Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Maria I. Kontaridis"'
Autor:
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of
Externí odkaz:
https://doaj.org/article/8786074726574cf993ac21c17b758fad
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Protein Tyrosine Phosphatase 1B (PTP1B) has emerged as a significant regulator of metabolic and cardiovascular disease. It is a non-transmembrane protein tyrosine phosphatase that negatively regulates multiple signaling pathways integral to the regul
Externí odkaz:
https://doaj.org/article/6488faaef51e4ae78ef5e8a7180eed7d
Autor:
Tackla Winston, Yuanhui Song, Huaiyu Shi, Junhui Yang, Munther Alsudais, Maria I. Kontaridis, Yaoying Wu, Thomas R. Gaborski, Qinghe Meng, Robert N. Cooney, Zhen Ma
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Over the past decades, mesenchymal stromal cells (MSCs) have been extensively investigated as a potential therapeutic cell source for the treatment of various disorders. Differentiation of MSCs from human induced pluripotent stem cells (iMSC
Externí odkaz:
https://doaj.org/article/c3c1a98291a240ac8fb96bf60b6ff868
Autor:
Guoping Li, Aidan C. Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P. Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D. Laurent, Sary F. Aranki, Maria I. Kontaridis, Louise C. Laurent, Kendall Van Keuren‐Jensen, Jochen Muehlschlegel, Todd M. Lowe, Saumya Das
Publikováno v:
Advanced Science, Vol 9, Iss 17, Pp n/a-n/a (2022)
Abstract The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may identify novel biomarkers and key signaling pathways for different diseases. Emerging
Externí odkaz:
https://doaj.org/article/1c604b8983c147c197c8d6c4daa9b57a
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
RASopathies are a family of rare autosomal dominant disorders that affect the canonical Ras/MAPK signaling pathway and manifest as neurodevelopmental systemic syndromes, including Costello syndrome (CS). In this issue of the JCI, Dard et al. describe
Externí odkaz:
https://doaj.org/article/8a601a6dcec9437f8362a78ace2176fc
Autor:
Rong Li, Amanda Baskfield, Yongshun Lin, Jeanette Beers, Jizhong Zou, Chengyu Liu, Fabrice Jaffré, Amy E. Roberts, Elizabeth A. Ottinger, Maria I. Kontaridis, Wei Zheng
Publikováno v:
Stem Cell Research, Vol 34, Iss , Pp - (2019)
Noonan syndrome with multiple lentigines (NSML), formerly known as LEOPARD Syndrome, is a rare autosomal dominant disorder. Approximately 90% of NSML cases are caused by missense mutations in the PTPN11 gene which encodes the protein tyrosine phospha
Externí odkaz:
https://doaj.org/article/85e415c868de4dcb8df0d931ee88ce89
Autor:
Yan Sun, Vasanth Chanrasekhar, Chase W. Kessinger, Peiyang Tang, Yunan Gao, Sarah Kamli-Salino, Katherine Nelson, Mirela Delibegovic, E. Dale Abel, Maria I. Kontaridis
BackgroundHeart failure is the number one cause of death worldwide and mortality is directly correlated with the high incidence of obesity and diabetes. Indeed, the epidemic phenomenon of obesity was projected to reach 50% in the US by the year 2030.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f1bfd8c90643232778ea99389db4c9
https://doi.org/10.1101/2023.05.19.541546
https://doi.org/10.1101/2023.05.19.541546
Autor:
Maria I. Kontaridis, Amy E. Roberts, Lisa Schill, Lisa Schoyer, Beth Stronach, Gregor Andelfinger, Yoko Aoki, Marni E. Axelrad, Annette Bakker, Anton M. Bennett, Alberto Broniscer, Pau Castel, Caitlin A. Chang, Lukas Cyganek, Tirtha K. Das, Jeroen Hertog, Emilia Galperin, Shruti Garg, Bruce D. Gelb, Kristiana Gordon, Tamar Green, Karen W. Gripp, Maxim Itkin, Maija Kiuru, Bruce R. Korf, Jeff R. Livingstone, Alejandro López‐Juárez, Pilar L. Magoulas, Sahar Mansour, Theresa Milner, Elisabeth Parker, Elizabeth I. Pierpont, Kevin Plouffe, Katherine A. Rauen, Suma P. Shankar, Shane B. Smith, David A. Stevenson, Marco Tartaglia, Richard Van, Morgan E. Wagner, Stephanie M. Ware, Martin Zenker
