxiang Dong, Darren J. Creek, Yuanqing Tang, Arnulf Dorn, Kamaraj Sriraghavan, Christopher Snyder, Julia Morizzi, Reto Brun, Maniyan Padmanilayam, Maria Koltun, Susan A. Charman, William N. Charman, Jacques Chollet, Xiaofang Wang, Hugues Matile, Josefina Santo Tomas, Christian Scheurer
Publikováno v:
Journal of Medicinal Chemistry. 53:481-491
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups were not required for high antimalarial potency, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597e9be51453d7021377a69512c5262a
https://doi.org/10.1021/jm901473s
https://doi.org/10.1021/jm901473s
Autor:
Kasiram Katneni, Sreekanth Kokkonda, Susan A. Charman, Elizabeth J. Goldsmith, Jeremy N. Burrows, María Belén Jiménez-Díaz, Ravi K. Bhamidipati, Margaret A. Phillips, William N. Charman, Xiaoyi Deng, Iñigo Angulo-Barturen, David M. Floyd, Jose M. Coteron, David Matthews, Francisco-Javier Gamo, Jorge Esquivias, Pradipsinh K. Rathod, John H. White, Farah El Mazouni, Karen L. White, Santiago Ferrer, David M. Shackleford, Maria Koltun, Maria L. Marco, Ian Bathurst
Publikováno v:
Journal of medicinal chemistry. 54(15)
Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance. In an effort to identify new potential anti-malarials we have undertaken a lead optimization program around our previously identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c1dee444ff5d3b96693e69fe178114
https://pubmed.ncbi.nlm.nih.gov/21696174
https://pubmed.ncbi.nlm.nih.gov/21696174
Autor:
Kasiram Katneni, Michelle P. McIntosh, Julia Morizzi, Susan A. Charman, Maria Koltun, David M. Shackleford
Publikováno v:
Biopharmaceuticsdrug disposition. 31(8-9)
The aim of this work was to evaluate the impact of sulfobutyl ether β-cyclodextrin ((SBE)7 m-β-CD; Captisol®) on the in vivo pharmacokinetics of melphalan in rats. Melphalan is a chemically unstable antineoplastic drug which in the current commerc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a131da3db4418adfda57f45fff51d
https://pubmed.ncbi.nlm.nih.gov/20865695
https://pubmed.ncbi.nlm.nih.gov/20865695
Autor:
Maria Koltun, Wayne D. Comper
Publikováno v:
Microcirculation (New York, N.Y. : 1994). 11(4)
To examine the role of renal processing in the turnover of circulating albumin in the model of reversible overload proteinuria. Specifically, this study determines whether proteinuria due to hyperalbuminemia may be attributed to saturation of renal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3adb1961754eb603e8c7470bcd303f4
https://pubmed.ncbi.nlm.nih.gov/15280074
https://pubmed.ncbi.nlm.nih.gov/15280074