Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria J, Saraiva"'
Autor:
Aubin Michalon, Andreas Hagenbuch, Christian Huy, Evita Varela, Benoit Combaluzier, Thibaud Damy, Ole B. Suhr, Maria J. Saraiva, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Analyzing memory B cell repertoires of the healthy elderly enabled Michalon et al. to develop a recombinant human antibody selective for transthyretin amyloid. This antibody removes cardiac amyloid through recruitment of phagocytic immune cells.
Externí odkaz:
https://doaj.org/article/0bd15e092d1f47498ea907338e89a448
Autor:
A. C. Teixeira, Maria J. Saraiva
Publikováno v:
Amyloid. 30:74-80
Biochemical characterisation of transthyretin variant TTR Y78F showed that this variant adopts a tetrameric conformation as normal TTR but exhibits some of the characteristics of an intermediate structure in the fibrillogenesis pathway. It was hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcecaa22be9ce0ca4b5054db42dbcf8f
https://doi.org/10.1080/13506129.2022.2122034
https://doi.org/10.1080/13506129.2022.2122034
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44992 (2012)
BACKGROUND: Defects in protein folding may lead to severe degenerative diseases characterized by the appearance of amyloid fibril deposits. Cytotoxicity in amyloidoses has been linked to poration of the cell membrane that may involve interactions wit
Externí odkaz:
https://doaj.org/article/cb48f66acfdd4148aba8ba37f096c1b7
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2899 (2008)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of amyloid beta-peptide (A-Beta) in the brain. Transthyretin (TTR) is a tetrameric protein of about 55 kDa mainly produced in the liver and choroid plexus of the
Externí odkaz:
https://doaj.org/article/5f1a82ac271040a8afc79957056f6af4
Autor:
Nelson Abrantes, Joana Luísa Pereira, Isabel Campos, Jan Jacob Keizer, Maria J. Saraiva, Fernando Gonçalves, João Puga, Ana Ré
Publikováno v:
CIÊNCIAVITAE
Mediterranean forests are highly susceptible to wildfires, which can cause several impacts not only within burnt areas but also on downstream aquatic ecosystems. The ashes’ washout from burnt areas by surface runoff can be a diffuse source of toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd55923b1a3e979007e51226ec445dd2
https://pubmed.ncbi.nlm.nih.gov/32126411
https://pubmed.ncbi.nlm.nih.gov/32126411
Autor:
Sílvia M. Rocha, Carlos Fonseca, António S. Barros, Ângelo C. Salvador, Tony Fernandes, Maria J. Saraiva, Joaquim P. Ferreira
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
In the last years, new approaches use scats analysis in ecological studies, like gas chromatographic techniques, has been developed. The aim of this study is to use VOCs (volatile organic compounds) released from scats to distinguish three mammal spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d154b79a7d73bebdc5d7bf6958047863
https://doi.org/10.1016/j.bse.2014.02.025
https://doi.org/10.1016/j.bse.2014.02.025
Publikováno v:
Journal of molecular recognition : JMR. 30(3)
Toxicity in amyloidogenic protein misfolding disorders is thought to involve intermediate states of aggregation associated with the formation of amyloid fibrils. Despite their relevance, the heterogeneity and transience of these oligomers have placed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11acda4082075b416c1c90ea2f03122c
https://pubmed.ncbi.nlm.nih.gov/27808434
https://pubmed.ncbi.nlm.nih.gov/27808434
Autor:
Ana, Martinho, Isabel, Gonçalves, Isabel, Cardoso, Maria R, Almeida, Telma, Quintela, Maria J, Saraiva, Cecília R A, Santos
Publikováno v:
The FEBS journal. 277(16)
Transthyretin (TTR), an amyloid-beta (Abeta) scavenger protein, and metallothioneins 2 and 3 (MT2 and MT3), low molecular weight metal-binding proteins, have recognized impacts in Abeta metabolism. Because TTR binds MT2, an ubiquitous isoform of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a717d5bf6bb4ef03c2b76d6f151bb1ae
https://pubmed.ncbi.nlm.nih.gov/20646067
https://pubmed.ncbi.nlm.nih.gov/20646067
Publikováno v:
Journal of neurochemistry. 103(2)
Mutations in transthyretin (TTR) are associated with familial amyloid polyneuropathy, a neurodegenerative disorder characterized by TTR deposition in the PNS. The aim of this study was to unravel whether TTR has a role in nerve physiology that could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e37270ecd9c8e89f4bc7e44410772fe9
https://pubmed.ncbi.nlm.nih.gov/17897357
https://pubmed.ncbi.nlm.nih.gov/17897357
Publikováno v:
The Journal of biological chemistry. 279(51)
Transthyretin (TTR) is a homotetrameric plasma protein that, in conditions not yet completely understood, may aggregate, forming the fibrillar material associated with TTR amyloidosis. A number of reported experiments indicate that dissociation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a6732d2511f64dd6b0b7dc412a40356
https://pubmed.ncbi.nlm.nih.gov/15469931
https://pubmed.ncbi.nlm.nih.gov/15469931