Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria Isabel Trejo Zambrano"'
Autor:
Eduardo Gomez-Bañuelos, Yikai Yu, Jessica Li, Kevin S. Cashman, Merlin Paz, Maria Isabel Trejo-Zambrano, Regina Bugrovsky, Youliang Wang, Asiya Seema Chida, Cheryl A. Sherman-Baust, Dylan P. Ferris, Daniel W. Goldman, Erika Darrah, Michelle Petri, Iñaki Sanz, Felipe Andrade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
Externí odkaz:
https://doaj.org/article/0f1da98ab1e94d54a8c743920c6857c6
Publikováno v:
Antioxid Redox Signal
Significance: The production of antibodies to posttranslationally modified antigens is a hallmark in rheumatoid arthritis (RA). In particular, the presence of citrullination-associated antibodies, targeting both citrullinating enzymes (the peptidylar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96efe772ce0a8e78706f32ef4d6eaa5c
https://europepmc.org/articles/PMC8982126/
https://europepmc.org/articles/PMC8982126/
Autor:
Sherman-Baust C, Jessica Li, Maria Isabel Trejo-Zambrano, Felipe Andrade, Eduardo Gómez-Bañuelos, Erika Darrah, Merlin Paz, Iñaki Sanz, Daniel W. Goldman, Chida As, Ferris Dp, Regina Bugrovsky, Yuan Yu, Michelle Petri, Kevin S. Cashman, Yun F. Wang
DNase1L3 deficiency is an inborn error of immunity that causes monogenic systemic lupus erythematosus (SLE) in humans. Here, we identified that one third of patients with sporadic SLE have antibodies to DNase1L3. Like DNase1L3 deficiency, we found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2d8cda6073a4361df65ae010493693
https://doi.org/10.1101/2021.06.07.21258180
https://doi.org/10.1101/2021.06.07.21258180
Autor:
David R. Thiemann, Andrea L. Cox, Katherine J. Fenstermacher, Richard E. Rothman, Carolyn E. Machamer, Scott L. Zeger, Jody E. Hooper, Elissa K. Leonard, Zitong Wang, William Clarke, Lisa Christopher-Stine, David Hines, Andrew Pekosz, Brian T. Garibaldi, Maria Isabel Trejo Zambrano, Jamie B. Spangler, Livia Casciola-Rosen, Oliver Laeyendecker, Lauren M. Sauer, Christopher A. Mecoli, Stuart C. Ray, Antony Rosen, Qingyuan Yang, Felipe Andrade, Laura Gutierrez-Alamillo
Publikováno v:
medRxiv : the preprint server for health sciences.
SARS-CoV-2 infection induces severe disease in a subpopulation of patients, but the underlying mechanisms remain unclear. We demonstrate robust IgM autoantibodies that recognize angiotensin converting enzyme-2 (ACE2) in 18/66 (27%) patients with seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08755168cd9c39860bc079f3a38ebf15
https://pubmed.ncbi.nlm.nih.gov/35349483
https://pubmed.ncbi.nlm.nih.gov/35349483
Autor:
Eduardo Gómez-Bañuelos, Felipe Andrade, Brendan Antiochos, Livia Casciola-Rosen, Antony Rosen, Maria Isabel Trejo-Zambrano, Eric J. Gapud, Eleni Tiniakou, David J. Granville
Publikováno v:
J Immunol
Granzyme B (GrB) is an immune protease implicated in the pathogenesis of several human diseases. In the current model of GrB activity, perforin determines whether the downstream actions of GrB occur intracellularly or extracellularly, producing apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd5e1465cfd8221546792358c2da7df
https://pubmed.ncbi.nlm.nih.gov/33288544
https://pubmed.ncbi.nlm.nih.gov/33288544