A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

Autor: Syamala Rani Thimmiraju, Rakesh Adhikari, JeAnna R. Redd, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L. Uzcategui, Shannon E. Ronca, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-5 (2024)

Abstract The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV,

Externí odkaz: https://doaj.org/article/44e886df60de4b48bf25ffd2242f40b2

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

Autor: Peter J. Hotez, Rakesh Adhikari, Wen-Hsiang Chen, Yi-Lin Chen, Portia Gillespie, Nelufa Y. Islam, Brian Keegan, Rakhi Tyagi Kundu, Jungsoon Lee, Zhuyun Liu, Jason T. Kimata, Numan Oezguen, Jeroen Pollet, Cristina Poveda, Kay Razavi, Shannon E. Ronca, Ulrich Strych, Syamala R. Thimmiraju, Leroy Versteeg, Maria Jose Villar-Mondragon, Junfei Wei, Bin Zhan, Maria Elena Bottazzi

Publikováno v: Expert Review of Vaccines, Vol 22, Iss 1, Pp 495-500 (2023)

Introduction The development of a yeast-expressed recombinant protein-based vaccine technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine for global access is described. The proof-of-concept for developing a SARS-CoV-

Externí odkaz: https://doaj.org/article/9dc912870f71410b853d29ac8af90252

Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection

Autor: Kathryn M. Jones, Bin Zhan, Keenan J. Ernste, Maria Jose Villar, Nalini Bisht, Duc Nguyen, Li-Yen Chang, Cristina Poveda, Gonteria J. Robinson, Akshar J. Trivedi, Colby J. Hofferek, William K. Decker, Vanaja Konduri

Publikováno v: Frontiers in Parasitology, Vol 2 (2023)

IntroductionHookworms are parasitic helminths that secrete a variety of proteins that induce anti-inflammatory immune responses, stimulating increased CD4+Foxp3+ regulatory T cells and IL-10 production. Hookworm-derived recombinant proteins AIP-1 and

Externí odkaz: https://doaj.org/article/43335705601e4681a9aff69c665c95ea

A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2

Autor: Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Rakhi Kundu, Yi-Lin Chen, Suman Sharma, Karm Ghei, Brian Keegan, Leroy Versteeg, Portia M. Gillespie, Allan Ciciriello, Nelufa Y. Islam, Cristina Poveda, Nestor Uzcategui, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet

Publikováno v: Vaccines, Vol 11, Iss 10, p 1557 (2023)

(1) Background: We previously reported the development of a recombinant protein SARS-CoV-2 vaccine, consisting of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, adjuvanted with aluminum hydroxide (alum) and CpG oligonucleotides. I

