Výsledky vyhledávání - "Maria Isabel Cerezo-Guisado"

p38 MAPK Down-regulates Fibulin 3 Expression through Methylation of Gene Regulatory Sequences

Autor: C. Roncero, Ana Vázquez-Carballo, Sara Ortiz-Rivero, Carmen Guerrero, Neibla Priego, Alvaro Gutierrez-Uzquiza, María Arechederra, Maria Isabel Cerezo-Guisado, Ana Cuenda, Celia Sequera, Almudena Porras

Publikováno v: Journal of Biological Chemistry. 290:4383-4397

p38 MAPKs regulate migration and invasion. However, the mechanisms involved are only partially known. We had previously identified fibulin 3, which plays a role in migration, invasion, and tumorigenesis, as a gene regulated by p38α. We have characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7563d575090b6d903ab623be10a12490
https://doi.org/10.1074/jbc.m114.582239

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p38γ regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

Autor: Paloma del Reino, J. Simon C. Arthur, Maria Isabel Cerezo-Guisado, Ana Cuenda, Francisco Centeno, Francisco Inesta-Vaquera, Guadalupe Sabio, David G. Campbell, Simon Rousseau

Publikováno v: Journal of Cell Science. 123:2596-2604

Activation of p38γ modulates the integrity of the complex formed by the human discs large protein (hDlg) with cytoskeletal proteins, which is important for cell adaptation to changes in environmental osmolarity. Here we report that, in response to h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b187877bc83bf3708401ef226e77c2
https://doi.org/10.1242/jcs.066514

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Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG

Autor: M. J. Lorenzo, Ana Risco, Ana Cuenda, Alberto Álvarez-Barrientos, Francisco Centeno, Miguel A. Martín-Serrano, Rafal Zur, Maria Isabel Cerezo-Guisado

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 84

We investigated apoptosis induced by the green tea component the epigallocatechin-3-gallate (EGCG) and the pathways underlying its activity in a colon cancer cell line. A complete understanding of the mechanism(s) and molecules targeted by green tea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af0fb37d452ce33cdf15481f05a6c92
https://pubmed.ncbi.nlm.nih.gov/26303273

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Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

Autor: Francisco Javier Oliver, Pedro M. Fernández-Salguero, Jaime M. Merino, Javier Sáenz-Santamaría, Alberto Álvarez-Barrientos, Inmaculada Catalina-Fernández, Maria Isabel Cerezo-Guisado, Eva Barrasa, Antonio Morales-Hernández, María Isabel Rodríguez, Javier Rey-Barroso, María Contador-Troca

Publikováno v: Molecular Cancer
Molecular Cancer, 2015, 14 (1), pp.148. ⟨10.1186/s12943-015-0419-9⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

[Background] The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3fdd72207723bde6dace7c48228a76
https://doi.org/10.1186/s12943-015-0419-9

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Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts

Autor: Luis J. Garcia-Marin, Maria Isabel Cerezo-Guisado, Lauro González-Fernández, M. J. Lorenzo, Maria J. Bragado, Sonja Langmesser

Publikováno v: FEBS Journal. 273:1-13

We have previously shown that lovastatin induces apoptosis in spontaneously immortalized rat brain neuroblasts. Focal adhesion proteins and protein kinase Cdelta (PKCdelta) have been implicated in the regulation of apoptosis. We found that lovastatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ca20267097935d4fe3b8ccb255088
https://doi.org/10.1111/j.1742-4658.2005.05023.x

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CCK1 and 2 receptors are expressed in immortalized rat brain neuroblasts: intracellular signals after cholecystokinin stimulation

Autor: Luis J. Garcia-Marin, Maria Isabel Cerezo-Guisado, Maria J. Bragado, Sonja Langmesser, M. J. Lorenzo

Publikováno v: Journal of cellular biochemistry. 100(4)

Cholecystokinin (CCK) is one of the most abundant neuropeptides in the central nervous system (CNS) where it promotes important functions by activation of receptors CCK1 and CCK2. Our aim was to investigate CCK receptors expression and their downstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3981345841e53b14b081b15bcb77048a
https://pubmed.ncbi.nlm.nih.gov/17226751

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Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts

Autor: Maria J. Bragado, M. J. Lorenzo, Natalia Garcı́a-Román, Alberto Álvarez-Barrientos, Luis J. Garcia-Marin, Maria Isabel Cerezo-Guisado

Publikováno v: The Biochemical journal. 401(1)

We have shown previously that lovastatin, a 3-hydroxy-3-methyl- glutaryl coenzyme A reductase inhibitor, induces apoptosis in spontaneously immortalized rat brain neuroblasts. In the present study, we analysed the intracellular signal transduction pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f47bea5bc954417133e3b2ffde4c3c
https://pubmed.ncbi.nlm.nih.gov/16952276

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c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis

Autor: Ricardo Argent, Maria J. Bragado, Luis J. Garcia-Marin, Maria Isabel Cerezo-Guisado, Alberto Álvarez-Barrientos, M. J. Lorenzo

Publikováno v: Biochimica et biophysica acta. 1771(2)

We have previously shown that lovastatin, an HMG-CoA reductase inhibitor, induces apoptosis in rat brain neuroblasts. c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) are implicated in regulation of neuronal apoptosis. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47676b943120ee7f0b9d8ed6969d3ed0
https://pubmed.ncbi.nlm.nih.gov/17251057

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Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts

Autor: Maria J. Bragado, M. J. Lorenzo, Luis J. Garcia-Marin, Maria Isabel Cerezo-Guisado

Publikováno v: Journal of neurochemistry. 94(5)

We previously showed that lovastatin, an HMG-CoA reductase inhibitor, suppresses cell growth by inducing apoptosis in rat brain neuroblasts. Our aim was to study intracellular signalling induced by lovastatin in neuroblasts. Lovastatin significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6f47bf73a359bf0285bc62d9db690b
https://pubmed.ncbi.nlm.nih.gov/16111478

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