Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maria Karvela"'
Autor:
Maria Karvela, Caroline T. Golden, Nikeysha Bell, Stephanie Martin-Li, Judith Bedzo-Nutakor, Natalie Bosnic, Pierre DeBeaudrap, Sara de Mateo-Lopez, Ahmed Alajrami, Yun Qin, Maria Eze, Tsz-Kin Hon, Javier Simón-Sánchez, Rashmita Sahoo, Jonathan Pearson-Stuttard, Patrick Soon-Shiong, Christofer Toumazou, Nick Oliver
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Dietary interventions can reduce progression to type 2 diabetes mellitus (T2DM) in people with non-diabetic hyperglycaemia. In this study we aimed to determine the impact of a DNA-personalised nutrition intervention in people with non-diabet
Externí odkaz:
https://doaj.org/article/e05df0ddfee54e139b6845a090910cdd
Autor:
Alison Burdett, Christofer Toumazou, Rashmita Sahoo, Adam Mujan, Tsz-Kin Hon, Judith Bedzo-Nutakor, Nicola Casali, Maria Karvela, Mohammadreza Sohbati, Graham S. Cooke, Gary W. Davies, Luke S. P. Moore
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background As SARS-CoV-2 testing expands, particularly to widespread asymptomatic testing, high sensitivity point-of-care PCR platforms may optimise potential benefits from pooling multiple patients’ samples. Method We tested patients and
Externí odkaz:
https://doaj.org/article/bc53b5644c1a483691cdbaacf5a078ee
Autor:
Malick M Gibani, D Phil, Christofer Toumazou, ProfPhD, Mohammadreza Sohbati, PhD, Rashmita Sahoo, PhD, Maria Karvela, PhD, Tsz-Kin Hon, PhD, Sara De Mateo, PhD, Alison Burdett, PhD, K Y Felice Leung, PhD, Jake Barnett, MSc, Arman Orbeladze, MSc, Song Luan, PhD, Stavros Pournias, MSc, Jiayang Sun, MSc, Barney Flower, MRCP, Judith Bedzo-Nutakor, BSc, Maisarah Amran, MBBS, Rachael Quinlan, BSc, Keira Skolimowska, PhD, Carolina Herrera, PhD, Aileen Rowan, PhD, Anjna Badhan, PhD, Robert Klaber, MD, Gary Davies, MD, David Muir, FRCPath, Paul Randell, FRCPath, Derrick Crook, ProfFRCPath, Graham P Taylor, ProfDSc, Wendy Barclay, ProfPhD, Nabeela Mughal, FRCPath, Luke S P Moore, PhD, Katie Jeffery, PhD, Graham S Cooke, ProfFRCP
Publikováno v:
The Lancet Microbe, Vol 1, Iss 7, Pp e300-e307 (2020)
Summary: Background: Access to rapid diagnosis is key to the control and management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory RT-PCR testing is the current standard of care but usually requires a centralised laborato
Externí odkaz:
https://doaj.org/article/ba7cf87426b64d74bba421864b9724f8
Autor:
Stephen W.G. Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L. Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R. Green
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 878-885 (2013)
Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effe
Externí odkaz:
https://doaj.org/article/3bac1bef9e604f5e88b84218c1ad4f99
Publikováno v:
IEEE Journal of Biomedical and Health Informatics. 24:3276-3284
Intensive attention on personalised skin-health solutions is on account of incomparable love of skin and an urgent need for effective treatment. In the meanwhile, people have great expectations on how to utilise genetic knowledge of our body to provi
Autor:
Christofer Toumazou, Adam Mujan, Nicola Casali, Rashmita Sahoo, Judith Bedzo-Nutakor, Alison Burdett, Tsz-Kin Hon, Mohammadreza Sohbati, Luke S. P. Moore, Graham S Cooke, Maria Karvela, Gary W Davies
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Infectious Diseases
BMC Infectious Diseases
Background As SARS-CoV-2 testing expands, particularly to widespread asymptomatic testing, high sensitivity point-of-care PCR platforms may optimise potential benefits from pooling multiple patients’ samples. Method We tested patients and asymptoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03f58d51b2a4acbc7d5f4fa6815ef28
http://hdl.handle.net/10044/1/90294
http://hdl.handle.net/10044/1/90294
Autor:
Graham P. Taylor, Sara de Mateo, Rachael Quinlan, Gary W Davies, Jiayang Sun, Mohammadreza Sohbati, Rashmita Sahoo, Christofer Toumazou, Arman Orbeladze, Nabeela Mughal, Song Luan, David Muir, Paul Randell, Derrick W. Crook, Jake Barnett, Robert Klaber, Barnaby Flower, Keira H. Skolimowska, Maria Karvela, Alison Burdett, Maisarah Amran, K. Y.Felice Leung, Malick M. Gibani, Tsz-Kin Hon, Graham S Cooke, Judith Bedzo-Nutakor, Wendy S. Barclay, Luke S. P. Moore, Katie Jeffery, Stavros Pournias
3.ABSTRACTBackgroundAccess to rapid diagnosis is key to the control and management of SARS-CoV-2. Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) testing usually requires a centralised laboratory and significant infrastructure. We describe t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf88f8d42c3aa7952ec040308a38067
https://doi.org/10.1101/2020.08.13.20174193
https://doi.org/10.1101/2020.08.13.20174193
Publikováno v:
IEEE transactions on biomedical circuits and systems. 12(1)
The rise of personalized diets is due to the emergence of nutrigenetics and genetic tests services. However, the recommendation system is far from mature to provide personalized food suggestion to consumers for daily usage. The main barrier of connec
Autor:
Rebecca Mitchell, Tessa L. Holyoake, Elaine K. Allan, Kamil R. Kranc, Maria Karvela, G. Vignir Helgason, Arunima Mukhopadhyay, Eyal Gottlieb, Elodie M. Kuntz, Pablo Baquero, Edmond Chan, Paolo Salomoni, Bruno Calabretta
Publikováno v:
Karvela, M, Baquero, P, Kuntz, E, Mukhopadhyay, A, Mitchell, R, Allan, E, Chan, E, Kranc, K, Calabretta, B, Salomoni, P, Gottlieb, E, Holyoake, T L & Helgason, G V 2016, ' ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells ', Autophagy . < http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1162359 >
Autophagy
Autophagy
A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitive CML cells are able to survive TKI-mediated BCR-ABL inhibition, leading to disease persistence in patients. Investigation of strategies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8ccb8988abf6303efb98461c3f76e3
https://hdl.handle.net/11380/1134534
https://hdl.handle.net/11380/1134534
Publikováno v:
Expert Review of Anticancer Therapy. 12:381-392
Chronic myeloid leukemia is a stem cell-initiated but progenitor-driven disease induced by the BCR-ABL oncogene. Tyrosine kinase inhibitors (TKIs) were introduced in the late 1990s and have revolutionized the management of chronic myeloid leukemia in