Výsledky vyhledávání - "Maria Kalyukina"

Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4

Autor: Xiaojing Lin, Yuliana Yosaatmadja, Maria Kalyukina, Martin J. Middleditch, Zhen Zhang, Xiaoyun Lu, Ke Ding, Adam V. Patterson, Jeff B. Smaill, Christopher J. Squire

Publikováno v: ACS Med Chem Lett

[Image: see text] Aberration in FGFR4 signaling drives carcinogenesis and progression in a subset of hepatocellular carcinoma (HCC) patients, thereby making FGFR4 an attractive molecular target for this disease. Selective FGFR4 inhibition can be achi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200419c850590b39124ba936fda0d528
https://doi.org/10.1021/acsmedchemlett.9b00196

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TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

Autor: Adam V. Patterson, Yuliana Yosaatmadja, Martin Middleditch, Maria Kalyukina, Jeff B. Smaill, Christopher J. Squire

Publikováno v: ChemMedChem. 14(4)

1-[(3S)-3-[4-Amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one (TAS-120) is an irreversible inhibitor of the fibroblast growth factor receptor (FGFR) family, and is currently under phase I/II cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af69bf23b45802ebc571293bd333e88a
https://pubmed.ncbi.nlm.nih.gov/30600916

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