Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

Autor: Maria I Fonseca, Shuhui Chu, Aimee L Pierce, William D Brubaker, Richard E Hauhart, Diego Mastroeni, Elizabeth V Clarke, Joseph Rogers, John P Atkinson, Andrea J Tenner

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149792 (2016)

Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b

Externí odkaz: https://doaj.org/article/e80b68870340438f96ecae3c7cc77d03

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression

Autor: Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)

Abstract Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, rec

Externí odkaz: https://doaj.org/article/d254ddd8a4eb41ccbf2722299212173b

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Autor: Lindsay A. Hohsfield, Michael X. Hernandez, Maria D. Torres, Melody J. Fang, Shan Jiang, Maria I. Fonseca, Shu Hui Chu, Kim N. Green, Ali Mortazavi, Rick A. Wetsel, Tracy A. Cole, Andrea J. Tenner

Publikováno v: Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Hernandez, MX; Jiang, S; Cole, TA; Chu, S-H; Fonseca, MI; Fang, MJ; et al.(2017). Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss. MOLECULAR NEURODEGENERATION, 12. doi: 10.1186/s13024-017-0210-z. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/72n4f4fj
Molecular Neurodegeneration

Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models. To validate that the effect of the antagonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67f225f5823f9478fad22aa13c9a086
http://link.springer.com/article/10.1186/s13024-017-0210-z

C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta

Autor: Michael X. Hernandez, Eric Nguyen, Andrea J. Tenner, Pouya Namiranian, Maria I. Fonseca

Publikováno v: ASN Neuro, Vol 9 (2017)
Hernandez, MX; Namiranian, P; Nguyen, E; Fonseca, MI; & Tenner, AJ. (2017). C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta. ASN NEURO, 9(1). doi: 10.1177/1759091416687871. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/98f9g8zw
ASN NEURO

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0091cece5071a311ccb5c496cacbaad
https://doaj.org/article/201ce889f16d4386ae31ad1225ecea53

Influence of C5aR1 signaling on microglial CR3 expression in an Alzheimer's disease mouse model

Autor: Andrea J. Tenner, Shu-Hui Chu, Rick A. Wetsel, Maria I. Fonseca

Publikováno v: Molecular Immunology. 102:219

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ff3ae5faf3090eb7a13a16e06fa97c4
https://doi.org/10.1016/j.molimm.2018.06.224