The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol

Autor: Laurence Lins, Magali Deleu, Maria Janikowska-Sagan, Donatienne Tyteca, Emily J. S. Claereboudt, Sandrine L. Verstraeten, Marie-Paule Mingeot-Leclercq

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific reports, Vol. 9, no.1, p. 7285 [1-14] (2019)

The membrane activity of some saponins, such as digitonin or alpha-hederin, is usually attributed to their interaction with membrane cholesterol (Chol). This contrasts with our recent publication showing that Chol, contrary to sphingomyelin (SM), can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d88bc77e2d250402ce66865280df6d
http://link.springer.com/article/10.1038/s41598-019-43674-w

Crucial role of the hydroxyl group orientation in Langmuir monolayers organization : the case of 7-hydroxycholesterol epimers

Autor: Maria Janikowska-Sagan, J.L. Rodríguez, José Miñones Conde, Anita Wnętrzak, Anna Chachaj-Brekiesz, Patrycja Dynarowicz-Latka

Oxysterols, which are products of cholesterol oxidation, are important biological molecules. For our investigations we have selected two epimers: 7α-hydroxycholesterol (7α-OH) and 7 β-hydroxycholesterol (7β-OH). Both molecules have been found to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8680d96848a3032ac15fa58f7a9458d2
https://ruj.uj.edu.pl/xmlui/handle/item/67402