Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Maria J Monte"'
Autor:
Jane I. Grove, Camilla Stephens, M. Isabel Lucena, Raúl J. Andrade, Sabine Weber, Alexander Gerbes, Einar S. Bjornsson, Guido Stirnimann, Ann K. Daly, Matthias Hackl, Kseniya Khamina-Kotisch, Jose J. G. Marin, Maria J. Monte, Sara A. Paciga, Melanie Lingaya, Shiva S. Forootan, Christopher E. P. Goldring, Oliver Poetz, Rudolf Lombaard, Alexandra Stege, Helgi K. Bjorrnsson, Mercedes Robles-Diaz, Dingzhou Li, Thi Dong Binh Tran, Shashi K. Ramaiah, Sophia L. Samodelov, Gerd A. Kullak-Ublick, Guruprasad P. Aithal, on behalf of the TransBioLine consortium
Publikováno v:
Diagnostic and Prognostic Research, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract A lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a challenge in clinical practice. The Innovative Medicines Initiative’s TransBioLine consor
Externí odkaz:
https://doaj.org/article/01c9031ea63844faa64609c76d355eda
Autor:
Elisa Herraez, Anabel Sanchez-Martin, Paula Sanchon-Sanchez, Jose J. G. Marin, Maria J. Monte
Publikováno v:
Exploration of Digestive Diseases, Vol 1, Iss 3, Pp 137-153 (2022)
Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or taurine. This process can
Externí odkaz:
https://doaj.org/article/78ee4e2407874baf9f69c8207b3d3c6f
Autor:
Marta Alonso-Peña, Ricardo Espinosa-Escudero, Heike M. Hermanns, Oscar Briz, Jose M. Herranz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Javier Juamperez, Matias Avila, Josepmaria Argemi, Ramon Bataller, Javier Crespo, Maria J. Monte, Andreas Geier, Elisa Herraez, Jose J. G. Marin
Publikováno v:
Cells, Vol 11, Iss 24, p 3983 (2022)
Bile acid (BA) synthesis from cholesterol by hepatocytes is inhibited by inflammatory cytokines. Whether liver inflammation also affects BA side chain shortening and conjugation was investigated. In human liver cell lines (IHH, HepG2, and HepaRG), ag
Externí odkaz:
https://doaj.org/article/afa68f19897a4a61904c36422a1bf94e
Autor:
Ricardo Espinosa-Escudero, Elisa Herraez, Anabel Sanchez-Martin, Paula Sanchon-Sanchez, Jose J. G. Marin, Maria J. Monte
Publikováno v:
Exploration of Digestive Diseases. :137-153
Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or taurine. This process can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9a9154633485ffe1808838893db0f3
https://doi.org/10.37349/edd.2022.00010
https://doi.org/10.37349/edd.2022.00010
Autor:
Ibone Labiano, Aloña Agirre-Lizaso, Paula Olaizola, Anne Echebarria, Maider Huici-Izagirre, Irene Olaizola, Aitor Esparza-Baquer, Omar Sharif, Elizabeth Hijona, Piotr Milkiewicz, Malgorzata Milkiewicz, Francisco González-Romero, Patricia Aspichueta, Maria J. Monte, Jose J.G. Marin, Mihael Vucur, Tom Luedde, Marco Marzioni, Derek A. Mann, Luis Bujanda, Pedro M. Rodrigues, Jesus M. Banales, Maria J. Perugorria
Publikováno v:
Journal of Hepatology
Backgroundand aims: inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central to cholestatic liver injury. The triggering receptor expressed on myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2c60dc6efe95c81adaffe32d01e643
https://doi.org/10.1016/j.jhep.2022.05.044
https://doi.org/10.1016/j.jhep.2022.05.044
Autor:
Rui E. Castro, Rocio I.R. Macias, Jose J.G. Marin, Javier González-Gallego, Maria J. Monte, André L. Simão, Jesús M. González-Santiago, Maria A. Serrano, José L. Mauriz, Isabel Martín-Arribas
Publikováno v:
Aging (Albany NY)
Aging involves progressive physiological and metabolic reprogramming to adapt to gradual deterioration of organs and functions. This includes mechanisms of defense against pre-malignant transformations. Thus, certain tumors are more prone to appear i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7091093337204279bce7f36d3e8c2f
https://doi.org/10.18632/aging.203620
https://doi.org/10.18632/aging.203620
Autor:
Sara Lumbreras, Ruben Hernandez-Alcoceba, Maria J. Monte, Manuela Gonzalez-Aparicio, Gloria González-Aseguinolaza, Iker Uriarte, Lucía Baila-Rueda, Matías A. Avila, Lucia Mora-Jimenez, Ana Ricobaraza, Ana Cenarro, Maria Bunuales, Jose J.G. Marin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 210-221 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholesta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00add440dc9e8ee330875959da7c8e73
http://www.sciencedirect.com/science/article/pii/S2329050121001194
http://www.sciencedirect.com/science/article/pii/S2329050121001194
Autor:
Tamera Barrett, Julie Cavanagh-Kyros, Francisco Javier Cubero, Fátima Sánchez-Cabo, Davide Seruggia, Roger J. Davis, Laura Esteban-Lafuente, Chaobo Chen, Elisa Manieri, Maria J. Monte, María Elena Rodríguez, Guadalupe Sabio, Luis Leiva-Vega, Cintia Folgueira, Manuel Gómez, Alejandro Rosell, Jose J.G. Marin, Alfonso Mora
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway. It is established that one consequence of JNK activation is the development of insulin resistance and hepatic steatosis through inhibition of the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36c05308b217385439184c80c9063c0
http://europepmc.org/articles/PMC7368313
http://europepmc.org/articles/PMC7368313
Publikováno v:
Hepatobiliary Surgery and Nutrition. 9:211-214
Although only 10–15% of liver cancers are cholangiocarcinomas (CCAs), which derive from the epithelial cells of the biliary tree, these cancers constitute a serious and growing health problem worldwide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08efb74cfb41bce54ffa2f11543eee93
https://doi.org/10.21037/hbsn.2019.10.11
https://doi.org/10.21037/hbsn.2019.10.11
Autor:
Jesper B. Andersen, María L. Martínez-Chantar, Matías A. Avila, Ruba Al-Abdulla, Laura Sanchez-Vicente, Colm J O'Rourke, Letizia Satriano, Rocio I.R. Macias, Maria J. Monte, Elisa Lozano, Sofía Del Carmen, Maitane Asensio, Jose J.G. Marin, Jesus M. Banales, Oscar Briz, Patricia Munoz-Garrido, Marta Alonso-Peña
Publikováno v:
Hepatology. 70:1246-1261
Although the multi-tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug. Among other mechanisms of chemoresistance, impaired uptake through human organic cation transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c745e2a1c2d845892285d5c5bb8dc85a
https://doi.org/10.1002/hep.30656
https://doi.org/10.1002/hep.30656