Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A

Autor: T. Eteläinen, Reinis Svarcbahs, Maria Jäntti, V. Kulmala, Timo T. Myöhänen

Publikováno v: Free Radical Biology and Medicine. 169:14-23

Oxidative stress (OS) is a common toxic feature in various neurodegenerative diseases. Therefore, reducing OS could provide a potential approach to achieve neuroprotection. Prolyl oligopeptidase (PREP) is a serine protease that is linked to neurodege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f684aeda5e13723e48a3bb0e54b2b8da
https://doi.org/10.1016/j.freeradbiomed.2021.04.001

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Autor: Reinis Svarcbahs, Ulrika Julku, Timo T. Myöhänen, Maria Jäntti

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1777, p 1777 (2021)

Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein (aSyn) and induces its aggregation. PREP inhibitors have been shown to have beneficial effects in Parkinson’s disease models by enhancing the clearance of aSyn aggregat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c98ea1273b9c11b5dc86c21385f739

Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells

Autor: Anna Erlandsson, Hengjing Cui, Jyrki P. Kukkonen, Maiju K. Rinne, Jinar Rostami, Anna Falk, Maria Jäntti, Timo T. Myöhänen

Publikováno v: Biomedicine & Pharmacotherapy, Vol 131, Iss, Pp 110788-(2020)

Corrigendum: Biomedicine & Pharmacotherapy 133 (2021) 111019 WOS:000604603600003 Growing evidence emphasizes insufficient clearance of pathological alpha-synuclein (alpha SYN) aggregates in the progression of Parkinson's disease (PD). Consequently, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3140acb85cb807c376bb09f275958643
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425463

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Autor: Lauri Urvas, Tommi Kilpeläinen, Saara Kivioja, Ulrika Julku, Susanna Norrbacka, Maria Jäntti, Timo T. Myöhänen, Reinis Svarcbahs

Publikováno v: Svarcbahs, R, Jäntti, M, Kilpeläinen, T, Julku, U H, Urvas, L, Kivioja, S, Norrbacka, S & Myöhänen, T T 2020, ' Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A ', Pharmacological Research, vol. 151, 104558, pp. 104558 . https://doi.org/10.1016/j.phrs.2019.104558

Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurode-generative diseases for decades but its physiological function has remained unclear. We have previously found that PREP negatively regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02116a574f6e6ee7f58bad029131f48d
https://cris.vtt.fi/en/publications/139d5c98-290a-4315-8f91-f06457342666

Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

Autor: Maria Jäntti, Virpi Talman, Raimo K. Tuominen, Kaisa M. A. Paldanius, Teemu Natunen, Mikko Hiltunen, Petra Mäkinen, J.C. Wu, Timo Sarajärvi, Ilari Tarvainen

Publikováno v: Neuropharmacology. 141

Abnormal protein kinase C (PKC) function contributes to many pathophysiological processes relevant for Alzheimer's disease (AD), such as amyloid precursor protein (APP) processing. Phorbol esters and other PKC activators have been demonstrated to enh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb8384635c5a49c18fa4a5810bc90b8
https://pubmed.ncbi.nlm.nih.gov/30138694