Externí odkaz: https://doaj.org/article/e8dbfb4ddd6846bc8029464d5b8e6255

The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients

Autor: Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrián Daneri-Navarro, Bettina Müller, Carlos Velazquez, Elsa B. Alcoba, Isabel Alonso, Daniela B. Alves da Quinta, Renata Binato, Alicia Inés Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Juan M. Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raúl Delgadillo-Cisterna, Lucía Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A. Fernández, Jorge Fernández, Wanda Fernández, Ramón A. Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gómez, Gonzalo Greif, Thomas G. Gross, Marisol Guerrero, Marianne K. Henderson, Miguel E. Lopez-Muñoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andrés J. Morán-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A. Ortiz-Martínez, Jael Quintero, Antonio Quintero-Ramos, Rui M. Reis, Javier Retamales, Ernesto Rivera-Claisse, Darío Rocha, Robinson Rodríguez, Cristina Rosales, Efrain Salas-González, Verónica Sanchotena, Laura Segovia, Juan Martín Sendoya, Aida A. Silva-García, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, United States-Latin American Cancer Research Network (US-LACRN), Osvaldo L. Podhajcer, Juan Abarca, Pamela Acevedo, Graciela Acosta, Gissel Acosta, Gabriela Acosta Haab, Ana Lilian Acosta Silva, Marta Aghazarian, Carola Aguayo, Bernardo Aizen, Gustavo Alarcon Lopez, Liz Almeida, Ana Alvarez, Viviane Andrade, Wenceslao Angeles-Bueno, Roberto Arai, Priscila Elvira Arambula Barreras, Ma. Isabel Aramburo Rubio, Gonzalo Ardao, Lilia A. Arellano-Jimenez, Claudia Arias, Ricardo Armisen, Mauricio Aspee, Rodrigo Assar, Itzel Reneé Astiazarán Rascón, Sebastian Astorga, Maxwell Aviles Rodriguez, Antônio Bailão Junior, Adolfo E. Barragan-Curiel, Adelfo Barragan-Ruiz, Fernanda Bermudez, Julia Bernachin, Wilfrido Bernal Herrera, Mara Bonet, Sarah Brnich, Claudio Bustamante, Miguel Angel Bustamante, Julio Bustos-Gomez, Felipe de J Bustos-Rodriguez, Janett Caballero Jasso, Angie Calfuman, Antonio Hugo José Froes Marques, Mónica Campos, Soledad Cano, Juan C. Canton-Romero, Ricardo Cappetta, Paulina Carmona, Fernando Carrizo, André Lopes Carvalho, Erika Carvallo, Julio Carzoglio, Monica Casalnuovo, Benedicta Caserta, Alvaro Castillo, César Castillo, Roger Chammas, Mario Alberto Chavez Zamudio, Loreto Chia, Elisa Chiarello, Daniela Chirico, Esther Cisneros-Quirarter, Minor Raul Cordero Bautista, Valeria Cornejo, Baldemar Corral Villegas, Andrés Cortés, Sandra Cortés, Laura Cortes-Sanabria, German Salvador Cortez Zamorano, Alejandro Corvalan, Adolfo Cruz, Alba d'Aurora, Sandra De la Fuente, Soledad De la Peña, Roberto de Leon Caballero, Mirian de Souza, César Del Castillo, Azucena Del-Toro-Valero, Mirtha Di Pretoro, Andrea Digonzelli, Jose El Ters, Paula Escobar, Marcela Estolaza, Adriane Feijo Evangelista, Marcelo Fanelli, Paulo Farias, Graciela Fernandez, José R. Filassi, Natalia Filgueiras, Diego Flaks, Edgar G. Flores-Ayala, Maria R. Flores-Marquez, David Franco Hughes, Karina Franco-Topete, Jimena Freire, Cristobal Fresno, Romina Gabrielli, Mario Gallegos, Jorge Gamboa, Daiana Ganiewich, Carlos Garbovesky, Ruben Alejandro Garcia Munguia, Ricardo Garcia-Gaeta, Alma C. Garcia-Martinez, Liliana Gimenez, Hector Gómez Silveira, Mariana M. Gomez-Del Toro, Marcela Gonzalez, Alicia Gonzalez, Germán González, Cesar Osbaldo