Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Maria Irene Pires Pacheco"'
Publikováno v:
Biochemical Society Transactions
Currently, the development of new effective drugs for cancer therapy is not only hindered by development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug resistance in cancer. Hence, new tools are needed to study the und
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103331-(2021)
iScience, Vol 24, Iss 11, Pp 103331-(2021)
The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks. Here, FBA was applied on human lung cells infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7384a533214aca4f7596bde2047d22
http://arxiv.org/abs/2103.13844
http://arxiv.org/abs/2103.13844
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-16 (2021)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Metabolic modeling enables the study of human metabolism in healthy and in diseased conditions, e.g., the prediction of new drug targets and biomarkers for metabolic diseases. To accurately describe blood and urine metabolite dynamics, the integratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d44e57252790eead785a3614bcf21d7
http://orbilu.uni.lu/handle/10993/46061
http://orbilu.uni.lu/handle/10993/46061
Autor:
Marco Carretta, Marco Donia, Daniel H. Madsen, Shawez Khan, Daniela De Zio, Caroline Robert, Jose Javier Bravo-Cordero, Giuseppe Filomeni, Colin J. Daniel, Maria Irene Pires Pacheco, Luca Di Leo, Valérie Bodemeyer, Thomas Sauter, Giuseppina Claps, Francesco Cecconi, Per Guldberg, Fiorella Faienza, Rosalie C. Sears, Julie Di Martino, Salvatore Rizza, Matteo Bordi, Francesca Maria Bosisio, Alex Frias
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Di Leo, L, Bodemeyer, V, Bosisio, F M, Claps, G, Carretta, M, Rizza, S, Faienza, F, Frias, A, Khan, S, Bordi, M, Pacheco, M P, Di Martino, J, Bravo-Cordero, J J, Daniel, C J, Sears, R C, Donia, M, Madsen, D H, Guldberg, P, Filomeni, G, Sauter, T, Robert, C, De Zio, D & Cecconi, F 2021, ' Loss of Ambra1 promotes melanoma growth and invasion ', Nature Communications, vol. 12, 2550 . https://doi.org/10.1038/s41467-021-22772-2
Autophagy
Di Leo, L, Bodemeyer, V, Bosisio, F M, Claps, G, Carretta, M, Rizza, S, Faienza, F, Frias, A, Khan, S, Bordi, M, Pacheco, M P, Di Martino, J, Bravo-Cordero, J J, Daniel, C J, Sears, R C, Donia, M, Madsen, D H, Guldberg, P, Filomeni, G, Sauter, T, Robert, C, De Zio, D & Cecconi, F 2021, ' Loss of Ambra1 promotes melanoma growth and invasion ', Nature Communications, vol. 12, no. 1, 2550, pp. 2550 . https://doi.org/10.1038/s41467-021-22772-2
Di Leo, L, Bodemeyer, V, Bosisio, F M, Claps, G, Carretta, M, Rizza, S, Faienza, F, Frias, A, Khan, S, Bordi, M, Pacheco, M P, Di Martino, J, Bravo-Cordero, J J, Daniel, C J, Sears, R C, Donia, M, Madsen, D H, Guldberg, P, Filomeni, G, Sauter, T, Robert, C, De Zio, D & Cecconi, F 2021, ' Loss of Ambra1 promotes melanoma growth and invasion ', Nature Communications, vol. 12, 2550 . https://doi.org/10.1038/s41467-021-22772-2
Autophagy
Di Leo, L, Bodemeyer, V, Bosisio, F M, Claps, G, Carretta, M, Rizza, S, Faienza, F, Frias, A, Khan, S, Bordi, M, Pacheco, M P, Di Martino, J, Bravo-Cordero, J J, Daniel, C J, Sears, R C, Donia, M, Madsen, D H, Guldberg, P, Filomeni, G, Sauter, T, Robert, C, De Zio, D & Cecconi, F 2021, ' Loss of Ambra1 promotes melanoma growth and invasion ', Nature Communications, vol. 12, no. 1, 2550, pp. 2550 . https://doi.org/10.1038/s41467-021-22772-2
Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the molecular mechanisms underlying melanoma biology and in defining new curative strategies, the therapeutic needs for this disease have not yet been fulfilled. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c573012ecdeefa0c085f95b995c5a747
http://orbilu.uni.lu/handle/10993/47062
http://orbilu.uni.lu/handle/10993/47062
The interpretation of the number of COVID-19 cases and deaths in a country or region is strongly dependent on the number of performed tests. We developed a novel SIR based epidemiological model (SIVRT) which allows the country-specific integration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03426d45451c946be9f0807d3ba564c5
http://orbilu.uni.lu/handle/10993/43970
http://orbilu.uni.lu/handle/10993/43970
Autor:
Elisabeth Letellier, Dagmar Kulms, Thomas Sauter, Tamara Jean Rita Bintener, Serge Haan, Dominik Ternes, Maria Irene Pires Pacheco
Publikováno v:
EBioMedicine, 43(May 2019), 98-106. Amsterdam, Netherlands: Elsevier (2019).
Background Metabolic rewiring allows cancer cells to sustain high proliferation rates. Thus, targeting only the cancer-specific cellular metabolism will safeguard healthy tissues. Methods We developed the very efficient FASTCORMICS RNA-seq workflow (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb4ea7ccd6791d2450f0a2ccee39c2c
http://orbilu.uni.lu/handle/10993/39999
http://orbilu.uni.lu/handle/10993/39999
Publikováno v:
Computational Biology ISBN: 9783030172961
Automated Reasoning for Systems Biology and Medicine
Automated Reasoning for Systems Biology and Medicine
The decreasing cost of high-throughput technologies allows to consider their use in healthcare and medicine. To prepare for this upcoming revolution, the community is assembling large disease-dedicated datasets such as TCGA or METABRIC. These dataset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c532a70c07e7346b0371717141afddc
https://doi.org/10.1007/978-3-030-17297-8_15
https://doi.org/10.1007/978-3-030-17297-8_15
Autor:
Joëlle V. Fritz, Almut Heinken, Joanna Baginska, Ines Thiele, Thomas Sauter, Kacy Greenhalgh, Maria Irene Pires Pacheco, Pit Ullmann, Pranjul Shah, Paul Wilmes, Elisabeth Letellier, Tamara Jean Rita Bintener, Rashi Halder, Serge Haan, Audrey Frachet, Javier Ramiro-Garcia
Publikováno v:
Cell Reports
Cell Reports, Vol 27, Iss 5, Pp 1621-1632.e9 (2019)
Cell Reports, Vol 27, Iss 5, Pp 1621-1632.e9 (2019)
By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented determining the potential combina
Autor:
Mate Rusz, Dominik Egger, Gunda Koellensperger, Giada Marino, Cornelia Kasper, Evelyn Rampler, Maria Irene Pires Pacheco, Thomas Naegele, Harald Schoeny
Publikováno v:
Molecules, Vol 24, Iss 19, p 3615 (2019)
Molecules
Volume 24
Issue 19
Molecules
Volume 24
Issue 19
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocyt
Autor:
Maria Irene Pires Pacheco, Audrey Frachet, Tamara Jean Rita Bintener, Joëlle V. Fritz, Serge Haan, Pranjul Shah, Thomas Sauter, Elisabeth Letellier, Javier Ramiro-Garcia, Kacy Greenhalgh, Rashi Halder, Pit Ullmann, Paul Wilmes, Joanna Baginska, Almut Heinken, Ines Thiele
Publikováno v:
SSRN Electronic Journal.
By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented determining the potential combina