Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Maria J. Solares"'
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTLow molecular weight proteins and protein assemblies can now be investigated using cryo-electron microscopy (EM) as a complement to traditional structural biology techniques. It is important, however, to not lose sight of the dynamic informat
Externí odkaz:
https://doaj.org/article/cefba15d3c474cc494a294cfb295b6f1
Autor:
Deborah F. Kelly, G M Jonaid, Liam Kaylor, Maria J. Solares, Samantha Berry, Liza-Anastasia DiCecco, William Dearnaley, Michael Casasanta
Publikováno v:
Micromachines, Vol 14, Iss 10, p 1869 (2023)
As small protein assemblies and even small proteins are becoming more amenable to cryo-Electron Microscopy (EM) structural studies, it is important to consider the complementary dynamic information present in the data. Current computational strategie
Externí odkaz:
https://doaj.org/article/97585190ef774b448276068177eb9674
Autor:
Maria J. Solares, Deborah F. Kelly
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15267 (2022)
Mutations in tumor suppressor genes often lead to cancerous phenotypes. Current treatments leverage signaling pathways that are often compromised by disease-derived deficiencies in tumor suppressors. P53 falls into this category as genetic mutations
Externí odkaz:
https://doaj.org/article/26feec1eb99844529d035a7559424d06
Autor:
Ashley A. Burke, Elizabeth S. Severson, Shreya Mool, Maria J. Solares Bucaro, Frederick T. Greenaway, Charles E. Jakobsche
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 496-503 (2017)
Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and blocking its activity has been shown to limit the metastatic potential of various cancers. The
Externí odkaz:
https://doaj.org/article/59db6297f1eb46cb98f90a5bcdddc6d3
Autor:
Michael A Casasanta, G M Jonaid, Liam Kaylor, William Y Luqiu, Liza-Anastasia DiCecco, Maria J Solares, Samantha Berry, William J Dearnaley, Deborah F Kelly
Publikováno v:
Microscopy and Microanalysis. 29:649-657
The nucleocapsid (N) protein is an abundant component of SARS-CoV-2 and a key analyte for lateral-flow rapid antigen tests. Here, we present new structural insights for the SARS-CoV-2 N protein using cryo-electron microscopy (EM) and molecular modeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1730d05584bdc073b68e959d127b9b0e
https://doi.org/10.1093/micmic/ozac036
https://doi.org/10.1093/micmic/ozac036
Autor:
Maria J. Solares, Deborah F. Kelly
Publikováno v:
Microscopy Today. 30:10-17
Microscopy has evolved through centuries of desire to see the unseen world. Modern technologies have pushed the limits of what's possible, inspiring the field of structural biology. Coupled with advances in biochemistry, scientists can now study the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1f06ccf57a04db79b0f258bfeac3d2
https://doi.org/10.1017/s1551929522000426
https://doi.org/10.1017/s1551929522000426
Autor:
Deborah F. Kelly, Sarah M. McDonald Esstman, Kathryn Grandfield, Madeline J. Dressel-Dukes, Michael Spilman, William J. Dearnaley, Carol Bator, Jennifer L. Gray, Liam Kaylor, Maria J. Solares, G. M. Jonaid, Samantha Berry, Liza-Anastasia DiCecco
Publikováno v:
Journal of Visualized Experiments.
Interest in liquid-electron microscopy (liquid-EM) has skyrocketed in recent years as scientists can now observe real-time processes at the nanoscale. It is extremely desirable to pair high-resolution cryo-EM information with dynamic observations as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7027ecd44140f022036594cc113526e5
https://doi.org/10.3791/63856
https://doi.org/10.3791/63856
Autor:
Maria J. Solares, G. M. Jonaid, William Y. Luqiu, Samantha Berry, Janki Khadela, Yanping Liang, Madison C. Evans, Kevin J. Pridham, William J. Dearnaley, Zhi Sheng, Deborah F. Kelly
Publikováno v:
ChemBioChem. 23
Mutations in tumor suppressor genes, such as Tumor Protein 53 (TP53), are heavily implicated in aggressive cancers giving rise to gain- and loss-of-function phenotypes. While individual domains of the p53 protein have been studied extensively, struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2046a2926164f20c5d00205f4d39b534
https://doi.org/10.1002/cbic.202200310
https://doi.org/10.1002/cbic.202200310
Autor:
Liam Kaylor, William J. Dearnaley, Maria J. Solares, Michael A. Casasanta, Madeline J. Dukes, Jarad J. Wilson, Mariah L. Schroen, Deborah F. Kelly, William Y. Luqiu, G. M. Jonaid
Publikováno v:
Nanoscale
Interest in cryo-Electron Microscopy (EM) imaging has skyrocketed in recent years due to its pristine views of macromolecules and materials. As advances in instrumentation and computing algorithms spurred this progress, there is renewed focus to addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a34a7c269dc50ad4a0e3179ad32d24e
https://doi.org/10.1039/d1nr00388g
https://doi.org/10.1039/d1nr00388g
Publikováno v:
Microscopy and Microanalysis. 27:2092-2094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138ddf5a9d2d4b6a4b907354e26b0c08
https://doi.org/10.1017/s1431927621007558
https://doi.org/10.1017/s1431927621007558