Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Maria Kasper"'
Autor:
Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.
Externí odkaz:
https://doaj.org/article/15ce094130ad4d1185c37a3fd0a60446
Autor:
Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper, Geert van Loo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of
Externí odkaz:
https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance.
Autor:
Anton J M Larsson, Christoph Ziegenhain, Michael Hagemann-Jensen, Björn Reinius, Tina Jacob, Tim Dalessandri, Gert-Jan Hendriks, Maria Kasper, Rickard Sandberg
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008772 (2021)
Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic
Externí odkaz:
https://doaj.org/article/34266d00cadf45e0b0c24c11ceee3b37
Autor:
Yi Zhang, Karl Annusver, Kazunori Sunadome, Polina Kameneva, Steven Edwards, Guanghua Lei, Maria Kasper, Andrei S. Chagin, Igor Adameyko, Meng Xie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
A joint connects two or more bones together to form a functional unit that allows different types of bending and movement. Little is known about how the opposing ends of the connected bones are developed. Here, applying various lineage tracing strate
Externí odkaz:
https://doaj.org/article/4b0ebd06ef924a9598f912b80cab529d
Autor:
Xiaoyan Sun, Alexandra Are, Karl Annusver, Unnikrishnan Sivan, Tina Jacob, Tim Dalessandri, Simon Joost, Anja Füllgrabe, Marco Gerling, Maria Kasper
Publikováno v:
eLife, Vol 9 (2020)
Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we
Externí odkaz:
https://doaj.org/article/e5a8e803ef724159ae6387f916f7d0e4
Autor:
Juan R. Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén, Jurga Laurencikiene
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-6 (2017)
Abstract Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASCs with different differentiation
Externí odkaz:
https://doaj.org/article/6b3adb523481403fa689ec1e398a945a
Autor:
Anja Füllgrabe, Simon Joost, Alexandra Are, Tina Jacob, Unnikrishnan Sivan, Andrea Haegebarth, Sten Linnarsson, Benjamin D. Simons, Hans Clevers, Rune Toftgård, Maria Kasper
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 843-855 (2015)
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study, we used multicolor lineage tracing to mark Lgr6-expr
Externí odkaz:
https://doaj.org/article/236350be9ef3410da8d307bbf455eb10
Autor:
Simon Joost, Tina Jacob, Xiaoyan Sun, Karl Annusver, Gioele La Manno, Inderpreet Sur, Maria Kasper
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 585-597.e7 (2018)
Summary: Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elus
Externí odkaz:
https://doaj.org/article/1b6a32585feb4cfeab83362f0dd516a7
Autor:
Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko
Publikováno v:
eLife, Vol 7 (2018)
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signa
Externí odkaz:
https://doaj.org/article/7bcb1b81e55b4002b8070e7d9c19b9f0
Publikováno v:
Revista NUPEM, Vol 15, Iss 36, Pp 71-78 (2023)
O presente estudo aborda aspectos do processo de desterritorialização de um educador-pesquisador, vivenciados entre 2017 e 2023, período em que passou a cartografar seus processos e devires. Utilizou-se, para tanto, uma metodologia pensada com Del
Externí odkaz:
https://doaj.org/article/8f9a21f52f6b40e2b3bb164ed297eccd