Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maria I. Kharitonova"'
Autor:
Alex Azhayev, Tuomo A. Keinänen, Mervi T. Hyvönen, Elena S. Matyugina, Anastasia L. Khandazhinskaya, Maria I. Kharitonova, Konstantinova Im, Vladimir Barai, Katherine L. Seley-Radtke, Sergey N. Kochetkov, Barbara Z. Eletskaya, Ilja V. Fateev, Alex R. Khomutov
Publikováno v:
Organicbiomolecular chemistry. 19(34)
Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing
Publikováno v:
Russian Chemical Reviews. 87:1111-1138
Autor:
Irina D. Konstantinova, Valery N. Charushin, I. V. Fateev, Galegov Ga, Anatoly I. Miroshnikov, Alexander S. Paramonov, Maria I. Kharitonova, Svetlana K. Kotovskaya, Alexei L. Kaushin, Valeria L. Аndronova, Мaria Ya. Berzina, Konstantin V. Аntonov
Publikováno v:
Synthesis. 49:1043-1052
1-(2′-Deoxy-2′-fluoro-β- d -arabinofuranosyl)benzimidazoles containing 4,6-difluoro-, 4,5,6-trifluoro-, 5-fluoro-6-methoxy-, and 5-methoxy-4,6-difluorobenzimidazole fragments were synthesized by using purine nucleoside phosphorylase-catalyzed ch
Autor:
Georgii A. Galegov, Alexei L. Kayushin, Svetlana K. Kotovskaya, Irina D. Konstantinova, Valery N. Charushin, Anatoly I. Miroshnikov, Ilja V. Fateev, Valeria L. Andronova, Maria I. Kharitonova
Publikováno v:
Synthesis. 48:394-406
A series of 5,6-disubstituted benzimidazole nucleosides, obtained earlier, did not show any significant antiviral activity at relatively low cytotoxicity in vitro. In the course of our research we have succeeded in introducing an additional fluorine
Autor:
Maria I. Kharitonova, Vasily N. Stepanenko, Anatoly I. Miroshnikov, Ilja V. Fateev, Konstantin V. Antonov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova, Yuri A. Sokolov, Frank Seela, Vladimir A. Stepchenko, Kartik Temburnikar, Katherine L. Seley-Radtke
Publikováno v:
Chemistry - A European Journal. 21:13401-13419
A wide range of natural purine analogues was used as probe to assess the mechanism of recognition by the wild-type (WT) E. coli purine nucleoside phosphorylase (PNP) versus its Ser90Ala mutant. The results were analyzed from viewpoint of the role of
Autor:
Maria I. Kharitonova, Svetlana K. Kotovskaya, Alexandra O. Denisova, Irina D. Konstantinova, Valeria L. Andronova, Alexei L. Kayushin, Valery N. Charushin, Anatoly I. Miroshnikov, Galegov Ga
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
Using the enzymatic transglycosylation reaction β-d-ribo- and 2'-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activit