Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria I. Lazaro-Pena"'
HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Autor:
Maria I. Lazaro-Pena, Zachary C. Ward, Sifan Yang, Alexandra Strohm, Alyssa K. Merrill, Celia A. Soto, Andrew V. Samuelson
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Discoveries made in the nematode Caenorhabditis elegans revealed that aging is under genetic control. Since these transformative initial studies, C. elegans has become a premier model system for aging research. Critically, the genes, pathways, and pr
Externí odkaz:
https://doaj.org/article/3518703fb6c7441ca904dcc0299d11cc
Autor:
Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson
Publikováno v:
eLife, Vol 12 (2023)
Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an
Externí odkaz:
https://doaj.org/article/c298475de3254457ae6029f66836d12b
Autor:
Maria I. Lazaro-Pena, Adam B. Cornwell, Carlos A. Diaz-Balzac, Ritika Das, Nicholas Macoretta, Juilee Thakar, Andrew V. Samuelson
Publikováno v:
bioRxiv
Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfaf4d238e8e20fe6cde6736ae821a4
https://doi.org/10.1101/2023.01.11.523661
https://doi.org/10.1101/2023.01.11.523661
The nervous system systemically coordinates proteostasis to delay organismal aging. However, the neuronal regulatory mechanisms that coordinate cellular anti-aging programs across tissue and cell-types are relatively unknown. In this work, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c6760136ba421fa21e65bb792c64c8
https://doi.org/10.1101/2022.04.02.486836
https://doi.org/10.1101/2022.04.02.486836
Publikováno v:
Journal of Visualized Experiments.
The ability to maintain proper function and folding of the proteome (protein homeostasis) declines during normal aging, facilitating the onset of a growing number of age-associated diseases. For instance, proteins with polyglutamine expansions are pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ebf120f9446e9f110abf1054cb1fc2
https://doi.org/10.3791/61100-v
https://doi.org/10.3791/61100-v
Publikováno v:
Results and Problems in Cell Differentiation ISBN: 9783319924854
Echinoderms possess an incredible regenerative capacity. Within this phylum, holothurians, better known as sea cucumbers, can regenerate most of their internal and external organs. While regeneration has been studied in several species, the most rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61ddc6e362c56b3d46be76a056c7a05e
https://doi.org/10.1007/978-3-319-92486-1_13
https://doi.org/10.1007/978-3-319-92486-1_13
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1377-1384 (2015)
Neurite branching is essential for correct assembly of neural circuits, yet it remains a poorly understood process. For example, the neural cell adhesion molecule KAL-1/anosmin-1, which is mutated in Kallmann syndrome, regulates neurite branching thr
Externí odkaz:
https://doaj.org/article/0de38c314fd44f91b96c3aa0751cde83