Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Maria J. Sanchez-Quintero"'
Autor:
Carlos Lopez-Gomez, Henly Hewan, Carlos Sierra, Hasan O. Akman, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Saba Tadesse, Kurenai Tanji, Elisa E. Konofagou, Michio Hirano
Publikováno v:
EBioMedicine, Vol 46, Iss , Pp 356-367 (2019)
Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway. Deficiency of TK2 activity causes mitochondrial DNA (mtDNA) depletion, which in h
Externí odkaz:
https://doaj.org/article/d89965251f304cec933695d220f6d175
Autor:
Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Recent data suggest that glioblastomas (GBM) activate the c-MET signaling pathway and display increased levels in anti-apoptotic Bcl-2 family members. Therefore, targeting these two deregulated pathways for therapy might yield synergistic tr
Externí odkaz:
https://doaj.org/article/c7b64c32e50d4b209c3d47ac8b498b63
Autor:
Thomas G. Diacovo, Andrea Califano, Xi Chen, Charles Karan, Vadim Ten, Zoya Niatsetskaya, Ronald Realubit, Jianchung Chen, Brian J. Lannutti, Andrew Kung, Daniel Diolaiti, Maria J. Sanchez-Quintero, Yao Shen, Irina V. Lebedeva, Utpal P. Davé, Evgeni Efimenko
5 supplementary figures Supplementary figure legends 3 supplementary tables Supplementary methods Supplementary references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e0303f025cc6a1e2904afe9976d95f
https://doi.org/10.1158/1535-7163.22508469.v1
https://doi.org/10.1158/1535-7163.22508469.v1
Autor:
Markus D. Siegelin, Joshua E. Allen, Varun V. Prabhu, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Trang T.T. Nguyen, Chang Shu, Elena Bianchetti, Yiru Zhang, Chiaki T. Ishida
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a9bcbb49c9b971f9059198bda4d09
https://doi.org/10.1158/1078-0432.22476039
https://doi.org/10.1158/1078-0432.22476039
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
Figure S1. Crizotinib resistant cells reveal a reprogrammed tumor metabolism. Figure S2. Crizotinib modulates fatty acid metabolism and mitochondrial parameters. Figure S3. Tracing analysis reveals distinct modulation of metabolism by MET inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ca270b2531ae2a9908279f0411cd4
https://doi.org/10.1158/0008-5472.22423917.v1
https://doi.org/10.1158/0008-5472.22423917.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Purpose: Glioblastoma remains a challenge in oncology, in part due to tumor heterogeneity.Experimental Design: Patient-derived xenograft and stem-like glioblastoma cells were used as the primary model systems.Results: Based on a transcriptome and sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14156097234a9ce61d44092209fa71b7
https://doi.org/10.1158/1078-0432.c.6528969.v1
https://doi.org/10.1158/1078-0432.c.6528969.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455509f6f2fb3a456aacdb303efa1473
https://doi.org/10.1158/1078-0432.22475013
https://doi.org/10.1158/1078-0432.22475013
Autor:
Markus D. Siegelin, Joshua E. Allen, Varun V. Prabhu, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Trang T.T. Nguyen, Chang Shu, Elena Bianchetti, Yiru Zhang, Chiaki T. Ishida
Purpose: The goal of this study is to enhance the efficacy of imipridones, a novel class of AKT/ERK inhibitors that displayed limited therapeutic efficacy against glioblastoma (GBM).Experimental Design: Gene set enrichment, LC/MS, and extracellular f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a1bacae2ecb3e358c90ecca13396b5
https://doi.org/10.1158/1078-0432.c.6529275.v1
https://doi.org/10.1158/1078-0432.c.6529275.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6927c0d5296b85502a38feeb20f8211
https://doi.org/10.1158/0008-5472.c.6511608.v1
https://doi.org/10.1158/0008-5472.c.6511608.v1
Autor:
Markus D. Siegelin, Joshua E. Allen, Varun V. Prabhu, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Trang T.T. Nguyen, Chang Shu, Elena Bianchetti, Yiru Zhang, Chiaki T. Ishida
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bee458ece33afb8bfc8c05e0978f484
https://doi.org/10.1158/1078-0432.22476045.v1
https://doi.org/10.1158/1078-0432.22476045.v1