Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria Ieva"'
Autor:
Andrew Novak, David Laughton, Rebecca Lane, Emma Blackham, Jennifer Thomas, Elli Chatzopoulou, Joseph Wrigglesworth, Abdul Quddus, Saleh Ahmed, David Cousin, Lorna Duffy, Nathalie Dubois, John Unitt, Katalin Orban, Edward Browne, Michelle Ward, David Mycock, Maria Ieva, Nicholas Bland, Pascal George, Timothy Bourne, Hélène Asnagli, Louise Birch, Geraint Jones
Publikováno v:
Journal of Medicinal Chemistry. 65:16640-16650
Herein, we report the discovery of a first-in-class chemotype 2-(alkylsulfonamido)thiazol-4-yl)acetamides that act as pan-selective inhibitors of cytidine 5'-triphosphate synthetase (CTPS1/2), critical enzymes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ef9951f3a13e9255109c54a35d4764
https://doi.org/10.1021/acs.jmedchem.2c01446
https://doi.org/10.1021/acs.jmedchem.2c01446
Autor:
Lilian McNab, Andrew Wright, Scott Borthwick, Maria Ieva, Emma J. Rozgowska, Hamish McNab, Jonathan S. Foot
Publikováno v:
Arkivoc. 2020:161-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd293cc9b75c60280059824556d50e9a
https://doi.org/10.24820/ark.5550190.p011.257
https://doi.org/10.24820/ark.5550190.p011.257
Autor:
Hamish McNab, Simon Parsons, Alistair R. Lennie, Elna Pidcock, John E. Warren, Russell D. L. Johnstone, Maria Ieva
Publikováno v:
CrystEngComm. 12:2520
Methyl 2-(carbazol-9-yl)benzoate is unusual in crystallising with eight molecules in the crystallographic asymmetric unit (Z′ = 8). Under high pressure it transforms to a Z′ = 2 structure. The molecules in the Z′ = 2 phase have unfavourable con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245214bfbc999e94508bea921f9e4139
https://doi.org/10.1039/b917290d
https://doi.org/10.1039/b917290d
Publikováno v:
Dalton Transactions. 39:7147
X-Ray crystal structures, and calculated structures (at B3LYP/6-31G level) are reported for seven N-arylbenzazoles (two carbazoles, indoles and benzimidazoles, and one indazole) bearing electron withdrawing groups in the 2-position of the N-aryl ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a3ea537782dd7774eb694e2f47c0e
https://doi.org/10.1039/c0dt00029a
https://doi.org/10.1039/c0dt00029a
Autor:
Russell D. L. Johnstone, Maria Ieva, Alistair R. Lennie, Hamish McNab, Elna Pidcock, John E. Warren, Simon Parsons
Publikováno v:
CrystEngComm; Sep2010, Vol. 12 Issue 9, p2520-2523, 4p