Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

Autor: Pablo Fernández-Tussy, Rubén Rodríguez-Agudo, David Fernández-Ramos, Lucía Barbier-Torres, Imanol Zubiete-Franco, Sergio López de Davalillo, Elisa Herraez, Naroa Goikoetxea-Usandizaga, Sofia Lachiondo-Ortega, Jorge Simón, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de Juan, Misti V. McCain, Maria J. Perugorria, Jon Mabe, Nicolás Navasa, Cecilia M. P. Rodrigues, Isabel Fabregat, Loreto Boix, Victor Sapena, Juan Anguita, Shelly C. Lu, José M. Mato, Jesus M. Banales, Erica Villa, Helen L. Reeves, Jordi Bruix, Maria Reig, Jose J. G. Marin, Teresa C. Delgado, María L. Martínez-Chantar

Publikováno v: Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)

Abstract Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma (HCC), although the

Externí odkaz: https://doaj.org/article/fb7ef154614446039d3b36ccb14472c8

Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

Autor: Paula Olaizola, Pui Yuen Lee-Law, Maite G. Fernandez-Barrena, Laura Alvarez, Massimiliano Cadamuro, Mikel Azkargorta, Colm J. O’Rourke, Francisco J. Caballero-Camino, Irene Olaizola, Rocio I.R. Macias, Jose J.G. Marin, Marina Serrano-Maciá, Maria L. Martinez-Chantar, Matias A. Avila, Patricia Aspichueta, Diego F. Calvisi, Matthias Evert, Luca Fabris, Rui E. Castro, Felix Elortza, Jesper B. Andersen, Luis Bujanda, Pedro M. Rodrigues, Maria J. Perugorria, Jesus M. Banales

Publikováno v: Olaizola, P, Lee-Law, P Y, Fernandez-Barrena, M G, Alvarez, L, Cadamuro, M, Azkargorta, M, O'Rourke, C J, Caballero-Camino, F J, Olaizola, I, Macias, R I R, Marin, J J G, Serrano-Maciá, M, Martinez-Chantar, M L, Avila, M A, Aspichueta, P, Calvisi, D F, Evert, M, Fabris, L, Castro, R E, Elortza, F, Andersen, J B, Bujanda, L, Rodrigues, P M, Perugorria, M J & Banales, J M 2022, ' Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models ', Journal of Hepatology, vol. 77, no. 1, pp. 177-190 . https://doi.org/10.1016/j.jhep.2022.02.007
Addi. Archivo Digital para la Docencia y la Investigación
instname

[EN] BACKGROUND & AIMS: Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications (PTMs), including NEDDylation, result in abnormal protein dynamics,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc951961d3c4bc25aa43db66243e451
https://doi.org/10.1016/j.jhep.2022.02.007

Supplementary Table 2 from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

Autor: Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero

Supplementary table 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12aecb548819ccf19cdae6b1b63087f5
https://doi.org/10.1158/0008-5472.22430241.v1

Supplementary Table 1 from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

Autor: Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero

Supplementary Table 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddf213946fc87fd4f283ab64b4cde07
https://doi.org/10.1158/0008-5472.22430244

Supplementary Information from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

Autor: Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero

1-Supplementary methods 2-Supplementary Figure legends 3-Supplementary references

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c113bd0a2cdcb35d220f3dc823b4840
https://doi.org/10.1158/0008-5472.22430247.v1