Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Maria Jakobsen"'
Autor:
Annemarie Brüel, Bent Deleuran, Jørgen Kjems, Chuanxu Yang, Frederik Dagnæs-Hansen, Ping Song, Maria Jakobsen, Jesper Skovhus Thomsen
Publikováno v:
Mol Ther
Song, P, Yang, C, Thomsen, J S, Dagnaes-Hansen, F, Jakobsen, M, Bruel, A, Deleuran, B & Kjems, J 2019, ' Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model ', Molecular Therapy, vol. 27, no. 8, pp. 1424-1435 . https://doi.org/10.1016/j.ymthe.2019.05.002
Song, P, Yang, C, Thomsen, J S, Dagnaes-Hansen, F, Jakobsen, M, Bruel, A, Deleuran, B & Kjems, J 2019, ' Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model ', Molecular Therapy, vol. 27, no. 8, pp. 1424-1435 . https://doi.org/10.1016/j.ymthe.2019.05.002
Interleukin-1 beta (IL-1 beta) plays a central role in the induction of rheumatoid arthritis (RA). In the present study, we demonstrated that lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1 beta (siIL-1 beta)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4814fac3f5195e206ff74cbf1849bb0c
https://doi.org/10.1016/j.ymthe.2019.05.002
https://doi.org/10.1016/j.ymthe.2019.05.002
Autor:
Niels Chr. Nielsen, Mads Sloth Vinding, Frederik Dagnæs-Hansen, Maria Jakobsen, Hieu Vu-Quang, Ping Song, Jørgen Kjems
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Vu-Quang, H, Vinding, M S, Jakobsen, M, Song, P, Dagnaes-Hansen, F, Nielsen, N C & Kjems, J 2019, ' Imaging rheumatoid arthritis in mice using combined near infrared and 19 F magnetic resonance modalities ', Scientific Reports, vol. 9, 14314 . https://doi.org/10.1038/s41598-019-50043-0
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Vu-Quang, H, Vinding, M S, Jakobsen, M, Song, P, Dagnaes-Hansen, F, Nielsen, N C & Kjems, J 2019, ' Imaging rheumatoid arthritis in mice using combined near infrared and 19 F magnetic resonance modalities ', Scientific Reports, vol. 9, 14314 . https://doi.org/10.1038/s41598-019-50043-0
Rheumatoid arthritis (RA) is an autoimmune disease that causes pain and tissue destruction in people worldwide. An accurate diagnosis is paramount in order to develop an effective treatment plan. This study demonstrates that combining near infrared (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a209d7623ff07a591de97ede5aec8c
http://europepmc.org/articles/PMC6778085
http://europepmc.org/articles/PMC6778085
Publikováno v:
Yang, C, Gao, S, Song, P, Dagnæs-Hansen, F, Jakobsen, M V & Kjems, J 2018, ' Theranostic Niosomes for Efficient siRNA/microRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells ', A C S Applied Materials and Interfaces, vol. 10, no. 23, pp. 19494–19503 . https://doi.org/10.1021/acsami.8b05513
RNA interference-mediated gene regulation in stem cells offers great potential in regenerative medicine. In this study, we developed a theranostic platform for efficient delivery of small RNAs [small interfering RNA (siRNA)/microRNA (miRNA)] to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae23a3891cd0df1fa27f51aa7541edf2
https://pubmed.ncbi.nlm.nih.gov/29767944
https://pubmed.ncbi.nlm.nih.gov/29767944
Publikováno v:
Yang, C, Gao, S, Dagnæs-Hansen, F, Jakobsen, M & Kjems, J 2017, ' Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo ', A C S Applied Materials and Interfaces, vol. 9, no. 14, pp. 12203-12216 . https://doi.org/10.1021/acsami.6b16556
PEGylation of cationic polyplexes is a promising approach to enhance the stability and reduce unspecific interaction with biological components. Herein, we systematically investigate the impact of PEGylation on physical and biological properties of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8047a30dd5bdd2e8227d7acc40081a4c
https://pure.au.dk/portal/da/publications/impact-of-peg-chain-length-on-the-physical-properties-and-bioactivity-of-pegylated-chitosansirna-nanoparticles-in-vitro-and-in-vivo(5cf87a1f-6205-4eb7-a417-b5bdb8edd59e).html
https://pure.au.dk/portal/da/publications/impact-of-peg-chain-length-on-the-physical-properties-and-bioactivity-of-pegylated-chitosansirna-nanoparticles-in-vitro-and-in-vivo(5cf87a1f-6205-4eb7-a417-b5bdb8edd59e).html
Autor:
Maria Jakobsen, Jacob Giehm Mikkelsen, Brian Moldt, Søren Kamp, Karin Stenderup, Tomas Norman Dam, Cecilia Rosada, Thomas G. Jensen
Publikováno v:
Jakobsen, M, Stenderup, K, Rosada, C, Moldt, B, Kamp, S, Dam, T N, Jensen, T G & Mikkelsen, J G 2009, ' Amelioration of Psoriasis by Anti-TNF-alpha RNAi in the Xenograft Transplantation Model ', Molecular Therapy . https://doi.org/10.1038/mt.2009.141
Udgivelsesdato: 2009-Jun-30 Tumor necrosis factor-alpha (TNF-alpha) is upregulated in psoriatic skin and represents a prominent target in psoriasis treatment. The level of TNF-alpha-encoding mRNA, however, is not increased in psoriatic skin, and it r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42292534b4035962f75c0fb89d56d55
Publikováno v:
Christensen, R, Alhonen, L, Wahlfors, J, Jacobsen, M & Jensen, T G 2005, ' Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin. ', Experimental Dermatology, vol. 14, no. 7, pp. 535-542 .
Christensen, R, Alhonen, L, Wahlfors, J, Jakobsen, M & Jensen, T G 2005, ' Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin ' Experimental Dermatology Online, vol. 14, no. 7, pp. 535-42 . https://doi.org/10.1111/j.0906-6705.2005.00326.x
Christensen, R, Alhonen, L, Wahlfors, J, Jakobsen, M & Jensen, T G 2005, ' Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin ' Experimental Dermatology Online, vol. 14, no. 7, pp. 535-42 . https://doi.org/10.1111/j.0906-6705.2005.00326.x
Phenylketonuria (PKU) is a metabolic disease causing increased levels of phenylalanine in blood and body fluids. Circulating phenylalanine is normally cleared by phenylalanine hydroxylase (PAH) expressed in the liver. The aim of this study is to expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4af1d046763f105456eb8bddf48ae97
https://doi.org/10.1111/j.0906-6705.2005.00326.x
https://doi.org/10.1111/j.0906-6705.2005.00326.x
Autor:
Thomas G. Jensen, Alexander A. L. Jorge, Paolo Bartolini, Lars Aagaard, Eliza Higuti, Hanne Gissel, Frederick Dagnaes-Hansen, Cibele N. Peroni, Nélio A. J. Oliveira, Claudia R. Cecchi, Maria Jakobsen, Eliana R. Lima
Publikováno v:
Cecchi, C R, Higuti, E, Oliveira, N A J, Lima, E R, Jakobsen, M, Dagnaes-Hansen, F, Gissel, H, Aagaard, L, Jensen, T G, Jorge, A A L, Bartolini, P & Peroni, C N 2014, ' A novel homologous model for gene therapy of dwarfism by non-viral transfer of the mouse growth hormone gene into immunocompetent dwarf mice ', Current Gene Therapy, vol. 14, no. 1, pp. 44-51 .
The possibilities for non-viral GH gene therapy are studied in immunocompetent dwarf mice (lit/lit). As expression vector we used a plasmid previously employed in immunodeficient dwarf mice (pUBI-hGH-gDNA) by replacing the human GH gene with the geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecfaeaa718642e59b1e0a386908ab7c
https://pure.au.dk/portal/da/publications/a-novel-homologous-model-for-gene-therapy-of-dwarfism-by-nonviral-transfer-of-the-mouse-growth-hormone-gene-into-immunocompetent-dwarf-mice(f38f2fb6-0e77-4102-97ab-042e6738ccc9).html
https://pure.au.dk/portal/da/publications/a-novel-homologous-model-for-gene-therapy-of-dwarfism-by-nonviral-transfer-of-the-mouse-growth-hormone-gene-into-immunocompetent-dwarf-mice(f38f2fb6-0e77-4102-97ab-042e6738ccc9).html
Autor:
Merry Jo Oursler, Christina Sveigaard, Trine Overgaard, Henriette Misander, Niels T. Foged, Bente Therkildsen, Maria Jakobsen, Bent Winding
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 126:631-640
Purpose: The purpose of this study was to elucidate the potential of human breast cancer cells (BCC) to induce matrix degradation and neo-vascularization, essential for continued tumor growth, in osteolytic lesions. Methods: BCC were inoculated into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ac4659ddcde2ff29a5751147f543e
https://doi.org/10.1007/pl00008475
https://doi.org/10.1007/pl00008475
Autor:
Rune Thomsen, Maria Jakobsen, Thomas J. Corydon, Thomas G. Jensen, Christina Bøg Pedersen, Niels Gregersen, Jens Michael Hertz, Olof Joakim Pettersson, Jan Larsen
Publikováno v:
BMC Research Notes, Vol 4, Iss 1, p 490 (2011)
BMC Research Notes
Larsen, J, Pettersson, O J, Jakobsen, M, Thomsen, R, Pedersen, C B, Hertz, J M, Gregersen, N, Corydon, T J & Jensen, T G 2011, ' Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules ', BMC Research Notes, vol. 4, pp. 490 . https://doi.org/10.1186/1756-0500-4-490
BMC Research Notes
Larsen, J, Pettersson, O J, Jakobsen, M, Thomsen, R, Pedersen, C B, Hertz, J M, Gregersen, N, Corydon, T J & Jensen, T G 2011, ' Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules ', BMC Research Notes, vol. 4, pp. 490 . https://doi.org/10.1186/1756-0500-4-490
Background Myotonic dystrophy type 1 (DM1) is the most common muscle dystrophy in adults. The disease is caused by a triplet expansion in the 3'end of the myotonic dystrophy protein kinase (DMPK) gene. In order to develop a human cell model for inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac9c6e10afcc505bb2194ebe7105b07
http://www.biomedcentral.com/1756-0500/4/490
http://www.biomedcentral.com/1756-0500/4/490
Autor:
Rasmus O. Bak, Line Petersen, Brian Moldt, Cecilia Rosada, Thomas G. Jensen, Maria Jakobsen, Frederik Dagnæs-Hansen, Søren Kamp, Karin Stenderup, Jacob Giehm Mikkelsen, Tomas Norman Dam
Publikováno v:
Bak, R O, Stenderup, K, Rosada, C, Petersen, L B, Moldt, B, Dagnæs-Hansen, F, Jakobsen, M, Kamp, S, Jensen, T G, Dam, T N & Mikkelsen, J G 2011, ' Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin ', B M C Dermatology, vol. 11, no. 1, pp. 5 . https://doi.org/10.1186/1471-5945-11-5
BMC Dermatology, Vol 11, Iss 1, p 5 (2011)
Publons
BMC Dermatology
BMC Dermatology, Vol 11, Iss 1, p 5 (2011)
Publons
BMC Dermatology
Background Psoriasis is a chronic inflammatory skin disorder that shows as erythematous and scaly lesions. The pathogenesis of psoriasis is driven by a dysregulation of the immune system which leads to an altered cytokine production. Proinflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9ffd29e790075c93d373d6d3d6bd04
https://doi.org/10.1186/1471-5945-11-5
https://doi.org/10.1186/1471-5945-11-5