Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Maria Koehler"'
Autor:
Ben O’Leary, Sarah Hrebien, James P. Morden, Matthew Beaney, Charlotte Fribbens, Xin Huang, Yuan Liu, Cynthia Huang Bartlett, Maria Koehler, Massimo Cristofanilli, Isaac Garcia-Murillas, Judith M. Bliss, Nicholas C. Turner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Circulating tumor DNA (ctDNA) may provide a prediction of treatment response, but could be impacted by tumor heterogeneity. Here, the authors investigate ctDNA in CDK4/6 inhibitor treatment in advanced breast cancer, finding ctDNA levels predict prog
Externí odkaz:
https://doaj.org/article/fe55104b6a3946c08222bef99156c284
Autor:
Dominik Glodzik, Pier Selenica, Ryan A. Rogge, Ian M. Silverman, Diana Mandelker, Sam Harris, Jianhua Zhao, Michael Zinda, Artur Veloso, Nirav Malani, Nadeem Riaz, Maria Koehler, Robert D. Daber, Verity Johnson, Victoria Rimkunas, Jorge S. Reis-Filho
Publikováno v:
The Journal of Molecular Diagnostics. 25:295-310
Autor:
José Baselga, Neal Rosen, Joaquin Arribas, David Cameron, Charles Geyer, Henry Gomez, Maria Koehler, Robert Gagnon, Catherine Ellis, Josep Lluis Parra, Marta Guzman, Gertrudis Sánchez, Pier Davide Angelini, José Jimenez, Claudia Aura, Ludmila Prudkin, Sarat Chandarlapaty, Maurizio Scaltriti
Supplementary Data from Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2–Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ab4055c3c0afbef48f7ad680292f73
https://doi.org/10.1158/1078-0432.22442855.v1
https://doi.org/10.1158/1078-0432.22442855.v1
Autor:
José Baselga, Neal Rosen, Joaquin Arribas, David Cameron, Charles Geyer, Henry Gomez, Maria Koehler, Robert Gagnon, Catherine Ellis, Josep Lluis Parra, Marta Guzman, Gertrudis Sánchez, Pier Davide Angelini, José Jimenez, Claudia Aura, Ludmila Prudkin, Sarat Chandarlapaty, Maurizio Scaltriti
Purpose: A subgroup of human epidermal growth factor receptor 2 (HER2)–overexpressing breast tumors coexpresses p95HER2, a truncated HER2 receptor that retains a highly functional HER2 kinase domain but lacks the extracellular domain and results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a837f5e32a513948c40bba407b6363d6
https://doi.org/10.1158/1078-0432.c.6519506
https://doi.org/10.1158/1078-0432.c.6519506
Autor:
Matthew J. Ellis, Souzan Sanati, Hussam Al-Kateb, Maria Koehler, Cynthia Huang Bartlett, Kiran Vij, Caroline Bumb, Shana Thomas, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Michelle V. Lee, Zhanfang Guo, Helen Krontiras, Tina Hieken, Timothy J. Eberlein, Amy Cyr, William Gillanders, Timothy Moynihan, Timothy Hobday, Rebecca Aft, Julie Margenthaler, Karen S. Anderson, Rama Suresh, Foluso Ademuyiwa, Michael Naughton, Jeremy Hoog, Andres Forero, Matthew Goetz, Donald W. Northfelt, Jingqin Luo, Feng Gao, Cynthia X. Ma
Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) assessed the antiproliferative activity of the CDK4/6 inhibitor palbocicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5405b1d4db6a955a56275a7511589430
https://doi.org/10.1158/1078-0432.c.6527120.v1
https://doi.org/10.1158/1078-0432.c.6527120.v1
Autor:
Matthew J. Ellis, Souzan Sanati, Hussam Al-Kateb, Maria Koehler, Cynthia Huang Bartlett, Kiran Vij, Caroline Bumb, Shana Thomas, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Michelle V. Lee, Zhanfang Guo, Helen Krontiras, Tina Hieken, Timothy J. Eberlein, Amy Cyr, William Gillanders, Timothy Moynihan, Timothy Hobday, Rebecca Aft, Julie Margenthaler, Karen S. Anderson, Rama Suresh, Foluso Ademuyiwa, Michael Naughton, Jeremy Hoog, Andres Forero, Matthew Goetz, Donald W. Northfelt, Jingqin Luo, Feng Gao, Cynthia X. Ma
Supplementary Table S1 describes the AE profile, Supplementary S2 shows the results of clinical and radiologic responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cca1c1f8b032e5e78aa7b2f2ef837cc
https://doi.org/10.1158/1078-0432.22468994.v1
https://doi.org/10.1158/1078-0432.22468994.v1
Autor:
Matthew J. Ellis, Souzan Sanati, Hussam Al-Kateb, Maria Koehler, Cynthia Huang Bartlett, Kiran Vij, Caroline Bumb, Shana Thomas, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Michelle V. Lee, Zhanfang Guo, Helen Krontiras, Tina Hieken, Timothy J. Eberlein, Amy Cyr, William Gillanders, Timothy Moynihan, Timothy Hobday, Rebecca Aft, Julie Margenthaler, Karen S. Anderson, Rama Suresh, Foluso Ademuyiwa, Michael Naughton, Jeremy Hoog, Andres Forero, Matthew Goetz, Donald W. Northfelt, Jingqin Luo, Feng Gao, Cynthia X. Ma
Supplementary Table S3 provides the result of the 83-gene panel next generation sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040ddc618e60063cfbe632e5978b5a92
https://doi.org/10.1158/1078-0432.22469018.v1
https://doi.org/10.1158/1078-0432.22469018.v1
Autor:
Dennis J. Slamon, Lynn C. Hartmann, Maria Koehler, Sophia Randolph, William A. Cliby, Darren Riehle, Victor E. Velculescu, Siân Jones, Charles Ginther, Richard S. Finn, Kimberly R. Kalli, Lee Anderson, He-Jing Wang, Meenal Chalukya, Guorong Yang, Judy Dering, Kanthinh Manivong, Jingwei Qi, Teodora Kolarova, Boris Winterhoff, Gottfried E. Konecny
Supplementary Figure S1; Supplementary Table S1; Supplementary Tables S3-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d11590bef772561ecd68ef7470e7a5
https://doi.org/10.1158/1078-0432.22442225
https://doi.org/10.1158/1078-0432.22442225
Autor:
Dennis J. Slamon, Lynn C. Hartmann, Maria Koehler, Sophia Randolph, William A. Cliby, Darren Riehle, Victor E. Velculescu, Siân Jones, Charles Ginther, Richard S. Finn, Kimberly R. Kalli, Lee Anderson, He-Jing Wang, Meenal Chalukya, Guorong Yang, Judy Dering, Kanthinh Manivong, Jingwei Qi, Teodora Kolarova, Boris Winterhoff, Gottfried E. Konecny
Purpose: PD-0332991 is a selective inhibitor of the CDK4/6 kinases with the ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar range. Here we investigate the role of CDK4/6 inhibition in human ovarian cancer.Experimental Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9260835bb20b3b189128155d7addb3
https://doi.org/10.1158/1078-0432.c.6519020.v1
https://doi.org/10.1158/1078-0432.c.6519020.v1
Autor:
Matthew J. Ellis, Souzan Sanati, Hussam Al-Kateb, Maria Koehler, Cynthia Huang Bartlett, Kiran Vij, Caroline Bumb, Shana Thomas, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Michelle V. Lee, Zhanfang Guo, Helen Krontiras, Tina Hieken, Timothy J. Eberlein, Amy Cyr, William Gillanders, Timothy Moynihan, Timothy Hobday, Rebecca Aft, Julie Margenthaler, Karen S. Anderson, Rama Suresh, Foluso Ademuyiwa, Michael Naughton, Jeremy Hoog, Andres Forero, Matthew Goetz, Donald W. Northfelt, Jingqin Luo, Feng Gao, Cynthia X. Ma
Supplementary Fig. S1 is the consort diagram; Supplementary Fig. S2 describes the clinicopathologic and molecular features of the 6 palbociclib resistant tumors; Supplementary Fig S3 shows the proliferation score and correlation with Ki67 at each tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22268477815d8fe72dfb3af9b768a9a0
https://doi.org/10.1158/1078-0432.22469024.v1
https://doi.org/10.1158/1078-0432.22469024.v1