Publikováno v:
American journal of medical genetics. Part A, vol 188, iss 6
Kontaridis, M I, Roberts, A E, Schill, L, Schoyer, L, Stronach, B, Andelfinger, G, Aoki, Y, Axelrad, M E, Bakker, A, Bennett, A M, Broniscer, A, Castel, P, Chang, C A, Cyganek, L, Das, T K, den Hertog, J, Galperin, E, Garg, S, Gelb, B D, Gordon, K, Green, T, Gripp, K W, Itkin, M, Kiuru, M, Korf, B R, Livingstone, J R, López-Juárez, A, Magoulas, P L, Mansour, S, Milner, T, Parker, E, Pierpont, E I, Plouffe, K, Rauen, K A, Shankar, S P, Smith, S B, Stevenson, D A, Tartaglia, M, Van, R, Wagner, M E, Ware, S M & Zenker, M 2022, ' The seventh international RASopathies symposium : Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery ', American Journal of Medical Genetics. Part A . https://doi.org/10.1002/ajmg.a.62716
American Journal of Medical Genetics, Part A, 188(6), 1915-1927. Wiley-Liss Inc.
Kontaridis, M I, Roberts, A E, Schill, L, Schoyer, L, Stronach, B, Andelfinger, G, Aoki, Y, Axelrad, M E, Bakker, A, Bennett, A M, Broniscer, A, Castel, P, Chang, C A, Cyganek, L, Das, T K, den Hertog, J, Galperin, E, Garg, S, Gelb, B D, Gordon, K, Green, T, Gripp, K W, Itkin, M, Kiuru, M, Korf, B R, Livingstone, J R, López-Juárez, A, Magoulas, P L, Mansour, S, Milner, T, Parker, E, Pierpont, E I, Plouffe, K, Rauen, K A, Shankar, S P, Smith, S B, Stevenson, D A, Tartaglia, M, Van, R, Wagner, M E, Ware, S M & Zenker, M 2022, ' The seventh international RASopathies symposium : Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery ', American Journal of Medical Genetics. Part A . https://doi.org/10.1002/ajmg.a.62716
American Journal of Medical Genetics, Part A, 188(6), 1915-1927. Wiley-Liss Inc.
RASopathies are a group of genetic disorders that are caused by genes that affect the canonical Ras/mitogen-activated protein kinase (MAPK) signaling pathway. Despite tremendous progress in understanding the molecular consequences of these genetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66770a599b697c0d77d007bd425f8e74
https://escholarship.org/uc/item/44s997fh
https://escholarship.org/uc/item/44s997fh
Autor:
Plansky Hoang, Adriana M. Archilla, A. Gulhan Ercan-Sencicek, Andrew Kowalczewski, Wenzhong Liu, Jeffrey D. Amack, Zhen Ma, Tackla S. Winston, Abha R. Gupta, Maria I. Kontaridis, Shiyang Sun, Stephanie M. Lemus
Publikováno v:
Stem Cell Reports
Summary Emerging technologies in stem cell engineering have produced sophisticated organoid platforms by controlling stem cell fate via biomaterial instructive cues. By micropatterning and differentiating human induced pluripotent stem cells (hiPSCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a702c3c2ff822addec04354cc247ef
https://doi.org/10.1016/j.stemcr.2021.03.013
https://doi.org/10.1016/j.stemcr.2021.03.013
Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells
Autor:
Caroline Sheldon, Chase W. Kessinger, Yan Sun, Maria I. Kontaridis, Qianyi Ma, Saher Sue Hammoud, Zibei Gao, Hui Zhang, Zhiqiang Lin
Publikováno v:
Journal of molecular and cellular cardiology. 175
Myh6-Cre transgenic mouse line was known to express Cre recombinase only in the heart. Nevertheless, during breeding Myh6-Cre to Rosa26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcc8e563173699d6414b6b131eec38a
https://pubmed.ncbi.nlm.nih.gov/36584478
https://pubmed.ncbi.nlm.nih.gov/36584478