Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.

Autor: Ivy Y Choi, Olga N Karpus, Jason D Turner, Debbie Hardie, Jennifer L Marshall, Maria J H de Hair, Karen I Maijer, Paul P Tak, Karim Raza, Jörg Hamann, Christopher D Buckley, Danielle M Gerlag, Andrew Filer

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182751 (2017)

Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, ST expression of stromal markers in early arthritis in relationship to diagnosis and prognostic

Externí odkaz: https://doaj.org/article/890b055de3ca40f586d0a6584e8bd9e6

Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals.

Autor: Karen I Maijer, Elena Neumann, Ulf Müller-Ladner, Daniël A C A D Drop, Tamara H Ramwadhdoebe, Ivy Y K Choi, Daniëlle M Gerlag, Maria J H de Hair, Paul P Tak

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144932 (2015)

We have previously shown that overweight may increase the risk of developing rheumatoid arthritis (RA) in autoantibody positive individuals. Adipose tissue could contribute to the development of RA by production of various bioactive peptides. Therefo

Externí odkaz: https://doaj.org/article/1bf81916a31141378485f7d8dec2ce0e

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis

Autor: Monika Hansson, Paul P. Tak, Matthijs Janssen, M. Starmans-Kool, Niek de Vries, Aeilko H. Zwinderman, Man Wai Tang, M Safy, KI Maijer, Danielle M. Gerlag, Sander W. Tas, Maria J. H. de Hair, Astrid van Tubergen

Publikováno v: Annals of the Rheumatic Diseases, 78(2), 179-185. BMJ Publishing Group
Annals of the Rheumatic Diseases
Annals of the rheumatic diseases, 78(2), 179-185. BMJ Publishing Group

ObjectivesWe explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a32bf8225b7480af9e3d0e49ed3c04
https://cris.maastrichtuniversity.nl/en/publications/07230099-8c92-4121-a545-fdfb46bc8886

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

Autor: Athina Spiliopoulou, Paul M. McKeigue, Peter Orchard, Costantino Pitzalis, Suzanne M M Verstappen, John D. Isaacs, Richard M. Weinshilboum, Ronald F van Vollenhoven, Donna K. Arnett, Leonid Padyukov, John C. Taylor, Jackie L Nam, Jonathan Massey, Anne Barton, Jianmei Wang, Heather J. Cordell, Jennifer H. Barrett, Stella Aslibekyan, Ian C. Scott, Paul P. Tak, Marco Colombo, Iain B. McInnes, Borbala Mifsud, Darren Plant, Michael R. Barnes, Paul Emery, Michael D Morgan, Duncan Porter, Sarah Twigg, Jane E. Freeston, Michiaki Kubo, Tim Bongartz, Felix Agakov, Andrew P. Cope, Ann W. Morgan, Maria J. H. de Hair, Jenna L. Strathdee, S. Louis Bridges, Taisei Mushiroda

Publikováno v: Taylor, J C, Bongartz, T, Massey, J, Mifsud, B, Spiliopoulou, A, Scott, I C, Wang, J, Morgan, M, Plant, D, Colombo, M, Orchard, P, Twigg, S, McInnes, I B, Porter, D, Freeston, J, Nam, J L, Cordell, H J, Issacs, J D, Strathdee, J L, Arnett, D, De Hair, M J H, Tak, P P, Aslibekyan, S, van Vollenhoven, R F, Padyukov, L, Bridges, S L, Pitzalis, C, Cope, A P, Verstappen, S, Emery, P, Barnes, M R, Agakov, F, McKeigue, P M, Mushiroda, T, Kubo, M, Weinshilboum, R M, Barton, A, Morgan, A W & Barrett, J H 2018, ' Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients ', Pharmacogenomics Journal . https://doi.org/10.1038/s41397-018-0025-5
2018, ' Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients ', Pharmacogenomics Journal . https://doi.org/10.1038/s41397-018-0025-5

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869682497c599f955a81cdf275697869
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046847176&origin=inward

Unmet Needs in Systemic Sclerosis Understanding and Treatment : the Knowledge Gaps from a Scientist’s, Clinician’s, and Patient’s Perspective

Autor: Petra Mosterman, Marta Cossu, Maria J. H. de Hair, Lorenzo Beretta, Timothy R D J Radstake

Publikováno v: Clinical Reviews in Allergy & Immunology, 55(3), 312–331. Humana Press
Clinical Reviews in Allergy & Immunology

Systemic sclerosis (SSc) is a highly heterogeneous disease caused by a complex molecular circuitry. For decades, clinical and molecular research focused on understanding the primary process of fibrosis. More recently, the inflammatory, immunological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f9c53b67f910a371bc4fbc077b61b3
https://dspace.library.uu.nl/handle/1874/376958