Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria K. Tsoumpra"'
Autor:
Maria K. Tsoumpra, Seiji Fukumoto, Toshio Matsumoto, Shin'ichi Takeda, Matthew J.A. Wood, Yoshitsugu Aoki
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 630-645 (2019)
Duchenne muscular dystrophy (DMD) is an X-linked disorder characterized by progressive muscle degeneration, caused by the absence of dystrophin. Exon skipping by antisense oligonucleotides (ASOs) has recently gained recognition as therapeutic approac
Externí odkaz:
https://doaj.org/article/739d7a44d5fe4d228349a3110189ed36
Autor:
Shouta Miyatake, Yoshitaka Mizobe, Maria K. Tsoumpra, Kenji Rowel Q. Lim, Yuko Hara, Fazel Shabanpoor, Toshifumi Yokota, Shin’ichi Takeda, Yoshitsugu Aoki
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 520-535 (2019)
Exon skipping using phosphorodiamidate morpholino oligomers (PMOs) is a promising treatment strategy for Duchenne muscular dystrophy (DMD). The most significant limitation of these clinically used compounds is their lack of delivery systems that targ
Externí odkaz:
https://doaj.org/article/8adfbe071288407f91a199fc44e59c6c
Autor:
Toshio Matsumoto, Shun Sawatsubashi, Yoshitsugu Aoki, Michihiro Imamura, Shin'ichi Takeda, Seiji Fukumoto, Maria K. Tsoumpra
Publikováno v:
Journal of Molecular Endocrinology. 64:195-208
The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3), exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recog
Publikováno v:
Journal of Bone and Mineral Metabolism. 38:1-6
Abnormal phosphate levels result in several pathological conditions such as rickets/osteomalacia and ectopic calcification indicating that there must be a system that regulates phosphate level within a narrow range. FGF23 has been shown to be an esse
Autor:
Seiji Fukumoto, Hiroshi Sakaue, Go Shioi, Tomoki Nakashima, Risa Kainuma, Shigeaki Kato, Masahiro Abe, Shun Sawatsubashi, Yuichi Takashi, Toshio Matsumoto, Bingzi Dong, Itsuro Endo, Maria K. Tsoumpra, Hiroshi Kiyonari, Yukiyo Ohnishi, Masahiro Hiasa, Takeshi Kondo
Exercise offers mechanical loading to the bone, while it stimulates energy expenditure in the adipose tissue. Thus, bone may secrete a factor to communicate with adipose tissue in response to mechanical loading. Interleukin (IL)-11 is expressed in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e20b679173eb1663fe2924c98fd457f
https://doi.org/10.21203/rs.3.rs-888146/v1
https://doi.org/10.21203/rs.3.rs-888146/v1
Autor:
Nobuaki Ito, Masaomi Nangaku, Shigeaki Kato, Hidetaka Kosako, Maria K. Tsoumpra, Masahiro Abe, Yuka Kinoshita, Seiji Fukumoto, Munehide Matsuhisa, Shun Sawatsubashi, Yuichi Takashi, Toshio Matsumoto
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phosphate (Pi) is essential for life; thus, serum Pi level is kept constant under tight regulation by fibroblast growth factor (FGF) 23. Conversely, serum FGF23 levels are also controlled by sensing Pi alterations in serum, but this Pi-s
Autor:
Yoshitsugu Aoki, A Arzumanov, Kamel Mamchaoui, Tone Yuichiro, Rika Maruyama, Graham McClorey, Shin'ichi Takeda, Toshifumi Yokota, Yasumasa Hashimoto, Maria K. Tsoumpra, Michihiro Imamura, Vincent Mouly, Michael J. Gait, Matthew J.A. Wood, Reiko Terada
Publikováno v:
Nucleic Acid Therapeutics
Nucleic Acid Therapeutics, 2021, 31 (2), pp.172-181. ⟨10.1089/nat.2020.0907⟩
Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. publishers, 2021, 31 (2), pp.172-181. ⟨10.1089/nat.2020.0907⟩
Nucleic Acid Therapeutics, 2021, 31 (2), pp.172-181. ⟨10.1089/nat.2020.0907⟩
Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. publishers, 2021, 31 (2), pp.172-181. ⟨10.1089/nat.2020.0907⟩
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by frameshift or nonsense mutations in the DMD gene, resulting in the loss of dystrophin from muscle membranes. Exon skipping using splice-switching oligonucleotides (SSOs) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6bb92dfaba5985c0590e408a2e368
https://hal.sorbonne-universite.fr/hal-03276095
https://hal.sorbonne-universite.fr/hal-03276095
Publikováno v:
Methods in Molecular Biology ISBN: 9781493986507
Antisense oligonucleotide induced exon skipping emerges as a promising therapeutic strategy for patients suffering from a devastating muscle disorder Duchenne muscular dystrophy (DMD). Systemic administration of antisense phosphorodiamidate morpholin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd03002eae378c3fb6d1e61f16b63d3b
https://doi.org/10.1007/978-1-4939-8651-4_9
https://doi.org/10.1007/978-1-4939-8651-4_9
Autor:
R. Graham G. Russell, Maria K. Tsoumpra, Michelle A. Lawson, Andrew D. Chantry, Frank H. Ebetino, Michael Pazianas
Publikováno v:
The Duration and Safety of Osteoporosis Treatment ISBN: 9783319236384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3db8a1d21caefe55ab80b25b22c8d8
https://doi.org/10.1007/978-3-319-23639-1_2
https://doi.org/10.1007/978-3-319-23639-1_2
Autor:
Maria K, Tsoumpra, Joao R, Muniz, Bobby L, Barnett, Aaron A, Kwaasi, Ewa S, Pilka, Kathryn L, Kavanagh, Artem, Evdokimov, Richard L, Walter, Frank, Von Delft, Frank H, Ebetino, Udo, Oppermann, R Graham G, Russell, James E, Dunford
Publikováno v:
Bone
Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues