Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria J. van Maanen"'
Autor:
Hilde Rosing, Mariët Ouwehand, Suzanne V. Frankfort, Maria J. van Maanen, Linda R. Tulner, Jos H. Beijnen
Publikováno v:
Rapid Communications in Mass Spectrometry. 20:3330-3336
A sensitive and specific high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the determination of rivastigmine and its major metabolite NAP 226-90 is presented. A 100 microL plasma aliquot was spiked with a structur
Autor:
Hilde Rosing, Natalie M. G. M. Appels, Jos H. Beijnen, Jan H.M. Schellens, Maria J. van Maanen
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:2187-2192
Lonafarnib is a novel anticancer drug that inhibits farnesyl transferase. To assess its pharmacokinetic properties, we developed a sensitive and quantitative assay using liquid chromatography coupled with tandem mass spectrometry for the determinatio
Autor:
J. Mirjam A. Damen, Karen Doesburg Smits, Maria J. van Maanen, Jos H. Beijnen, Albert J. R. Heck
Publikováno v:
International Journal of Pharmaceutics. 200:187-194
The degradation of N,N',N"-triethylenethiophosphoramide (thioTEPA) and its metabolites N,N',N"-triethylenephosphoramide (TEPA), N, N'-diethylene,N"-2-chloroethylphosphoramide (monochloroTEPA) and thioTEPA-mercapturate in plasma and urine has been inv
Autor:
Hilde Rosing, Carola W. N. Damen, Matthijs M. Tibben, Jurjen S. Lagas, Maria J. van Maanen, Jan H.M. Schellens, Alfred H. Schinkel, Jos H. Beijnen
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 868(1-2)
A sensitive, specific and fast high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) assay for the determination of vinorelbine in mouse and human plasma is presented. A 200 microL aliquot was extracted with solid-phase extract
Publikováno v:
Anti-cancer drugs. 12(6)
The urinary excretion of N,N',N"-triethylenethiophosphoramide (thioTEPA), and its metabolites N,N',N"-triethylenephosphoramide (TEPA), N,N'-diethylene,N"-2-chloroethylphosphoramide (monochloroTEPA) and thioTEPA--mercapturate was determined in patient