Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Maria J. Sanchez-Quintero"'
Autor:
Carlos Lopez-Gomez, Henly Hewan, Carlos Sierra, Hasan O. Akman, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Saba Tadesse, Kurenai Tanji, Elisa E. Konofagou, Michio Hirano
Publikováno v:
EBioMedicine, Vol 46, Iss , Pp 356-367 (2019)
Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway. Deficiency of TK2 activity causes mitochondrial DNA (mtDNA) depletion, which in h
Externí odkaz:
https://doaj.org/article/d89965251f304cec933695d220f6d175
Autor:
Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Recent data suggest that glioblastomas (GBM) activate the c-MET signaling pathway and display increased levels in anti-apoptotic Bcl-2 family members. Therefore, targeting these two deregulated pathways for therapy might yield synergistic tr
Externí odkaz:
https://doaj.org/article/c7b64c32e50d4b209c3d47ac8b498b63
Autor:
Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-20 (2019)
Abstract Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with globa
Externí odkaz:
https://doaj.org/article/34407949ed7c4e12861f0104f22e7368
Autor:
Thomas G. Diacovo, Andrea Califano, Xi Chen, Charles Karan, Vadim Ten, Zoya Niatsetskaya, Ronald Realubit, Jianchung Chen, Brian J. Lannutti, Andrew Kung, Daniel Diolaiti, Maria J. Sanchez-Quintero, Yao Shen, Irina V. Lebedeva, Utpal P. Davé, Evgeni Efimenko
5 supplementary figures Supplementary figure legends 3 supplementary tables Supplementary methods Supplementary references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e0303f025cc6a1e2904afe9976d95f
https://doi.org/10.1158/1535-7163.22508469.v1
https://doi.org/10.1158/1535-7163.22508469.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
Figure S1. Crizotinib resistant cells reveal a reprogrammed tumor metabolism. Figure S2. Crizotinib modulates fatty acid metabolism and mitochondrial parameters. Figure S3. Tracing analysis reveals distinct modulation of metabolism by MET inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ca270b2531ae2a9908279f0411cd4
https://doi.org/10.1158/0008-5472.22423917.v1
https://doi.org/10.1158/0008-5472.22423917.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Purpose: Glioblastoma remains a challenge in oncology, in part due to tumor heterogeneity.Experimental Design: Patient-derived xenograft and stem-like glioblastoma cells were used as the primary model systems.Results: Based on a transcriptome and sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14156097234a9ce61d44092209fa71b7
https://doi.org/10.1158/1078-0432.c.6528969.v1
https://doi.org/10.1158/1078-0432.c.6528969.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455509f6f2fb3a456aacdb303efa1473
https://doi.org/10.1158/1078-0432.22475013
https://doi.org/10.1158/1078-0432.22475013
Autor:
Markus D. Siegelin, Joshua E. Allen, Varun V. Prabhu, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Trang T.T. Nguyen, Chang Shu, Elena Bianchetti, Yiru Zhang, Chiaki T. Ishida
Purpose: The goal of this study is to enhance the efficacy of imipridones, a novel class of AKT/ERK inhibitors that displayed limited therapeutic efficacy against glioblastoma (GBM).Experimental Design: Gene set enrichment, LC/MS, and extracellular f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a1bacae2ecb3e358c90ecca13396b5
https://doi.org/10.1158/1078-0432.c.6529275.v1
https://doi.org/10.1158/1078-0432.c.6529275.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6927c0d5296b85502a38feeb20f8211
https://doi.org/10.1158/0008-5472.c.6511608.v1
https://doi.org/10.1158/0008-5472.c.6511608.v1
Autor:
Markus D. Siegelin, Joshua E. Allen, Varun V. Prabhu, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Trang T.T. Nguyen, Chang Shu, Elena Bianchetti, Yiru Zhang, Chiaki T. Ishida
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a9bcbb49c9b971f9059198bda4d09
https://doi.org/10.1158/1078-0432.22476039
https://doi.org/10.1158/1078-0432.22476039