Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maria Kasherman"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Marija Kojic, Tomasz Gawda, Monika Gaik, Alexander Begg, Anna Salerno-Kochan, Nyoman D. Kurniawan, Alun Jones, Katarzyna Drożdżyk, Anna Kościelniak, Andrzej Chramiec-Głąbik, Soroor Hediyeh-Zadeh, Maria Kasherman, Woo Jun Shim, Enakshi Sinniah, Laura A. Genovesi, Rannvá K. Abrahamsen, Christina D. Fenger, Camilla G. Madsen, Julie S. Cohen, Ali Fatemi, Zornitza Stark, Sebastian Lunke, Joy Lee, Jonas K. Hansen, Martin F. Boxill, Boris Keren, Isabelle Marey, Margarita S. Saenz, Kathleen Brown, Suzanne A. Alexander, Sergey Mureev, Alina Batzilla, Melissa J. Davis, Michael Piper, Mikael Bodén, Thomas H. J. Burne, Nathan J. Palpant, Rikke S. Møller, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stabi
Externí odkaz:
https://doaj.org/article/04bbd860a4c34da0ae14a920e50e23e1
Autor:
Danyon Harkins, Tracey J. Harvey, Cooper Atterton, Ingrid Miller, Laura Currey, Sabrina Oishi, Maria Kasherman, Raul Ayala Davila, Lucy Harris, Kathryn Green, Hannah Piper, Robert G. Parton, Stefan Thor, Helen M. Cooper, Michael Piper
Publikováno v:
Cells, Vol 11, Iss 15, p 2377 (2022)
Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricles. Prev
Externí odkaz:
https://doaj.org/article/5e119d222a894d89991f619199713ad6
Heterozygosity for Nuclear Factor One X in mice models features of Malan syndromeResearch in context
Autor:
Sabrina Oishi, Danyon Harkins, Nyoman D. Kurniawan, Maria Kasherman, Lachlan Harris, Oressia Zalucki, Richard M. Gronostajski, Thomas H.J. Burne, Michael Piper
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 388-400 (2019)
Background: Nuclear Factor One X (NFIX) haploinsufficiency in humans results in Malan syndrome, a disorder characterized by overgrowth, macrocephaly and intellectual disability. Although clinical assessments have determined the underlying symptomolog
Externí odkaz:
https://doaj.org/article/24d77e45fada4e82a4a45207064c7dc1
Autor:
Nyoman D. Kurniawan, Margarita Saenz, Melissa J. Davis, Anna Salerno-Kochan, Julie S. Cohen, Sebastian Glatt, Anna Kościelniak, Ali Fatemi, Mikael Bodén, Martin F. Boxill, Joy Lee, Woo Jun Shim, Nathan J. Palpant, Tomasz Gawda, Jonas K. Hansen, Katarzyna Drożdżyk, Alexander Begg, Rikke S. Møller, Michael Piper, Marija Kojic, Soroor Hediyeh-Zadeh, Thomas H. J. Burne, Brandon J. Wainwright, Kathleen Brown, Isabelle Marey, Sergey Mureev, Rannvá K. Abrahamsen, Enakshi Sinniah, Zornitza Stark, Laura A. Genovesi, Monika Gaik, Andrzej Chramiec-Głąbik, Suzanne Alexander, Alun Jones, Alina Batzilla, Christina Fenger, Camilla Gøbel Madsen, Maria Kasherman, Boris Keren, Sebastian Lunke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Kojic, M, Gawda, T, Gaik, M, Begg, A, Salerno-Kochan, A, Kurniawan, N D, Jones, A, Drożdżyk, K, Kościelniak, A, Chramiec-Głąbik, A, Hediyeh-Zadeh, S, Kasherman, M, Shim, W J, Sinniah, E, Genovesi, L A, Abrahamsen, R K, Fenger, C D, Madsen, C G, Cohen, J S, Fatemi, A, Stark, Z, Lunke, S, Lee, J, Hansen, J K, Boxill, M F, Keren, B, Marey, I, Saenz, M S, Brown, K, Alexander, S A, Mureev, S, Batzilla, A, Davis, M J, Piper, M, Bodén, M, Burne, T H J, Palpant, N J, Møller, R S, Glatt, S & Wainwright, B J 2021, ' Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype ', Nature Communications, vol. 12, 2678 . https://doi.org/10.1038/s41467-021-22888-5
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in intellectual and adaptive functioning, with their genetic and molecular basis remainin
Autor:
Danyon, Harkins, Tracey J, Harvey, Cooper, Atterton, Ingrid, Miller, Laura, Currey, Sabrina, Oishi, Maria, Kasherman, Raul Ayala, Davila, Lucy, Harris, Kathryn, Green, Hannah, Piper, Robert G, Parton, Stefan, Thor, Helen M, Cooper, Michael, Piper
Publikováno v:
Cells. 11(15)
Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of
Publikováno v:
Molecular Neurobiology. 57:2179-2193
Intellectual disability (ID) and autism spectrum disorder (ASD) are two of the most common neurodevelopmental disorders. Both disorders are extremely heterogenous, and only ~ 40% of reported cases have so far been attributed to genetic mutations. Of
Autor:
Danyon Harkins, Richard M. Gronostajski, Maria Kasherman, Michael Piper, Thomas H. J. Burne, Lachlan Harris, Sabrina Oishi, Nyoman D. Kurniawan, Oressia Zalucki
Publikováno v:
EBioMedicine
Background Nuclear Factor One X (NFIX) haploinsufficiency in humans results in Malan syndrome, a disorder characterized by overgrowth, macrocephaly and intellectual disability. Although clinical assessments have determined the underlying symptomology
Autor:
Jeremy C. Brownlie, Kelly M Toppinen, Michael W. Weible, Michael D. Lovelace, Hannah C Leeson, Maria Kasherman, Ben J. Gu, Tailoi Chan-Ling
Publikováno v:
Stem Cells (Dayton, Ohio)
Identifying the signaling mechanisms that regulate adult neurogenesis is essential to understanding how the brain may respond to neuro-inflammatory events. P2X7 receptors can regulate pro-inflammatory responses, and in addition to their role as catio
Autor:
Nyoman D. Kurniawan, Oressia Zalucki, Maria Kasherman, Thomas H. J. Burne, Michelle C. Sanchez Vega, Stephen A. Wood, Michael Piper, Lachlan A. Jolly, Laura Currey
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 31(3)
Genetic association studies have identified many factors associated with neurodevelopmental disorders such as autism spectrum disorder (ASD). However, the way these genes shape neuroanatomical structure and connectivity is poorly understood. Recent r