Gonzalez Mondaca, Leivy P. Gonzalez-Ramirez, Beatriz Gonzalez-Ulloa, Susana Gorostidy, Mariela Grass, Alfonso G. Guevara Torres, Lorena Gutierrez, Susan A. Gutierrez-Rubio, Adrián Hannois, Andrew Hart, Steffen Härtel, Marcos Henriquez, Rafael Hernandez Guevara, Miriam E. Hernandez-Franco, Manuel I. Herrera-Miramontes, Graciela Horton, Gladys Ibañez, Martín Ipiña, Beatriz Jalfin, Lilian Jara, Raul Jara, Maria Luisa Jaramillo, David Javalera-Castro, Maria Eugenia Jimenez, Hugo Ju, Nazareth Juárez Rusjan, Karen Juneman, Ligia Maria Kerr, Alejandra Krupelis, Flor Esmeralda Larios-Jimenez, Jose Domingo Latorre, Guillermo Laviña, Fernando Lavista, Irma Leticia León Duarte, Alberto Lescano, Verónica Lezano, Rossana Mendoza Lopez, Jose Guillermo Lopez Cervantes, Miguel Enrique Lopez Muñoz, Dora Loria, Alejandra Luque, Alejandro Maass, Maria do Socorro Maciel, Flavia Rotea Mangone, Jorge Mansilla, Katherine Marcelain, Carolina Mariani, Marcia Maria Chiquitelli Marques, Reyna J. Martinez-Arriaga, Hector R. Martinez-Ramirez, Marcela Martins, Alma G. Maya-Gonzalez, Brenda Mazzaferri, Yadira Medina-Mora, Mariana Menini, Silvia Míguez, Soledad Milans, Soledad Montes, Ana Verónica Morales Hernández, Giberto Morga-Villela, Carla Morong, Homero Muñoz, Ignacio Miguel Muse, Carina Mussetti, Eduardo Mussetti, Luis J. Najar-Acosta, Elisa Napolitano e Ferreira, Nancy E. Navarro-Ruiz, Cristina Noblía, João Soares Nunes, Daniela Núñez, Fabiola Núñez, Nilton Onari, Emma M. Oropeza-De Anda, David Ortega Tirado, Cynthia Aparecida Bueno de Toledo Osório, Carlos Eduardo Paiva, Paulina Peñaloza, Miguel Peredo-Navarro, David Pereira, Laura Perez Michel, Francisca Pino, Tania Pino, Natalia Pinto, Jessica Pizarro, Carlos Pressa, Enrique Ramirez, Gladys E. Ramirez-Rosales, Claudia Ramis, Maritza Ramos-Ramirez, Adela Rascon Alcantar, Silvana Ravaglio, Francois Richard, Omar Rios Méndez, Ramón Enrique Robles Zepeda, Iara Santana Rocha, Natalia Rodriguez, Vilma Rodriguez, Maria Teresa Rodriguez, Diego Rodriguez-Gonzalez, Rosemeire A Roela, Ana M Romero-Gomez, Ana M Rosales-Sandoval, Omar V Rubio-Plascencia, Florencia Russo, Gaciela Sabini, Isabel Saffie, Helena Salina Dias, Brenda Guadalupe Samaniego Soto, Julio San Martino, Benito Sanchez-Llamas, Daniel Sat-Muñoz, Mariana Savignano, Cristovam Scapulatempo Neto, Max Mano Senna, Carolina Silva, Jaime Silvera, Isabele Small, Fernando Soares, Iberê Soares, Silvana Soares dos Santos, Evandro Sobrosa de Mello, José Antonio Sola, Irene Sorín, Alejandra Sosa, Anabella Sosa, Claudio Sosa, Sandra Soto, Cristiano de Pádua Souza, Lucía Spangenberg, Gustavo Steffanof, Florencia Straminsky, Mónica Tapia, Raziel O. Tapia-Llanos, Geronimo M. Tavares-Macias, Guillermo Temperley, Veronica Terzieff, Vicente Teti, Javier Tognarelli, Verónica Toledo, Paulina Toro, Roberto Torres, Mariana Torres-Palomares, Rogelio Troyo-San Roman, Hernan Urbano, Nicolas Vacca, Daniel Vaimberg, María Lourdes Valencia Peña, Maria Lujan Vaselevich, Jaime Vazquez-Nares, Ezequiel Velez-Gomez, Laura N. Venegas-Godinez, Patricia Vercelli, Ricardo Verdugo, René Aloisio da Costa Vieira, Marta Vilensky, María José Villarubias, Manuel Isaac Villegas Gómez, Stella Viña, Silvia Vornetti, Anapaula Hidemi Uema Watanabe, Carlos Zamorano, Luis Zapata, Zdenka Zlatar

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with th

Externí odkaz: https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e