Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Maria J. Guerra"'
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the
Externí odkaz:
https://doaj.org/article/dfa7d084a28d4264b26af20b3308215e
Autor:
Ana I. Rodriguez-Perez, Antonio Dominguez-Meijide, Jose L. Lanciego, Maria J. Guerra, Jose L. Labandeira-Garcia
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 209-219 (2013)
The mechanism by which estrogen protects dopaminergic neurons has not yet been clarified. It is not known if changes in RhoA/Rho kinase activity are involved in the enhanced vulnerability of dopaminergic neurons observed after estrogen depletion. The
Externí odkaz:
https://doaj.org/article/5706fe80763d4980bc5d923519da7230
Autor:
Begoña Villar-Cheda, Antonio Dominguez-Meijide, Belen Joglar, Ana I. Rodriguez-Perez, Maria J. Guerra, Jose L. Labandeira-Garcia
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 2, Pp 268-279 (2012)
It has recently been shown that the dopaminergic cell loss induced by neurotoxins is enhanced by brain angiotensin II (AII) via type 1 receptors (AT1). However, the mechanisms involved in the dopaminergic degeneration and the brain inflammatory effec
Externí odkaz:
https://doaj.org/article/c4eba1e33f98470092d4eb49d01832ea
Autor:
Ana I. Rodriguez-Perez, Jose L. Labandeira-Garcia, Pablo Garrido-Gil, Maria J. Guerra, Antonio Dominguez-Meijide
Publikováno v:
Molecular Neurobiology. 55:7297-7316
The exact mechanism of gut dysfunction in Parkinson's disease and, conversely, the role of gut pathology in brain dopaminergic degeneration are controversial. We investigated the effects of nigral lesions on the colonic neurotransmission, the effect
Autor:
Maria J. Guerra, Antonio Dominguez-Meijide, Jose L. Labandeira-Garcia, Rosario Moratalla, Pablo Garrido-Gil
Publikováno v:
Oncotarget
Gastrointestinal dysfunction is a common problem in the elderly. Aging-related changes in interactions between local dopaminergic and renin-angiotensin systems (RAS) have been observed in the brain, renal and vascular tissues. However, it is not know
Autor:
Pablo Garrido-Gil, Jose L. Labandeira-Garcia, Maria J. Guerra, Begoña Villar-Cheda, Antonio Dominguez-Meijide, Carmen Diaz-Ruiz
Publikováno v:
The Journals of Gerontology: Series A.
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the dopaminergic system. Both in vivo an
Autor:
Ana Borrajo, Maria J. Guerra, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Jannette Rodriguez-Pallares
Publikováno v:
Glia. 63:466-482
Previous studies have shown that the brain renin-angiotensin system may play a major role, via angiotensin type 1 (AT1) receptors, in the regulation of neuroinflammation, oxidative stress and progression of dopaminergic degeneration. Angiotensin-indu
Autor:
Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Maria J. Guerra, Antonio Dominguez-Meijide, Ana Borrajo, Begoña Villar-Cheda
Publikováno v:
The Neuroscientist. 21:616-629
The small GTP-binding protein Rho plays an important role in several cellular functions. RhoA, which is a member of the Rho family, initiates cellular processes that act on its direct downstream effector Rho-associated kinase (ROCK). ROCK inhibition
Autor:
Jose L. Labandeira-Garcia, Ana I. Rodríguez-Perez, Pablo Garrido-Gil, Jannette Rodriguez-Pallares, Jose L. Lanciego, Maria J. Guerra
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/alternatively activated (M2) phenotypes following environmental signals related to physiological conditions or brain lesions. An adequate transition from the
Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures
Autor:
Jose L. Labandeira-Garcia, Carmen Diaz-Ruiz, Antonio Dominguez-Meijide, Maria J. Guerra, Ana I. Rodriguez-Perez
Publikováno v:
Brain, behavior, and immunity. 62
Dopamine is an immunomodulatory molecule that acts on immune effector cells both in the CNS and peripheral tissues. However, the role of changes in dopamine levels in the neuroinflammatory response is controversial. The local/paracrine renin-angioten