Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Maria Jimenez-Sanchez"'
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/2b288fcdbef24653b6354a24b830f7bc
Autor:
Beatriz G. Perez-Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vazquez-Villasenor, Maria Jimenez-Sanchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo, Wendy Noble
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of AD brain. This l
Externí odkaz:
https://doaj.org/article/d262341bcc2d4dd5ae59b2b8156cdf4d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/e14c6664c42b4be0a70b9e6361213a1f
Autor:
Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and c
Externí odkaz:
https://doaj.org/article/faadda18e0ed4177b4aba46493d7b981
Autor:
Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 deple
Externí odkaz:
https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b838972
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225763 (2019)
There is extensive evidence of gender inequality in research leading to insufficient representation of women in leadership positions. Numbers revealing a gender gap in research are periodically reported by national and international institutions but
Externí odkaz:
https://doaj.org/article/a40dcd7b2e9b49fdba947551299da2ce
Autor:
Beatrice Paola Festa, Farah H. Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C. Rubinsztein
In neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. Our work aims to investigate how this paracrine signaling affects neuronal function. Here, we show that activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179a9f5a4fa0cfae51048a9b30f2113
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impai
Externí odkaz:
https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850
Autor:
Vittoria Matafora, Alena Gorb, Wendy Noble, Angela Bachi, Beatriz Gomez Perez-Nievas, Maria Jimenez-Sanchez
Astrocytes associate with amyloid plaques in Alzheimer’s disease (AD). Astrocytes react to changes in the brain environment, including to increasing concentrations of amyloid-ß (Aß). However, the precise response of astrocytes to soluble small A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b724c636f2b4e554c6c769d435437c1b
https://doi.org/10.1101/2023.01.18.523916
https://doi.org/10.1101/2023.01.18.523916
Autor:
Paula Beltran-Lobo, Matthew J. Reid, Maria Jimenez-Sanchez, Alexei Verkhratsky, Beatriz G. Perez-Nievas, Wendy Noble
Publikováno v:
King's College London
Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS). They undertake numerous functions during development and in adulthood to support and protect the brain through finely regulated communication with other cellular