Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria J. Ruiz Echevarría"'
Autor:
Joshua M. Corbin, Constantin Georgescu, Lin Wang, Jonathan D. Wren, Magdalena Bieniasz, Chao Xu, Adam S. Asch, Maria J. Ruiz Echevarría
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 257-272 (2023)
Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate cancer (PCa). However, acquired resistance to single agents targeting this pathway results in the development of lethal castration-resistant PCa. Combination therap
Externí odkaz:
https://doaj.org/article/41fabf28d4364d8697b56a2f8a9cd7e7
Autor:
Joshua M. Corbin, Constantin Georgescu, Jonathan D. Wren, Chao Xu, Adam S. Asch, Maria J. Ruiz-Echevarría
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 337-351 (2021)
Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate
Externí odkaz:
https://doaj.org/article/7f27fc30f9d341459f7710042befb4d8
Autor:
Constantin Georgescu, Joshua M. Corbin, Sandra Thibivilliers, Zachary D. Webb, Yan D. Zhao, Jan Koster, Kar-Ming Fung, Adam S. Asch, Jonathan D. Wren, Maria J. Ruiz-Echevarría
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background The clinical behavior of prostate cancer (PCa) is variable, and while the majority of cases remain indolent, 10% of patients progress to deadly forms of the disease. Current clinical predictors used at the time of diagnosis have l
Externí odkaz:
https://doaj.org/article/7e9ac0c4083a40768ff6d2ebaf0c452b
Autor:
Joshua M Corbin, Constantin Georgescu, Lin Wang, Jonathan D Wren, Magdalena Bieniasz, Chao Xu, Adam S Asch, Maria J Ruiz-Echevarría
Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate cancer (PCa). However, acquired resistance to single agents targeting this pathway results in the development of lethal castration resistant PCa. Combination therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4f049820e611d2cd46575a34b7f53a2
https://doi.org/10.1101/2022.09.29.510140
https://doi.org/10.1101/2022.09.29.510140
Autor:
Ryan F Overcash, Vesna A Chappell, Thomas Green, Christopher B Geyer, Adam S Asch, Maria J Ruiz-Echevarría
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55257 (2013)
The type I transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2), is expressed mainly in brain and prostate. Expression of TMEFF2 is deregulated in prostate cancer, suggesting a role in this disease, but the molecul
Externí odkaz:
https://doaj.org/article/b45bb9200217454485372865a9ae1a1d
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1208 (2016)
Cancer cell metabolism differs significantly from the metabolism of non-transformed cells. This altered metabolic reprogramming mediates changes in the uptake and use of nutrients that permit high rates of proliferation, growth, and survival. The and
Externí odkaz:
https://doaj.org/article/940e9aaaa0504687a38065f07d71bac1
Publikováno v:
The Prostate. 73(14)
The transmembrane protein with epidermal growth factor and two follistatin motifs, TMEFF2, has been implicated in prostate cancer but its role in this disease is unclear. We recently demonstrated that the tumor suppressor role of TMEFF2 correlates, i