Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Autor: Maria José Chiabai, Juliana Franco Almeida, Mariana Gabriela Dantas de Azevedo, Suelen Soares Fernandes, Vanessa Bastos Pereira, Raffael Júnio Araújo de Castro, Márcio Sousa Jerônimo, Isabel Garcia Sousa, Leonora Maciel de Souza Vianna, Anderson Miyoshi, Anamelia Lorenzetti Bocca, Andrea Queiroz Maranhão, Marcelo Macedo Brigido

Publikováno v: BMC Biotechnology, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects.

Externí odkaz: https://doaj.org/article/0ec68aed5e3847a9b7f0506a0a7468e0

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice.

Autor: Chiabai, Maria José¹ (AUTHOR) mchiabai@hotmail.com, Almeida, Juliana Franco² (AUTHOR) jfa1911@gmail.com, de Azevedo, Mariana Gabriela Dantas¹ (AUTHOR) marianaus13@hotmail.com, Fernandes, Suelen Soares¹ (AUTHOR) suelensfernandes@outlook.com, Pereira, Vanessa Bastos³ (AUTHOR) vanessabastospereira@yahoo.com.br, de Castro, Raffael Júnio Araújo⁴ (AUTHOR) raffaeljunio@yahoo.com.br, Jerônimo, Márcio Sousa⁴ (AUTHOR) marciosj@gmail.com, Sousa, Isabel Garcia¹ (AUTHOR) isagarsousa@gmail.com, de Souza Vianna, Leonora Maciel⁵ (AUTHOR) leonoravianna@hotmail.com, Miyoshi, Anderson³ (AUTHOR) miyoshi@icb.ufmg.br, Bocca, Anamelia Lorenzetti⁴ (AUTHOR) anamelia.bocca@gmail.com, Maranhão, Andrea Queiroz^1,6 (AUTHOR) andreaqm@unb.br, Brigido, Marcelo Macedo^1,6 (AUTHOR) brigido@unb.br

Publikováno v: BMC Biotechnology. 6/25/2019, Vol. 19 Issue 1, p1-12. 12p.