Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria Hubmann"'
Autor:
Krzysztof Chylinski, Maria Hubmann, Ruth E. Hanna, Connor Yanchus, Georg Michlits, Esther C. H. Uijttewaal, John Doench, Daniel Schramek, Ulrich Elling
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Inducible genome editing systems often suffer from leakiness or reduced activity. Here the authors develop CRISPR-Switch, a Cre recombinase ON/OFF-controlled sgRNA cassette that allows consecutive editing of two loci.
Externí odkaz:
https://doaj.org/article/e256e98fa6a7453b8ef036e4dd9081b9
Autor:
Matthias Hinterndorfer, Max Gijsbertsen, Gintautas Vainorius, Johannes Zuber, Ulrich Elling, Thomas R Burkard, Tobias Neumann, Julian Jude, Maria Hubmann, Michaela Fellner, Alexander Schleiffer, Anna K. Traunbauer, Melanie Talata De Almeida, Georg Michlits
Publikováno v:
Nature Methods. 17:708-716
CRISPR-Cas9 screens have emerged as a transformative approach to systematically probe gene functions. The quality and success of these screens depends on the frequencies of loss-of-function alleles, particularly in negative-selection screens widely a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5796a0c8ff28b9823408cfd369ddbea7
https://doi.org/10.1038/s41592-020-0850-8
https://doi.org/10.1038/s41592-020-0850-8
Autor:
Georg, Michlits, Julian, Jude, Matthias, Hinterndorfer, Melanie, de Almeida, Gintautas, Vainorius, Maria, Hubmann, Tobias, Neumann, Alexander, Schleiffer, Thomas Rainer, Burkard, Michaela, Fellner, Max, Gijsbertsen, Anna, Traunbauer, Johannes, Zuber, Ulrich, Elling
Publikováno v:
Nature methods. 17(7)
CRISPR-Cas9 screens have emerged as a transformative approach to systematically probe gene functions. The quality and success of these screens depends on the frequencies of loss-of-function alleles, particularly in negative-selection screens widely a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efe55b45f3c06d0c5e22dc18429d8dfe
https://pubmed.ncbi.nlm.nih.gov/32514112
https://pubmed.ncbi.nlm.nih.gov/32514112
Autor:
Maria Ninova, Marietta Zinner, Howard Y. Chang, Johannes Zuber, Simon E. Vidal, Geneviève Almouzni, Nadezhda Abazova, Max Hogue, Sihem Cheloufi, Youngsook L. Jung, Maria Hubmann, Daniel J. Wesche, Jernej Murn, Ulrich Elling, Daniel Wenzel, Francesco Ferrari, Konrad Hochedlinger, Justin Brumbaugh, Josef M. Penninger, Oliver Bell, Philipp Rathert, Barbara Hopfgartner, Nilgun Tasdemir, Andres Blanco, Yang Shi, Michaela Fellner, Alexei A. Aravin, Julian Jude, John L. Rinn, Marius Wernig, Aimee I. Badeaux, Peter J. Park, Cheen Euong Ang, Scott W. Lowe, Danielle Tenen, Matthias Stadtfeld
Publikováno v:
Nature, vol 528, iss 7581
Nature
Nature
Cellular differentiation involves profound remodelling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78b191697998bf1be96e6dac8accee7
https://resolver.caltech.edu/CaltechAUTHORS:20160105-101557021
https://resolver.caltech.edu/CaltechAUTHORS:20160105-101557021
Autor:
Petra Dorninger, Ferdinand Steinboeck, Erich Heidenreich, Theresia Lengheimer, Maria Hubmann, Alexandra Bogusch
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 688:47-52
Mutations arising during times of cell cycle-arrest may considerably contribute to aging and cancerogenesis. Endogenous oxidative stress could be one of the major triggers for these mutations. We used Saccharomyces cerevisiae cells, arrested by starv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfafa6d242ea8b1fd45b4d7414ae899
https://doi.org/10.1016/j.mrfmmm.2010.03.006
https://doi.org/10.1016/j.mrfmmm.2010.03.006