Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Maria Josep Bellmunt"'
Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis
Autor:
Daniel Cacabelos, Victòria Ayala, Ana Belén Granado-Serrano, Mariona Jové, Pascual Torres, Jordi Boada, Rosanna Cabré, Omar Ramírez-Núñez, Hugo Gonzalo, Aranzazu Soler-Cantero, José Carlos Enrique Serrano, Maria Josep Bellmunt, María Paz Romero, María José Motilva, Takashi Nonaka, Masato Hasegawa, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Neurobiology of Disease, Vol 88, Iss , Pp 148-160 (2016)
Background: Docosahexaenoic acid (DHA), a key lipid in nervous system homeostasis, is depleted in the spinal cord of sporadic amyotrophic lateral sclerosis (sALS) patients. However, the basis for such loss was unknown. Methods: DHA synthetic machiner
Externí odkaz:
https://doaj.org/article/522bb7b3ed7f4a11b872e14ef1be0ab6
Autor:
Reinald Pamplona, Manuel Portero-Otín, David Riba, Cristina Ruiz, Joan Prat, Maria Josep Bellmunt, Gustavo Barja
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 10, Pp 1989-1994 (1998)
The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. Accordingly, the fatty
Externí odkaz:
https://doaj.org/article/895e58443db04f6a878cfdda15cea143
Autor:
Arantza Soler-Cantero, Mariona Jové, Daniel Cacabelos, Jordi Boada, Alba Naudí, Maria-Paz Romero, Anna Cassanyé, José C E Serrano, Lluis Arola, Josep Valls, Maria Josep Bellmunt, Joan Prat, Reinald Pamplona, Manuel Portero-Otin, Maria-José Motilva
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43308 (2012)
Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine-protein carbonyl reaction to 21 different plant-derived phenol
Externí odkaz:
https://doaj.org/article/3706c32d8e16467faa4682f1c07eabd0
Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis
Autor:
Maria-José Motilva, Ana Belén Granado-Serrano, María Paz Romero, Hugo Gonzalo, Daniel Cacabelos, Manuel Portero-Otin, Jordi Boada, Masato Hasegawa, Rosanna Cabré, Omar Ramírez-Núñez, Aranzazu Soler-Cantero, Maria Josep Bellmunt, Reinald Pamplona, Isidre Ferrer, Victoria Ayala, Pascual Torres, Mariona Jové, Takashi Nonaka, José Carlos Enrique Serrano
Publikováno v:
Neurobiology of Disease, Vol 88, Iss, Pp 148-160 (2016)
Background: Docosahexaenoic acid (DHA), a key lipid in nervous system homeostasis, is depleted in the spinal cord of sporadic amyotrophic lateral sclerosis (sALS) patients. However, the basis for such loss was unknown. Methods: DHA synthetic machiner
Autor:
Omar Ramírez-Núñez, Jordi Boada, Isidro Ferrer, Reinald Pamplona, Rosanna Cabré, Gisela Nadal-Rey, Ana Belén Granado-Serrano, Maria Josep Bellmunt, Manuel Portero-Otin, José C. E. Serrano, Daniel Cacabelos, Victoria Ayala
Publikováno v:
NeuroMolecular Medicine. 16:669-685
The implication of lipid peroxidation in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) derive from high abundance of peroxidation-prone polyunsaturated fatty acids in central nervous system and its relatively low antioxida
Autor:
Isidre Ferrer, Reinald Pamplona, Esther Dalfó, Victoria Ayala, Ekaterina V. Ilieva, Manuel Portero-Otin, Daniel Cacabelos, Maria Josep Bellmunt
Publikováno v:
Annals of the New York Academy of Sciences. 1126:315-319
Nonenzymatic protein modifications are generated from direct oxidation of amino acid side chains and from reaction of the nucleophilic side chains of specific amino acids with reactive carbonyl species. These reactions give rise to specific markers t
Autor:
Victoria Ayala, Maria Josep Bellmunt, Ekaterina V. Ilieva, Mariona Jové, Isidre Ferrer, Daniel Cacabelos, Reinald Pamplona, Mònica Povedano, Esther Dalfó, Manuel Portero-Otin
Publikováno v:
Brain. 130:3111-3123
The occurrence of endoplasmic reticulum (ER) stress in the sporadic form of amyotrophic lateral sclerosis (ALS) is unknown, despite it has been recently documented in experimental models of the familial form. Here we show that spinal cord from patien
Autor:
J.R. Requena, Elvira Fernández, E. Vasileva, Joan Prat, Maria Josep Bellmunt, M.T. Modol, Victoria Ayala, M. Portero-Otin, Reinald Pamplona
Publikováno v:
Revista Española de Geriatría y Gerontología. 41:48-54
Resumen Objetivos el proceso de envejecimiento afecta a todos los organismos y es de suponer que sus mecanismos basicos esten conservados entre especies. La oxidacion de proteinas se ha propuesto como uno de estos mecanismos basicos enlazando los rad
Autor:
Victoria Ayala, Reinald Pamplona, Esther Dalfó, Maria Josep Bellmunt, Joan Prat, Manuel Portero-Otin, Isidre Ferrer
Publikováno v:
Journal of Biological Chemistry. 280:21522-21530
Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes for these reactions is lackin
Publikováno v:
ResearcherID
It is assumed that increased oxidative stress contributes to the development of complications in diabetes. In this study, several markers of protein structural modifications directly induced by free radicals were investigated in the liver and kidney