PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults

Autor: Nicola Fenwick, Rebekah Weston, Keith Wheatley, Jodie Hodgson, Lynley Marshall, Martin Elliott, Guy Makin, Antony Ng, Bernadette Brennan, Stephen Lowis, Jenny Adamski, John Paul Kilday, Rachel Cox, Mike Gattens, Andrew Moore, Toby Trahair, Milind Ronghe, Martin Campbell, Helen Campbell, Molly W. Williams, Maria Kirby, Natasha Van Eijkelenburg, Jennifer Keely, Ugo Scarpa, Victoria Stavrou, Livingstone Fultang, Sarah Booth, Paul Cheng, Carmela De Santo, Francis Mussai

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundThe survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the pathophysiology of a number of pediatric cancers. We report the first in child study of

Externí odkaz: https://doaj.org/article/4902b15b11094343be86c12a848d2cb8

Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis

Autor: Susan L. Heatley, Elyse C. Page, Laura N. Eadie, Barbara J. McClure, Jacqueline Rehn, David T. Yeung, Michael Osborn, Tamas Revesz, Maria Kirby, Deborah L. White

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Children with neurofibromatosis have a higher risk of developing juvenile myelomonocytic leukemia and acute myeloid leukemia, but rarely develop B-cell acute lymphoblastic leukemia (B-ALL). Through in-vitro modeling, a novel NF1 p.L2467 frameshift (f

Externí odkaz: https://doaj.org/article/9f2434c287fe47c995543bb044e7f78d

Malignant Melanoma in Children and Adolescents Treated in Pediatric Oncology Centers: An Australian and New Zealand Children’s Oncology Group (ANZCHOG) Study

Autor: Geoff McCowage, Maria Kirby, Rishi S. Kotecha, Jordan R. Hansford, Aditya Kumar Gupta, Peter Downie, David S. Ziegler, Tim Hassall, Charlotte Burns, Stephen J. Laughton, Frank Alvaro, Anne L. Ryan, Nicholas G. Gottardo, Ruvishani Samarasekera, Siobhan Cross

Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology

ObjectivesUnlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e184666af25d88244e95f90f760f25e
https://www.frontiersin.org/articles/10.3389/fonc.2021.660172/full

International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma

Autor: John Caird, Stephanie Francis, Rachid Drissi, Chris Jones, Anahid Ehteda, Maria Vinci, Cynthia Hawkins, Jordan R. Hansford, Darach Crimmins, Alexander Plessier, Dannis G. van Vuurden, Tim Hassall, Danielle Upton, Bing Liu, David Castel, Jane Pears, Jane Cryan, Michael Farrell, Louise E. Ludlow, Esther Hulleman, Diana Carvalho, Michelle Monje, Chelsea Mayoh, Michaël H. Meel, Maria Tsoli, Jacques Grill, Andrea Carai, Maryam Fouladi, Maria Kirby, David S. Ziegler, Angela Mastronuzzi, Nicholas G. Gottardo, Han Shen, Laura Franshaw

Publikováno v: Tsoli, M, Shen, H, Mayoh, C, Franshaw, L, Ehteda, A, Upton, D, Carvalho, D, Vinci, M, Meel, M H, van Vuurden, D, Plessier, A, Castel, D, Drissi, R, Farrell, M, Cryan, J, Crimmins, D, Caird, J, Pears, J, Francis, S, Ludlow, L E A, Carai, A, Mastronuzzi, A, Liu, B, Hansford, J, Gottardo, N, Hassall, T, Kirby, M, Fouladi, M, Hawkins, C, Monje, M, Grill, J, Jones, C, Hulleman, E & Ziegler, D S 2019, ' International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma ', Journal of Neuro-Oncology, vol. 141, no. 2, pp. 253-263 . https://doi.org/10.1007/s11060-018-03038-2
Journal of Neuro-Oncology, 141(2), 253-263. Kluwer Academic Publishers

Purpose: Diffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlying biology, and lack of represen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e31056b998d3a562d033852735ebe2b
https://doi.org/10.1007/s11060-018-03038-2

Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis

Autor: Jacqueline Rehn, David T Yeung, Deborah L. White, Elyse C. Page, Susan L. Heatley, Michael Osborn, Tamas Revesz, Maria Kirby, Barbara J. McClure, Laura N Eadie

Publikováno v: Blood. 138:1317-1317

Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder affecting approximately 1:3000 individuals globally. While approximately 50% are familial, with over 3000 causative germline variants in the neurofibromatosis (NF1) gene identified, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b55b0f75079e9d13c687d041f47d5d0
https://doi.org/10.1182/blood-2021-150086