Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria Jenni Petersson"'
Autor:
Stephanie S Schweiker, Maria Jenni Petersson, Anna S. Lohning, Ian D. Jenkins, Wendy Anne Loughlin
Publikováno v:
European Journal of Medicinal Chemistry. 84:584-594
A series of morpholine substituted amino acids (phenylalanine, leucine, lysine and glutamic acid) was synthesized. A fragment-based screening approach was then used to evaluate a series of small heterocycles, including morpholine, oxazoline, dihydro-
Publikováno v:
Org. Biomol. Chem.. 7:739-746
Beta-hydroxy amides 6 and 7 were treated with triphenylphosphonium anhydride trifluoromethane sulfonate (3), or the cyclic analogue 4, to generate 2-oxazolines 5 and 8 under mild conditions. The reaction was optimised by examining the number of equiv
Autor:
Peter Conrad Healy, Ian D. Jenkins, Wendy Anne Loughlin, Camille Marchal, Ann Almesaker, Maria Jenni Petersson
Publikováno v:
Tetrahedron. 63:1395-1401
Regioselective nucleophilic addition at C1 of anhydride 7 by a range of nucleophiles occurs to produce amide, ester and thioester derivatives 8–15 (60–99%). The increased electrophilic reactivity of the C1 carbonyl group of anhydride 7 is support
Publikováno v:
ChemInform. 44
Methods for the cyclodehydration of N-(aminoalkyl)benzamides are few and employ harsh reaction conditions. We have found that the easily prepared phosphonium anhydrides 1 (Hendrickson reagent) or 2 can be used for cyclodehydration of N-(aminoalkyl)be
Publikováno v:
ChemInform. 40
β-Hydroxy amides6 and 7 were treated with triphenylphosphonium anhydride trifluoromethane sulfonate (3), or the cyclic analogue 4, to generate 2-oxazolines 5 and 8 under mild conditions. The reaction was optimised by examining the number of equivale
Publikováno v:
ChemInform. 40
Bis-phosphine oxides can be selectively reduced to bis-phosphine monoxides under exceptionally mild conditions using triflic anhydride and a thiol.
Publikováno v:
The Journal of organic chemistry. 73(12)
The structure of a polymer-supported version of the Hendrickson "POP" reagent, prepared by the reaction of polymer-supported triphenylphosphine oxide 1 with triflic anhydride, is established as an equilibrium mixture of polymer-supported triphenylpho
Autor:
Gregory K. Pierens, Luke C. Henderson, Wendy Anne Loughlin, Peter Conrad Healy, Maria Jenni Petersson
Publikováno v:
Bioorganicmedicinal chemistry. 16(11)
The lipophilicity, permeability, solubility, polar surface area and ‘rule-of-five’ properties were assessed, using QikProp v2.5 (Schrodinger, Inc.) and ALOGPS 2.1 calculations, for 25 previous termHyphoderminnext term derivatives. These compounds
Autor:
Camille Marchal, Ann Almesaaker, Peter Conrad Healy, Ian D. Jenkins, Maria Jenni Petersson, Wendy Anne Loughlin
Publikováno v:
ChemInform. 38
Publikováno v:
Chemical Communications. :4493
Bis-phosphine oxides can be selectively reduced to bis-phosphine monoxides under exceptionally mild conditions using triflic anhydride and a thiol.