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Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Autor: Marina Serrano-Maciá 1 , Jorge Simón 1,2 , Maria J. González-Rellan 3,4 , Mikel Azkargorta 5 , Naroa Goikoetxea-Usandizaga 1 , Fernando Lopitz-Otsoa 6 , Diego Saenz De Urturi 7 , Rubén Rodríguez-Agudo 1 , Sofia Lachiondo-Ortega 1 , Maria Mercado-Gomez 1 , Virginia Gutiérrez de Juan 6 , Maider Bizkarguenaga 6 , David Fernández-Ramos 2,6 , Xabier Buque 7,8 , Guido A. Baselli 9,10, Luca V.C. Valenti 9,10, Paula Iruzubieta 11,12, Javier Crespo 11,12, Erica Villa 13, Jesus M. Banales 7,14, Matias A. Avila 7,15, Jose J.G. Marin 7,16, Patricia Aspichueta 6,8 , James Sutherland 17, Rosa Barrio 17, Ugo Mayor 18,19, Félix Elortza 5 , Dimitris P. Xirodimas 20, Rubén Nogueiras 3,4 , Teresa C. Delgado 1,**, María Luz Martínez-Chantar 1,2

Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adbe4028a758612be064e7fa1755020

Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period

Autor: Jesús Tornero, Alba Erra, Santos Castañeda, Carolina Pérez-García, Raimon Sanmartí, Sara Marsal, Ingrid Moller, Esperanza Naredo, Miguel A González-Gay, Celia Erausquin, Ivan Castellví, Javier Llorca, Alejandro Muñoz, María Galindo, Enrique Raya, Lydia Abasolo, Gema Bonilla, Alfonso Corrales, Inmaculada Ureña, Carlos Rodríguez-Lozano, Carlos González-Juanatey, Cristina Fernandez Carballido, Francisco J López-Longo, Miguel Ángel González-Gay, Eduardo Collantes, José A Miranda-Filloy, Sagrario Bustabad, Indalecio Monteagudo, Jose A Piqueras, Tatiana Cobo, Joan Maymó, Carmen Barbadillo, Soledad Ojeda, Jaime Calvo Alen, Antonio Fernandez Nebro, Isabel Rodríguez, Pilar Font, Martina Steiner, Eugenio Chamizo Carmona, Beatriz González Álvarez, Santiago Munoz, Joan M Nolla, Fernando Sánchez-Alonso, Julio Sanchez, Raul Menor Almagro, Ana Pérez Gómez, Monica Ibañez, Elena Heras-Recuero, Trinidad Pérez Sandoval, Miren Uriarte-Ecenarro, Angela Pecondón, Hye Sang Park, Jessica Polo y La Borda, Zulema Plaza, Carmen García Gómez, Ivan Ferraz-Amaro, Jesús Tomás Sanchez-Costa, Olga Carmen Sánchez-González, Ana Isabel Turrión-Nieves, Ana Perez-Alcalá, José L FernándezSueiro, José A Pinto-Tasende, Eugenia Gonzálezde Rábago, María J González-Fernández, Ramón Huguet Codina, Beatriz Yoldi, Mercedes Ramentol, Gabriela Ávila, Cayetano Alegre, Fernando Gamero, José García Torón, María P Moreno-Gil, Antonio Juan-Mas, Pilar Espiño, Inmaculada Ros, Horacio Berman, Oscar Fontseré Patón, Benjamín Fernández Gutiérrez, José M Pina-Salvador, María D Fábregas, Montserrat Romera, Jesús A García-Vadillo, Rosario García de Vicuña, María A Belmonte, María V Irigoyen, Olga Martínez González, Rebeca Belmonte Gómez, Pastora Granados Bautista, Azucena Hernández Sanz, José Santos Rey, Carmen O Sánchez-González, Javier Bachiller, Antonio Zea, Francisco J Manero, Chesús Beltrán Audera, Marta Medrano, Jesús Babío Herráez, Javier del Pino, Ruth López González, María Enriqueta Peiró, José M Senabre, José C Rosas, Isabel Rotés, Estefanía Moreno, Javier Calvo, Amalia Rueda, Pilar Morales, Ana Nieto, Ana Ruibal Escribano, Sergio Ros Expósito, Ginés Sánchez Nievas, Enrique Júdez Navarro, Manuela Sianes Fernández, Silvia Martínez Pardo, Manel Pujol, Alberto Cantabrana, Esmeralda Delgado, Sergio Rodríguez Montero, Javier Rivera Redondo, Teresa González Hernández, Francisco J González-Polo, José M Moreno, Emilio Giner Serret, Laura Cebrián Méndez, María Teresa Navío, Teresa Pedraz Penalva, Encarnación Pagán, Pablo Mesadel Castillo, Ana Cruz, Ana Turrión, Desireé Ruíz, Antonio López Meseguer, Manuel J Moreno, Luis F Linares, Mercedes Morcillo, María L González-Gómez, José M Aramburu, Natalia A Rivera, Olaia Fernández Berrizbeitia, Manel Riera, Yolanda María León, Miriam Amirall, Jordi Fiter, Julia Fernández Melón, Luis Espadaler, Joaquín Belzunegui, Inmaculada Bañegil, César Díaz, Ramón Valls, María Bonet, Eva Revuelta Evrard, Javier R Godo, José A González-Fernández

Publikováno v: RMD Open, Vol 10, Iss 2 (2024)

Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in Rh

Externí odkaz: https://doaj.org/article/24b10d2acb8442f4903aa568a7fb12ad

The changing structure of households and families, and its impact on health in Spain

Autor: Maria J. González Gonzaléz

Publikováno v: Finisterra-Revista Portuguesa de Geografia, Vol XLV, Iss 89, Pp 9-25 (2010)

This paper analyses some of the changes that have affected thefamily as an institution in Spain, using data from the 2001 census as a reference. Nowadays, there is a growing interest in new developing family structures, since this is another factor t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::a4063eaae68a7fcfbb16250968922821
http://www.ceg.ul.pt/finisterra/numeros/2010-89/89_01.pdf