Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maria I Giraldo"'
Autor:
Carlos A Rodríguez-Salazar, Sarah van Tol, Olivier Mailhot, Maria Gonzalez-Orozco, Gabriel T Galdino, Abbey N Warren, Natalia Teruel, Padmanava Behera, Kazi Sabrina Afreen, Lihong Zhang, Terry L Juelich, Jennifer K Smith, María Inés Zylber, Alexander N Freiberg, Rafael J Najmanovich, Maria I Giraldo, Ricardo Rajsbaum
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002544 (2024)
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We p
Externí odkaz:
https://doaj.org/article/99a4e0e8910746299e1402b8c51819c3
Autor:
Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010532 (2022)
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously s
Externí odkaz:
https://doaj.org/article/7f5b774b9b474e8c892f3effa42555aa
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Viruses, Vol 13, Iss 3, p 369 (2021)
Ubiquitination of proteins is a post-translational modification process with many different cellular functions, including protein stability, immune signaling, antiviral functions and virus replication. While ubiquitination of viral proteins can be us
Externí odkaz:
https://doaj.org/article/57e76e43589649a7b54df8425ddb9059
Publikováno v:
Annual review of pathology.
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to humans by mosquito vectors and represents an important health problem. Infections in pregnant women are of major concern because of potential devastating conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a2da6e80c367337bfdd9d7affba469
https://pubmed.ncbi.nlm.nih.gov/36151059
https://pubmed.ncbi.nlm.nih.gov/36151059
Autor:
Maria J Gonzalez Orozco, Adam Hage, Hongjie Xia, Matthew Huante, Sarah van Tol, Maria I Giraldo, Lucinda Puebla-Clark, Vineet Menachery, Robin Stephens, Mark Endsley, Janice Endsley, Pei-Yong Shi, Alexander Freiberg, Ricardo Rajsbaum
Publikováno v:
The Journal of Immunology. 208:51.07-51.07
Cytokines, such as type-I Interferons (IFN-I), are essential to mount an effective antiviral response. The production of IFN-I is regulated by multiple mechanisms, including ubiquitination of host signaling factors. However, viruses can hijack the ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0746796c616228410ca4e90e2bfd2a0b
https://doi.org/10.4049/jimmunol.208.supp.51.07
https://doi.org/10.4049/jimmunol.208.supp.51.07
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports. 38:110434
Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify factors regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fbf4c4605e03e84ed63f2ca9d216cd
https://doi.org/10.1016/j.celrep.2022.110434
https://doi.org/10.1016/j.celrep.2022.110434
Autor:
Leopoldo Aguilera-Aguirre, Maria I. Giraldo, Birte Kalveram, Adam Hage, Yuejin Liang, Alexander Niclas Freiberg, Ricardo Rajsbaum
Publikováno v:
The Journal of Immunology. 204:70.7-70.7
The innate immune response is essential to protect the host against virus infections. This response involves activation of signaling pathways leading to inflammatory and antiviral cytokines, which in excess can lead to tissue damage and disease. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287256637c9b767eda1567538c62bc5b
https://doi.org/10.4049/jimmunol.204.supp.70.7
https://doi.org/10.4049/jimmunol.204.supp.70.7
Publikováno v:
Viruses, Vol 16, Iss 8, p 1285 (2024)
The E3 ubiquitin ligase TRIM7 is known to have dual roles during viral infections. Like other TRIM proteins, TRIM7 can regulate the IFN pathway via the regulation of the cytosolic receptors RIG-I or MDA-5, which promote the production of type I inter
Externí odkaz:
https://doaj.org/article/f93c5ac8229e40719e21b5465d5eef90